Zivast Am (5/10 mg) Tablet

Manufactured byFdc Ltd.
ContainsAmlodipine (5 mg) + Atorvastatin (10 mg)
Description

Zivast Am (5/10 mg) Tablet is a combination medicine used for the treatment of patients with both high blood pressure and hyperlipidemia. Patients are advised to follow a strict exercise and diet regimen along with this medicine to get the best possible effect.

Substitutes

List of substitutes for Zivast Am (5/10 mg) Tablet

Side effects

Major & minor side effects for Zivast Am (5/10 mg) Tablet

  • Cough
  • Difficulty in swallowing
  • Diarrhea
  • Impaired liver function
  • Joint pain
  • Muscle pain
  • Runny Nose
  • Difficulty in breathing
  • Insomnia
  • Swelling of ankles or feet
  • Dizziness
  • Increased heartbeat
  • Redness of face, neck, arms and chest
  • Acid or sour stomach
  • Stomach pain
  • Anxiety

Uses of Zivast Am (5/10 mg) Tablet

What is it prescribed for?

  • Coexisting essential hypertension and hyperlipidemia
  • Angina pectoris
  • Prevention of cardiovascular diseases
Read More
Concerns

Commonly asked questions

  • Onset of action
    The antihypertensive effect of this medicine can be observed within 6 to 12 hours. The anti-hyperlipidemic effect of this medicine is cumulative and may take up to 3 to 5 days to show its results.
  • Duration of effect
    The antihypertensive effect of this medicine lasts for an average duration of 24 hours. The anti-hyperlipidemic effect of this medicine may last for an average duration of 3 to 4 days after onset of action.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Liver disease

This medicine is not recommended for use in patients with active liver diseases since it may worsen the patient's condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to atorvastatin, amlodipine, or any other calcium-channel blockers.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Cognitive impairment

This medicine may cause forgetfulness, memory loss, confusion, etc. in some patients. These side effects are reversible and usually disappear once the medicine is discontinued.

Altered blood sugar levels

This medicine may cause an alteration in the blood sugar levels. This risk is especially higher in patients with diabetes mellitus. Close monitoring of blood sugar levels may be necessary based on the clinical condition. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.

Muscle degradation and Rhabdomyolysis

This medicine may cause muscle breakdown and rhabdomyolysis in some patients, a condition which can be fatal. This may cause symptoms such as severe tiredness and weakness. This risk is especially higher in the elderly population and in patients with kidney diseases, hypothyroidism, and active muscle disorders. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Heavy alcohol consumption

This medicine may cause liver and kidney injuries in patients consuming alcohol very frequently and in large quantities. Hence, consumption of alcohol should be avoided during treatment with this medicine.

Liver impairment

This medicine may cause moderate to severe liver impairment in some patients. Close monitoring of liver function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Stroke

This medicine is not recommended for use in patients recovering from a stroke since it may worsen the patient's condition.

Aortic stenosis

This medicine should be used with extreme caution in patients suffering from aortic stenosis due to the increased risk of a very low blood pressure. Close monitoring of blood pressure is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Coronary artery diseases

This medicine should be used with extreme caution in patients suffering from coronary artery diseases since it may worsen the patient's condition. Close monitoring of heart function and vital signs is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Pediatric use

This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

Driving and operating machines

This medicine may cause dizziness or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Carbamazepine

Clarithromycin

Erythromycin

Itraconazole

Azithromycin

Corticosteroids

Atazanavir

Cyclosporine

Rifampicin

Disease interactions

Liver Disease

This medicine is not recommended for use in patients with active liver diseases. In patients with liver impairment, this medicine should be used with extreme caution due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Diabetes

This medicine should be used with caution in patients with diabetes due to the increased risk of altered glucose levels. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Cardiogenic shock

This medicine is not recommended for use in patients suffering from a cardiogenic shock since it may worsen the patient's condition.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with this medicine due to the increased risk of adverse effects such as dizziness, muscle pain, fever and chills, headache, swelling of hands and feet, vomiting, skin rash, etc.
Lab interactions
Information not available.
Take this medicine as advised by your doctor. It can be taken with or without food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Amlodipine relaxes the heart muscles and the blood vessels. Atorvastatin reduces the level of cholesterol in the blood. Their combination is thus helpful in treating both hyperlipidemia and high blood pressure.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antihyperlipidemic combinations, Miscellaneous antihypertensive combinations

Schedule

Schedule H

DailyMed - Amlodipine tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 7 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1cec7a02-b7a5-49e1-ab64-3a4dab4149d2

[Internet]. 2017 [cited 7 March 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/24889

Amlodipine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 7 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a692044.html

Atorvastatin | C33H35FN2O5 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 23 February 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/60823

[Internet]. 2017 [cited 23 February 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.2498.latest.pdf

[Internet]. Fda.gov. 2017 [cited 6 November 2017]. Available from:

https://www.fda.gov/ohrms/dockets/dockets/06p0224/06P-0224-EC2-Attach-1.pdf
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