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Zenflox OZ Infusion

Manufactured byMANKIND PHARMACEUTICALS LTD
ContainsOfloxacin (2 mg/ml) + Ornidazole (5 mg/ml)
Description

Zenflox OZ Infusion is a combination medicine used for the treatment of diarrhea of mixed infection in adults patients only. This medicine is not recommended for use in patients less than 18 years of age.

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Side effects

Major & minor side effects for Zenflox OZ Infusion

  • Abdominal pain
  • Anxiety
  • Black or tarry stools
  • Confusion
  • Fever
  • Painful urination
  • Decreased appetite
  • Joint pain
  • Change in taste
  • Excessive air or gas in stomach
  • Runny Nose
  • Nausea and Vomiting
  • Sleeplessness
  • Dizziness
  • Change in pulse rate
  • Difficulty in breathing
  • Shaking of the hands or feet
  • Skin rash and itching
  • Red spots on skin

Uses of Zenflox OZ Infusion

What is it prescribed for?

  • Diarrhea of mixed infection
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary since it may affect the development of the infant's joints. All the risks and benefits should be discussed with the doctor before receiving this medicine. If the medicine is used, the infant should be monitored closely for any adverse effects such as diarrhea or diaper rash.

Allergy

This medicine is not recommended for use in patients with a known allergy to ofloxacin, any other fluoroquinolones, ornidazole, or any other inactive ingredients present along with these medicines.

Tendinitis or tendon rupture

This medicine is not recommended for use in patients with a history of tendon rupture or tendinitis (a condition in which the tissue connecting muscle to the bone becomes inflamed) since it may worsen the patient's condition.

Myasthenia gravis

This medicine is not recommended for use in patients with a history of myasthenia gravis since it may worsen the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary since it may affect the development of the infant's joints. All the risks and benefits should be discussed with the doctor before receiving this medicine. If the medicine is used, the infant should be monitored closely for any adverse effects such as diarrhea or diaper rash.
General warnings

Tendinitis and Tendon ruputure

Use of this medicine will increase the risk of developing tendinitis or tendon rupture during the treatment or several months after the treatment. This may affect your shoulders, hands, ankles, or other parts of your body. You are at a higher risk if you are more than 60 years of age or if you have undergone a transplant of kidney, heart, or lung. You are also at a higher risk if you are on corticosteroids like dexamethasone, methylprednisolone, or prednisone. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Drug-resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing benefits and may even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

Photosensitivity

This medicine may make you more sensitive to sunlight or tanning lights. You are advised to use sunscreen and wear protective clothing to avoid adverse reactions to sunlight during treatment with this medicine.

Liver impairment

This medicine should be used with caution in patients with liver diseases due to the increased risk of serious adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Multiple sclerosis

This medicine should be used with extreme caution in patients suffering from this neurodegenerative disorder of the brain. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Drowsiness

This medicine may cause dizziness, drowsiness, or sleepiness and interfere with eyesight. Hence, it is advised that you do not drive a vehicle or operate heavy machinery during treatment with this medicine.

Missed Dose

Since this medicine is administered by a qualified healthcare professional, the likelihood of missing a dose is very low. If you miss a scheduled appointment for a dose of this medicine, contact your doctor for further instructions.

Overdose

Since this medicine is administered in the hospital/clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Escitalopram

Vecuronium

Warfarin

Ethinyl Estradiol

Corticosteroids

Quinidine

Aspirin

Antidiabetic drugs

Disease interactions

Central nervous system disorders

This medicine should be used with extreme caution in patients with a history of seizure disorder and other central nervous system abnormalities since it may worsen the patient's condition. Report any incidence of tremors, restlessness, anxiety, confusion, hallucinations, etc., to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Gastrointestinal Diseases

This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, since it may worsen the patient's condition. Report any incidence of severe diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

QT Prolongation

This medicine should be used with extreme caution in patients with a history of QT prolongation due to the increased risk of worsening of the patient's condition. This risk is especially higher in patients with heart diseases or electrolyte disturbances and elderly patients. Report any incidence of discomfort in the chest, heart palpitations, etc., to the doctor on priority. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of serious adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional. Inform the doctor if you have a known allergy to this medicine. Report to the doctor all your current medicines including herbs and supplements as well as all your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Ofloxacin works by inhibiting an enzyme required for the bacterial DNA to replicate; this blocks the multiplication and growth and results in the eventual death of the bacteria. Ornidazole works by inhibiting the growth of protozoa or bacteria by interfering with protein formation process, leading to the death of the bacteria or protozoa.
Legal Status

Banned

Unknown

Unknown

Unknown

Classification

Category

Fluoroquinolones, Anthelmintics

Schedule

Schedule H

Ofloxacin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 17 February 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a691005.html

Ornidazole | C7H10ClN3O3 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 1 June 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/28061#section=Top

[Internet]. 2018 [cited 6 March 2018]. Available from:

https://www.medicines.org.uk/emc/product/1668/smpc
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Information on this page was last updated on 29 Oct 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.