Zuclopenthixol

Description

Zuclopenthixol is used for the acute and long-term treatment of schizophrenia and mental illnesses with a disturbance in thinking, emotional reaction, and behavior. This medicine is not recommended for use in patients less than 18 years of age.

Side effects

Major & minor side effects for Zuclopenthixol

  • Difficulty in breathing
  • High fever
  • Excessive sweating
  • Fast heartbeat
  • Twitching and unusual movement of muscles
  • Yellowing of skin and eyes
  • Decrease in blood cell count
  • Drowsiness
  • Loss of coordination
  • Migraine like headaches
  • Gait disturbance
  • Trouble concentrating
  • Memory problems
  • Fainting
  • Blurred vision
  • Increase in blood glucose level
  • Breast enlargement in men
  • Decreased blood pressure
  • Abnormal liver function
  • Mild to moderate depression
  • Agitation and anxiety
  • Loss of interest or pleasure
  • Decreased sexual urge
  • Vaginal dryness and irritation

Uses of Zuclopenthixol

What is it prescribed for?

  • Schizophrenia
  • Psychoses
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within hours of oral administration and within 2-4 hours of intramuscular administration. However, the onset time is likely to vary based on the formulation. The depot injection shows its initial effect within 3 days of intramuscular administration.
  • Duration of effect
    The oral forms generally remain effective for 8 to 24 hours. The intramuscular injections are usually effective for 2 to 3 days while the depot injections are usually effective for 2 to 4 weeks.
  • Safe with alcohol?
    Consumption of alcohol is not recommended while receiving this medicine since it may increase the risk of dizziness, sedation, etc. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if you consume alcohol during treatment with this medicine.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before beginning treatment with this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to zuclopenthixol or any other inactive ingredients present in the formulation.

Pheochromocytoma

This medicine is not recommended for use in patients with pheochromocytoma (a rare cancer of the adrenal gland) due to the increased risk of worsening of the patient’s condition.

Circulatory collapse

This medicine is not recommended for use in patients with circulatory collapse due to the increased risk of worsening of the patient’s condition.

Brain damage

This medicine is not recommended for use in patients with brain damage due to the increased risk of worsening of the patient’s condition.

Diminished consciousness

This medicine is not recommended for use in patients with reduced or diminished consciousness that may be caused by various factors such as alcohol intoxication, opiate/barbiturate poisoning, etc. due to the increased risk of worsening of the patient’s condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before beginning treatment with this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.
General warnings

Other medicines

Zuclopenthixol may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Use in the elderly

This medicine should be used with caution and monitoring in elderly patients since the risk of serious or fatal adverse effects is significantly high. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Use in children

This medicine is not recommended for use in children below 18 years of age since the safety and efficacy of use are not clinically established.

Heart diseases

This medicine should be used with caution in patients with pre-existing heart conditions or patients who have had a heart attack in recent times. Frequent clinical monitoring of heart functions may be needed in such cases. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases.

Liver diseases

This medicine should be used with caution in patients with an impairment of normal liver function. Appropriate dose adjustments and frequent monitoring of liver function tests may be needed. Use is not recommended if the impairment is severe.

Kidney diseases

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Myasthenia Gravis

This medicine should be used with extreme caution in patients having a degenerative disorder called myasthenia gravis. Use of this medicine should be reconsidered if the symptoms worsen after consumption. An alternative treatment option may be necessary in some cases based on the clinical condition.

Low potassium and magnesium levels

This medicine should be used with caution in patients with low levels of magnesium and potassium in the body. Treatment with this medicine should preferably resume only after the deficiency is corrected.

Driving or Operating machinery

Use of this medicine may cause symptoms such as blurred vision, dizziness, drowsiness, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Oral form: Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one. Injection: Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Oral form: Seek emergency medical treatment or contact the doctor in case of an overdose. Injection: Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while receiving this medicine since it may increase the risk of dizziness, sedation, etc. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Amitriptyline

Hydrochlorothiazide

Formoterol

Levodopa

Phenobarbital

Hydralazine

Ticlopidine

Atenolol

Erythromycin

Digoxin

Amiodarone

Cisapride

Imipramine

Thioridazine

Metoclopramide

Quinidine

Chlorpromazine

Warfarin

Lithium

Piperaquine

Astemizole

Disease interactions

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Convulsions

This medicine should be used with caution in patients with a history of fits or convulsions or have any condition that might cause fits, e.g. head injury, alcohol withdrawal, etc. due to the increased risk of worsening of the patient’s condition. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Parkinson's disease

This medicine should be used with caution in patients with Parkinson’s disease due to the increased risk of severe adverse effects. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Glaucoma

This medicine should be used with caution in patients with narrow-angle glaucoma or patients having a family history of the disease. Report any incidences of blurred vision, pain, dryness of the eyes, etc. to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Diabetes

This medicine should be used with caution in patients with diabetes due to the increased risk of severe adverse effects. Regular monitoring of blood sugar levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Asthma/ COPD

This medicine should be used with caution in patients with asthma/COPD due to the increased risk of severe adverse effects. Report any unusual symptoms to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Oral form: Take this medicine with or without food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesired side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor. Injection: This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by correcting certain chemical imbalances in the brain by acting on nerve pathways in specific areas of the brain.
Legal Status

Approved

Unknown

Approved

Unknown

Classification

Category

Antipsychotics

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2018 [cited 4 September 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.6414.pdf

[Internet]. Lundbeck.com. 2018 [cited 4 September 2018]. Available from:

https://lundbeck.com/upload/au/files/pdf/Clopixol_CMI.pdf

Zuclopenthixol [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 4 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Zuclopenthixol#section=Top

Zuclopenthixol - DrugBank [Internet]. Drugbank.ca. 2018 [cited 4 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB01624

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Information on this page was last updated on 11 Jan 2019

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.