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Zixflam Tablet
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Zixflam Tablet

Manufactured byJENBURKT PHARMACEUTICALS LTD
ContainsAceclofenac (100 mg) + Trypsin Chymotrypsin (50000 Armour Units (AU)) + Bromelain (90 mg) + Rutoside (100 mg)
Description
Zixflam Tablet is a combination medicine used to relieve pain and inflammation associated with rheumatoid arthritis, osteoarthritis, spondylopathy, tendonitis, and bursitis. It is also used for the treatment of edema and inflammation following surgery such as tooth extraction, cellulitis, abscess, sports injuries, sprains, etc.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Zixflam Tablet

  • Abdominal pain
  • Constipation
  • Diarrhea
  • Nausea and vomiting
  • Skin rash
  • Severe allergic reaction
  • Increased blood pressure

Uses of Zixflam Tablet

What is it prescribed for?

  • Mild to moderate pain
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, rashes, nausea, joint pain, fever, etc. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to aceclofenac, trypsin, bromelain, rutoside or any other inactive ingredients present along with the formulation.

Asthma

This medicine is not recommended for use in patients with a known history of NSAID-induced asthma due to the increased risk of worsening of the patient's condition.

Bleeding disorder

This medicine is not recommended for use in patients with any bleeding disorder due to increased risk of swelling and bleeding in the stomach, colon, and anus.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Gastro-intestinal toxicity

This medicine may cause damage to the stomach, intestines, liver, etc., especially on prolonged use. This risk is especially higher in patients with a history of gastrointestinal diseases. Report any symptoms such as chronic indigestion, blood in stool or vomit, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Heart surgery

This medicine should not be taken to relieve pain before, during, or after a coronary artery bypass graft surgery due to the increased risk of severe adverse reactions.

Kidney/Liver Disease

This medicine should be used with extreme caution in patients with kidney/liver impairment due to the increased risk of adverse effects. Regular monitoring of the kidney/liver function tests is necessary while receiving this medicine for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or operating machinery

Use of this medicine may cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Other medicines

This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, rashes, nausea, joint pain, fever, etc. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
Interaction with Medicine

Lithium

Digoxin

Corticosteroids

Antihypertensives

Disease interactions

Asthma

This medicine is not recommended for use in patients with NSAID sensitive asthma due to the increased risk of worsening of the patient's condition. An alternative treatment option should be considered under your doctor's supervision.

Gastro-Intestinal toxicity

This medicine may cause damage to the stomach, intestines, liver, etc., especially on prolonged use. Report any symptoms such as chronic indigestion, blood in stool or vomit, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Kidney disease

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as prescribed by your doctor. Do not take in larger amounts or for longer durations than prescribed. Report any unusual symptoms to the doctor immediately. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Aceclofenac works by inhibiting the chemical substances in the body that causes pain and swelling. Trypsin chymotrypsin and Bromelain are enzymes which accelerate the tissue recovery process in the affected area. Rutoside acts as an antioxidant and also helps in relieving inflammation.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Miscellaneous analgesics

Schedule

Schedule H

Aceclofenac - DrugBank [Internet]. Drugbank.ca. 2019 [cited 23 July 2019]. Available from:

https://www.drugbank.ca/drugs/DB06736

DailyMed - Clanza CR- aceclofenac tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 2 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8a023942-01e8-4849-aa3c-1a640ffc7fd3

Aceclofenac [Internet]. Pubchem.ncbi.nlm.nih.gov. 2019 [cited 23 July 2019]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Aceclofenac
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Information on this page was last updated on 23 Jul 2019

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.