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Xgeva 120 mg Injection

Manufactured byDR REDDYS LABORATORIES LTD
ContainsDenosumab
Description

Xgeva 120 mg Injection is used for the treatment of osteoporosis (a condition where bone density reduces and bones becomes weak and fragile) in men and postmenopausal women who are at high risk for fractures and have failed to respond to other medication treatments for osteoporosis. It is also used for the treatment of bone loss in men with prostate cancer and women with breast cancer receiving therapy with medications that cause bone loss. This medicine also reduces the risk of fractures in patients with bone cancer and multiple myeloma (a type of blood cancer).

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Side effects

Major & minor side effects for Xgeva 120 mg Injection

  • Decreased calcium levels
  • Back pain
  • Frequent urge to urinate
  • Skin rash
  • Difficulty in breathing
  • Unusual tiredness and weakness
  • Headache
  • Bone and joint pain

Uses of Xgeva 120 mg Injection

What is it prescribed for?

  • Osteoporosis
  • Osteolytic bone metastases of solid tumors
  • Giant cell tumor of the bone
  • Hypercalcemia of malignancy
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to denosumab or any other inactive ingredients present along with it.

Hypocalcemia

This medicine is not recommended for use in patients with hypocalcemia (decreased blood calcium levels). The low blood calcium levels should be corrected with appropriate treatment in such patients before starting therapy with this medicine.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.
General warnings

Infections

Since this medicine can cause bone marrow suppression, the patients are susceptible to serious and opportunistic infections. Report any symptoms such as a fever, chills, shortness of breath, sore throat, etc. to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Calcium and vitamin D supplementation

It is recommended to take supplementation containing calcium and Vitamin D in patients receiving this medicine unless hypercalcemia (increased blood calcium levels) is present.

Hypocalcemia

This medicine may lower the blood calcium levels and hence should be used with extreme caution in patients who are predisposed to hypocalcemia (decreased blood calcium levels). The low blood calcium levels should be corrected with appropriate treatment in such patients before starting therapy with this medicine. Close monitoring of blood calcium levels, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Osteonecrosis of the jaw (ONJ)

This medicine may cause osteonecrosis of the jaw (ONJ) on therapy in some patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Severe bone, muscle and/or joint pain

This medicine may cause severe bone, muscle and/or joint pain on therapy in some patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low. If you miss any scheduled session, contact your doctor immediately for further instructions.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Zidovudine

Adalimumab

Etelcalcetide

Cyclophosphamide

Disease interactions

Immunosuppression

This medicine should be used with caution in patients with weak immunity or who receives immune-suppressing medications since it may increase the risk of infections. Close monitoring of the clinical condition, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by inhibiting certain proteins that cause bone resorption and bone mass depletion.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Miscellaneous bone resorption inhibitors, Antineoplastics

Schedule

Schedule H

DailyMed - Prolia - denosumab injection [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 30 May 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=49e5afe9-a0c7-40c4-af9f-f287a80c5c88

DailyMed - Xgeva- denosumab injection [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 30 May 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=628f0998-1206-4001-aeee-18133aa9f3bf

Denosumab - DrugBank [Internet]. Drugbank.ca. 2019 [cited 30 May 2019]. Available from:

https://www.drugbank.ca/drugs/DB06643

Prolia - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2019 [cited 30 May 2019]. Available from:

https://www.medicines.org.uk/emc/product/568/smpc

Denosumab Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 30 May 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a610023.html
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Information on this page was last updated on 30 May 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.