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Zam-MT 0.25 Tablet
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Zam-MT 0.25 Tablet

Manufactured byEast West Pharma
ContainsAlprazolam (0.25 mg) + Melatonin (3 mg)
Description
Zam-MT 0.25 Tablet is a combination medicine which may be used for the treatment of anxiety, sleeplessness, panic disorders, like unexpected extreme fear and tension due to stress. It is recommended to start with a small dosage and increase it gradually. Do not stop taking this medicine suddenly as it may cause withdrawal symptoms like seizures, aggressive behavior, blurred vision, etc.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Zam-MT 0.25 Tablet

  • Changes in pattern of speech
  • Unsteadiness
  • Loss of coordination
  • Drowsiness
  • Blurred vision
  • Abdominal pain
  • Difficult or painful urination
  • Headache
  • Chest pain
  • Irregular menstrual periods
  • Decreased appetite
  • Weight loss
  • Double vision
  • Sudden sweating
  • Acid or sour stomach
  • Heartburn
  • Day time drowsiness
  • Stomach pain

Uses of Zam-MT 0.25 Tablet

What is it prescribed for?

  • Anxiety
  • Panic disorder
  • Insomnia (Sleeplessness)
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 1-2 hours of administration of the dose.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of dizziness, difficulty in concentrating, etc. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
  • Is this a habit forming medicine?
    Habit forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to alprazolam, melatonin or any other inactive ingredients present in the formulation.

CYP3A4 inhibitors

This medicine is not recommended for use in patients who are concomitantly taking CYP3A4 inhibitors such as itraconazole, ketoconazole, etc due to the increased risk of worsening of the patient's condition.

Acute narrow-angle glaucoma

This medicine is not recommended for use in patients with acute narrow-angle glaucoma due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Drug dependence

This medicine has the potential to cause drug dependence and abuse. This risk is especially higher if the medicine is used for a prolonged period of time. Patients should be monitored closely for any change in mood and behavior during treatment with this medicine. Abrupt discontinuation is not recommended since it may cause withdrawal symptoms. Withdrawal of therapy should be done gradually with close monitoring.

Use in Children

This medicine is not recommended for use in patients below 18 years of age due to the increased risk of severe adverse effects. However, your doctor may prescribe this medicine if the benefits significantly outweigh the risks. In such a case, the patient should be monitored closely for any adverse effects.

Use in Elderly

This medicine should be used with extreme caution in individuals who are 60 years old and above due to the increased risk of sedation and muscle weakness.

Liver/Kidney Disease

This medicine should be used with caution in patients with liver/kidney diseases due to the increased risk of adverse effects. Regular monitoring of liver/kidney function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Suicidal tendencies

This medicine should be used with caution due to the increased risk of suicidal tendencies. Patients should be closely monitored for any change in mood or behavior. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Other medicines

This combination medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of dizziness, difficulty in concentrating, etc. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
Interaction with Medicine

Cetirizine

Antihypertensives

Sodium oxybate

Pentazocine

Codeine

Metoclopramide

Warfarin

Ifosfamide

Disease interactions

Seizure disorders

This medicine should be used with extreme caution in patients with seizure disorders due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Regular monitoring of liver function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Consumption of grapefruit juice is not recommended while receiving this medicine due to increased risk of adverse effects.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine with or without food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine before completion of the course/without consulting your doctor as it may cause withdrawal symptoms.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Alprazolam works by decreasing the uncontrolled, excitatory activity in the brain. Melatonin helps to send messages to the brain and other areas of the body to regulate the sleep and wake cycles in the body.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Benzodiazepines, Miscellaneous anxiolytics, sedatives and hypnotics

Schedule

Schedule H

Alprazolam - DrugBank [Internet]. Drugbank.ca. 2017 [cited 27 June 2017]. Available from:

https://www.drugbank.ca/drugs/DB00404

Alprazolam: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 23 February 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a684001.html

Melatonin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 18 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB01065

Melatonin [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 18 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Melatonin#
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Information on this page was last updated on 5 Jul 2019

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.