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Volibose Trio 2 Tablet

Manufactured bySaan Labs
ContainsGlimepiride (2 mg) + Metformin (500 mg) + Voglibose (0.2 mg)
Description

Volibose Trio 2 Tablet is a combination medicine used to control high blood glucose levels in patients with type 2 diabetes mellitus. Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect.

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Side effects

Major & minor side effects for Volibose Trio 2 Tablet

  • Nausea and vomiting
  • Diarrhea
  • Abdominal pain
  • Low blood sugar levels (hypoglycaemia)
  • Weakness
  • Chest discomfort
  • Headache
  • Runny Nose
  • Swollen joints
  • Dizziness
  • Flu like symptoms
  • Allergic skin reaction
  • Jaundice
  • Weight gain

Uses of Volibose Trio 2 Tablet

What is it prescribed for?

  • Type II Diabetes Mellitus
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol during treatment with this medicine may increase the risk of severe side effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Severe kidney impairment

This medicine is not recommended for use in patients with a severe impairment of kidney function due to the increased risk of serious adverse effects.

Metabolic Acidosis

This medicine is not recommended for use in patients with metabolic acidosis due to the increased risk of worsening of the patient's condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to glimepiride, other sulphonamide derivatives, metformin, voglibose or any other ingredients present in the formulation.

Digestive disorders

This medicine is not recommended for use in patients having long-term digestive disorders due to the increased risk of conditions like Gastroesophageal reflux disorder, Inflammatory bowel disorder, heartburn, etc.

Intestinal Obstruction

This medicine is not recommended for use in patients having intestinal obstruction due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Lactic Acidosis

This medicine may cause lactic acidosis, which may be fatal, in some patients. This risk is especially higher in patients suffering from heart diseases, kidney diseases, etc. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition.

Kidney disease

This medicine should be used with extreme caution in patients with kidney diseases due to the increased risk of worsening of the patient's condition. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Type I diabetes

This medicine is not recommended for use in patients suffering from Type I diabetes since it is not effective in treating such patients.

Diarrhea

This medicine may cause diarrhea when therapy is initiated. In most cases, diarrhea subsides by itself. Contact your doctor if the problem persists for longer durations. Therapy may need to be discontinued in some cases based on the clinical condition.

Vitamin B12 deficiency

This medicine should be used with extreme caution in patients with vitamin B12 deficiency since it may worsen the patient's condition. Appropriate vitamin B12 supplementation and dose adjustments may be required in some cases.

Stress

Use of this medicine should be discontinued in patients exposed to stressful conditions such as a fever, trauma, surgeries, or accidents since it may not be effective in controlling blood sugar levels in these conditions. Replacement with a suitable alternative should be considered under your doctor's supervision.

Fluid Retention and Edema

This medicine should be used with caution in patients with fluid retention and edema due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Weight gain

This medicine may cause a mild to moderate weight gain in some patients.

Photo-sensitivity

This medicine may cause allergic skin reactions on exposure to sunlight in some patients. Patients are advised to use sunscreen and wear protective clothing to avoid these reactions. Replacement with a suitable alternative may be required if the reactions are severe.

Use in Children

This medicine is not recommended for use in children Since the safety and efficacy of use are not clinically established.

Liver Disease

This medicine should be used with extreme caution in patients with liver diseases due to the increased risk of worsening of the patient's condition. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Gastrointestinal Diseases

This medicine is not recommended for use in patients with any gastrointestinal diseases like inflammatory bowel disease, colonic ulceration, partial intestinal obstruction, or any chronic intestinal disease. It is advised that you should inform the doctor about all your medical conditions before starting treatment with this medicine.

Diabetic ketoacidosis

This medicine should be used with extreme caution in patients with diabetic ketoacidosis due to the increased risk of severe adverse effects. Close monitoring of blood glucose levels and vital signs is recommended for such patients. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Change of medicines

You may experience some temporary side effects if there is a change in the current medications used for diabetes mellitus. This overlapping effect is because of the change from one medicine to another. Close monitoring of blood sugar levels is recommended in these cases.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol during treatment with this medicine may increase the risk of severe side effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
Interaction with Medicine

Amlodipine

Diclofenac

Estradiol

Fluconazole

Gatifloxacin

Miconazole

Rifampicin

Colesevelam

Insulin

Iodinated Contrast Media

Aloe Vera

Disease interactions

Vitamin B12 deficiency

This medicine should be used with extreme caution in patients with vitamin B12 deficiency since it may worsen the patient's condition. Appropriate vitamin B12 supplementation and dose adjustments may be required based on the clinical condition.

Heart disease

This medicine should be administered with extreme caution in patients suffering from heart diseases or diseases of the blood vessels due to the increased risk of severe adverse effects. Close monitoring of heart function and vital signs is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney disease

This medicine should be used with extreme caution in patients with an impaired kidney function due to an increase in the risk of kidney injuries. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Liver disease

This medicine should be used with caution in patients with an impaired liver function due to an increase in the risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hypoglycemia

This medicine should be administered with caution in patients prone to having low blood glucose level episodes. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hemolytic Anemia/G6PD Deficiency

This medicine is not recommended for use in patients with a history of Hemolytic Anemia or patients with G6PD deficiency due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions

Elevated ALT

Report the use of this medicine to the doctor if you are undergoing this test. A false positive result may be obtained if this test is performed while taking this medicine. Do not stop the use of any medicine without consulting your doctor.
Take this medicine exactly as prescribed by the doctor. It is advised to take this medicine just before meals. Your dose is likely to change over time based on therapeutic response and clinical condition. Regular monitoring of blood sugar levels is recommended during treatment with this medicine. You should always carry a sugar candy with you to counteract unexpected lowering of blood sugar levels. Do not change the dose or duration of use without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Glimepiride increases the secretion of insulin from the pancreas and also regulates the glucose from the liver. Metformin decreases absorption of glucose from the intestines and increases the action of insulin in the body. Voglibose works by reducing the blood glucose level by preventing the breakdown of large carbohydrates into glucose. Their combination is thus effective in reducing the blood glucose levels.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Sulfonylureas, Oral Biguanides, Alpha-glucosidase inhibitors, Oral anti-diabetic combinations

Schedule

Schedule H

Glimepiride - DrugBank [Internet]. Drugbank.ca. 2018 [cited 20 August 2018]. Available from:

https://www.drugbank.ca/drugs/DB00222

Glimepiride [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 20 August 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/3476#

Metformin [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 20 August 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/4091#

Voglibose [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 20 August 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/444020#
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Information on this page was last updated on 22 Mar 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.