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Zolex-S Tablet
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Zolex-S Tablet

Manufactured byALTA PHARMACEUTICALS PVT LTD
ContainsAlprazolam (0.5 mg) + Sertraline (25 mg)
Description
Zolex-S Tablet is a combination medicine which may be used in the treatment of social anxiety disorder, panic disorders, like unexpected extreme fear and tension due to stress, etc. Do not stop taking this medicine suddenly as it may cause withdrawal symptoms like seizures, aggressive behavior, blurred vision, etc.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Zolex-S Tablet

  • Changes in pattern of Speech
  • Unsteadiness
  • Loss of coordination
  • Drowsiness
  • Blurred vision
  • Abdominal pain
  • Painful urination
  • Headache
  • Sleeplessnes
  • Irregular menstrual periods
  • Chest pain
  • Decreased interest in sexual intercourse
  • Abnormal ejaculation
  • Aggression or anger
  • Diarrhea
  • Heart burn

Uses of Zolex-S Tablet

What is it prescribed for?

  • Panic disorder
  • Posttraumatic Stress Disorder
  • Social Anxiety Disorder
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 1-2 hours of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 2 to 3 days.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of severe adverse effects such as respiratory depression and breathlessness. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
  • Is this a habit forming medicine?
    Habit forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to alprazolam, sertraline, other benzodiazepines, or any other inactive ingredients present in the formulation.

Monoamine oxidase inhibitors

This medicine is not recommended for use in patients taking monoamine oxidase inhibitors (MAOI) due to the increased risk of serious and life-threatening side effects. A time gap of at least 14 days should be maintained between stopping therapy with MAOIs and starting therapy with this medicine.

CYP3A4 inhibitors

This medicine is not recommended for use in patients who are concomitantly taking CYP3A4 inhibitors such as itraconazole, ketoconazole, etc due to the increased risk of worsening of the patient's condition.

Acute narrow-angle glaucoma

This medicine is not recommended for use in patients with acute narrow-angle glaucoma due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Drug Abuse

This medicine should be used with caution in patients with a known history of drug abuse. Chances of dependency are very high, especially if the intended use is for a long duration of time. Patients should be monitored closely for any changes in mood and behavior and any drug-seeking behavior; any such changes should be reported to the doctor immediately.

Suicidal tendencies

This medicine should be used with caution due to the increased risk of suicidal tendencies. Patients should be closely monitored for any change in mood or behavior. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Use in Elderly

This medicine should be used with extreme caution in individuals who are 60 years old and above due to the increased risk of sedation and muscle weakness.

Kidney/Liver Diseases

This medicine should be used with caution in patients with kidney/liver diseases due to the increased risk of adverse effects. Regular monitoring of the kidney/liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Respiratory depression

This medicine should be used with caution in patients especially at high doses due to increased risk of respiratory depression which may result in coma and death. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Weight loss

Significant weight loss is observed in the patients treated with this medicine. Frequent monitoring of body weight is necessary. Any changes in the body weight should be reported to the doctor.

Withdrawal symptoms

Abrupt discontinuation of this medicine may increase the risk of adverse effects, especially if you have been using a high dose for a long duration. A gradual dose reduction is recommended to avoid these reactions. Do not stop the use of this medicine without consulting your doctor.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of severe adverse effects such as respiratory depression and breathlessness. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
Interaction with Medicine

Ciprofloxacin

Clozapine

Ondansetron

Opioids

Antihypertensives

Cetirizine

Metoclopramide

Diclofenac

Disease interactions

Seizure disorders

This medicine should be used with extreme caution in patients with seizure disorders due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Depression

This medicine should be used with caution in patients with depression due to the increased risk of suicidal thoughts. Patients caretakers should be educated about these symptoms. Any changes in the behavior should be reported to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Consumption of grapefruit juice is not recommended while receiving this medicine due to the increased risk of adverse effects.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine with or without food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine before completion of the course/without consulting your doctor as it may cause withdrawal symptoms.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Alprazolam works by decreasing the uncontrolled, excitatory activity in the brain. Sertraline works by increasing the certain chemical substances in the brain such as serotonin which helps to maintain mental balance.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Benzodiazepines, Selective serotonin reuptake inhibitors

Schedule

Schedule H

DailyMed - alprazolam tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 23 February 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2238e083-08f2-0aa8-59b7-16b6d68dbd48

Alprazolam: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 23 February 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a684001.html

Alprazolam - DrugBank [Internet]. Drugbank.ca. 2017 [cited 27 June 2017]. Available from:

https://www.drugbank.ca/drugs/DB00404

Sertraline: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 10 April 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a697048.html

DailyMed - sertraline hydrochloride tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 10 April 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f9641190-9151-4f7e-89ff-1e7a818c30ee#LINK_0e306600-7ee1-4b8a-b4f9-5339975de4de
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Information on this page was last updated on 21 Jun 2019

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