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Zerodol Spas (100/80 mg) Tablet

Manufactured byIpca Laboratories Pvt. Ltd.
ContainsAceclofenac (100 mg) + Drotaverine (80 mg)
Description
Zerodol Spas (100/80 mg) Tablet is a combination medicine that consists of Aceclofenac and Drotaverine. It is mainly used in the treatment of muscular pain associated with spasms in adults. It can also be used to treat dysmenorrhoea (pain associated with period cramps). Zerodol Spas (100/80 mg) Tablet can provide relief from pain and swelling that occurs due to muscle cramps and spasms. Zerodol Spas (100/80 mg) Tablet works by blocking certain enzyme receptors that cause muscle spasms and preventing the release of substances called prostaglandins in the brain that cause pain and fever. It can provide relief from pain and swelling due to arthritic conditions but does not cure it. Zerodol Spas (100/80 mg) Tablet may cause some side effects like dry mouth, nausea, vomiting, heartburn, stomach pain, loss of appetite, and diarrhoea. Do not use this medicine if you are allergic to it. Avoid driving vehicles or operating machines after taking this medicine as it may cause dizziness. Do not consume alcohol while using this medicine as it may worsen drowsiness. Zerodol Spas (100/80 mg) Tablet should be taken with food, milk, or an antacid to avoid stomach irritation. For the ease of remembering, take it at the same time every day. Do not stop using this medicine even if you feel better after taking a few doses as abrupt stopping may worsen your condition and lead to more severe symptoms. Zerodol Spas (100/80 mg) Tablet may not be suitable for all people. Inform your doctor if you have liver or kidney problems before taking this medicine. This medicine is not recommended to be used if you are pregnant or are breastfeeding. Zerodol Spas (100/80 mg) Tablet is not recommended for use in children below 12 years of age.

Side effects

Major & minor side effects for Zerodol Spas (100/80 mg) Tablet

  • Dry mouth
  • Change in pulse rate
  • Dizziness
  • Headache
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Abdominal pain
  • Constipation
  • Diarrhoea
  • Nausea and vomiting
  • Skin rash

Uses of Zerodol Spas (100/80 mg) Tablet

What is it prescribed for?

  • Muscular pain with spasm
  • Dysmenorrhea
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for Zerodol Spas (100/80 mg) Tablet to show its action is not known.
  • How long do the effects of this medicine last?
    The amount of time for which Zerodol Spas (100/80 mg) Tablet remains active in the body is not known.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended while taking Zerodol Spas (100/80 mg) Tablet due to the increased risk of stomach bleeding and ulcer formation.
  • Is this a habit forming medicine?
    No-habit forming tendency has been reported for Zerodol Spas (100/80 mg) Tablet.
  • Can this medicine be taken during pregnancy?
    Zerodol Spas (100/80 mg) Tablet is not recommended for use during pregnancy due to the risk of harmful effects on your foetus. Consult your doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    It is not known whether Zerodol Spas (100/80 mg) Tablet passes into breast milk or not. However, consult your doctor before taking this medicine.

Allergy

Avoid taking Zerodol Spas (100/80 mg) Tablet if you are allergic to it. Serious allergic reactions to this medicine are rare. However, seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Severe liver/kidney diseases

Use of Zerodol Spas (100/80 mg) Tablet should be avoided if you have any kidney or liver problems as it may increase the risk of worsening your condition.

Heart diseases

Zerodol Spas (100/80 mg) Tablet should be used with caution if you have heart problems like congestive heart failure due to the risk of complications and worsening your condition.

Asthma

Zerodol Spas (100/80 mg) Tablet should be used with caution if you have Asthma especially if you experience allergic reactions with the use of non-steroidal anti-inflammatory medicines (medicines used in the treatment of pain and fever) like aspirin.

Blood clotting disorder

Zerodol Spas (100/80 mg) Tablet may prolong the blood clotting time and therefore increase the risk of bleeding. Hence, it is not recommended for use if you have blood clotting disorders as it may worsen your condition.
Warnings for special population

Pregnancy

Zerodol Spas (100/80 mg) Tablet is not recommended for use during pregnancy due to the risk of harmful effects on your foetus. Consult your doctor before taking this medicine.

Breast-feeding

It is not known whether Zerodol Spas (100/80 mg) Tablet passes into breast milk or not. However, consult your doctor before taking this medicine.
General warnings

Liver/kidney diseases

Zerodol Spas (100/80 mg) Tablet should be used with caution if you have liver or kidney problems as it may cause serious side effects and lead to kidney/liver damage.

Hypotension

Zerodol Spas (100/80 mg) Tablet may cause hypotension (low blood pressure) if you have pre-existing heart conditions like stroke, myocardial infarction etc. Your doctor may suggest tests for monitoring your heart function while on treatment with this medicine.

CABG

Do not use Zerodol Spas (100/80 mg) Tablet for relieving pain after a CABG (coronary artery bypass graft) procedure as it may affect the clotting factors and may worsen your condition and impact the surgical outcome.

Use in children

Zerodol Spas (100/80 mg) Tablet is not recommended for use in children below 18 years of age.

Driving or operating machiners

Zerodol Spas (100/80 mg) Tablet may cause drowsiness or dizziness in some people. It is advised that you do not perform activities such as driving vehicles or operating machines if you experience any of these symptoms during treatment with this medicine.

Use in Elderly

Zerodol Spas (100/80 mg) Tablet should be used with caution in elderly people due to the increased risk of kidney and liver damage. Your doctor will generally start treatment with lower doses to check for your tolerance to this medicine.

Water retention

Zerodol Spas (100/80 mg) Tablet may cause oedema (water retention in your body's tissues majorly in lower limbs). Your doctor may suggest tests to monitor your blood pressure, electrolyte levels, and heart function while you are on treatment with this medicine based on your clinical condition.

Missed Dose

If you forget to take a dose of Zerodol Spas (100/80 mg) Tablet, make sure that you remember to take your next dose when it is due. Do not take two doses together to make up for a missed one.

Overdose

Never take more than the prescribed dose of Zerodol Spas (100/80 mg) Tablet. If you suspect that you might have taken an overdose of this medicine, seek emergency medical help.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while taking Zerodol Spas (100/80 mg) Tablet due to the increased risk of stomach bleeding and ulcer formation.
Interaction with Medicine

Lithium

Digoxin

Corticosteroids

Antihypertensives

Levodopa

Diazepam

Disease interactions

Porphyria

Porphyria is a rare disorder that mainly affects your skin or nervous system. This disorder is usually inherited, which means it is caused by gene mutations passed from parents to children. Zerodol Spas (100/80 mg) Tablet may worsen the conditions associated with photosensitivity, such as acute porphyria. Consult your doctor before using this medicine in such conditions.

Low cardiac output

Avoid using Zerodol Spas (100/80 mg) Tablet if you have a known history of low cardiac output (a condition characterized by insufficient pumping of blood from the heart) as it may worsen your condition.

Asthma

If you have NSAID-sensitive asthma, you may experience severe side effects including breathing difficulty while using Zerodol Spas (100/80 mg) Tablet as it contains aceclofenac. Your doctor may adjust the dose of this medicine or prescribe a safer alternative based on your condition.

Gastro-Intestinal toxicity

Long term use of Zerodol Spas (100/80 mg) Tablet can cause damage to the stomach and intestine. Serious conditions like bleeding, ulceration, and perforation of the stomach or intestinal wall can occur as a result of prolonged usage.

Kidney damage

Prolonged use of high doses of Zerodol Spas (100/80 mg) Tablet may cause damage to the kidney and lead to problems, such as painful urination and protein or blood in the urine. Your doctor may suggest tests for monitoring your kidney function while on treatment with this medicine.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Zerodol Spas (100/80 mg) Tablet with food to avoid stomach irritation. Never take more than the prescribed dose. Take this medicine at around the same time daily. Do not stop the use of this medicine without consulting your doctor. Take it in dose and duration prescribed by your doctor. Long-term use may lead to complications such as stomach bleeding and kidney problems. Do not drive vehicles or operate machines if you experience dizziness and drowsiness after taking this medicine. Avoid alcohol consumption while on treatment with this medicine. Do not take it with any other medicine containing Paracetamol or any drugs for pain/fever or cough-and-cold, without consulting your doctor first. Your doctor may regularly monitor your kidney, liver, heart function and levels of blood components if you are taking this medicine for a longer duration. Keep away from the reach of children and pets. Do not use it after the date of expiry.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Aceclofenac works by reducing the formation of certain substances in the body that cause pain and swelling. Drotaverine affects certain enzyme receptors that are directly involved with the spasms of the smooth muscles. It also helps in restoring the chemical balance in smooth muscles to relieve pain and spasms.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Nonsteroidal anti-inflammatory agents, Anticholinergics/antispasmodics

Schedule

Schedule H

Pubchem.ncbi.nlm.nih.gov. 2021. Aceclofenac. [online] Available at: < [Accessed 7 May 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Aceclofenac>

K.M, V. and D, A., 2021. Oral Drotaverine and Aceclofenac Combination versus Aceclofenac alone for Postoperative Pain Relief: A Prospective Randomized Clinical Trial. [online] Ijopp.org. Available at: < [Accessed 31 May 2021].

http://www.ijopp.org/article/42>

Dailymed.nlm.nih.gov. 2021. DailyMed - CLANZA CR- aceclofenac tablet, film coated. [online] Available at: < [Accessed 7 October 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8a023942-01e8-4849-aa3c-1a640ffc7fd3>

Pubchem.ncbi.nlm.nih.gov. 2021. Drotaverine. [online] Available at: < [Accessed 31 May 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Drotaverine>

Drugs.ncats.io. 2021. NCATS Inxight: Drugs — DROTAVERINE. [online] Available at: < [Accessed 7 October 2021].

https://drugs.ncats.io/drug/98QS4N58TW>
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Information on this page was last updated on 12 Oct 2021

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