Vingraf 1 MG Capsule

• Missed Dose

  If you miss a dose of Vingraf 1 MG Capsule, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

• Overdose

  Seek emergency medical treatment or contact the doctor in case of an overdose.

Warnings for special population

• Pregnancy

  - This medicine is not recommended for pregnant women unless necessary. The benefits and risks should be discussed with the doctor before taking this medicine.

• Breast-feeding

  - This medicine is known to excreted in breast milk. It is not recommended in breastfeeding women unless necessary. The benefits and risks should be discussed with the doctor before taking this medicine.

General warnings

• Malignancy

  - This medicine may increase the risk of lymphoma and other malignancies. Doctors should inform patients about these risks and advise the patient to [revent exposure of the sunlight by wearing protective clothes.

• Serious infections

  - The chances of occurring infections are more in the patients receiving this medicine. Hold the treatment and start with the broad-spectrum antibiotics if there are any signs and symptoms of fever. Close monitoring of the body temperature and the blood cell count is necessary.

• Liver impairment

  - This medicine is not recommended in the patients with a history of liver impairment. The concentration of this medicine may increase in these patients. The baseline of the liver function tests should be obtained before starting the treatment.

• Kidney impairment

  - This medicine is not recommended in the patients with a history kidney impairment. Close monitoring of kidney function is necessary. The dose should be adjusted based on the creatine clearance (CrCl).

• Hypertension

  - Use with caution in hypertensive patients. Appropriate antihypertensives should be administered to control the blood pressure. Do not use medicine that may increase the potassium levels.

• Hyperkalemia

  - This medicine may increase the levels of potassium in the body and may increase the risk of arrhythmia. Close monitoring of potassium levels is necessary. Medicines that can increase the potassium levels like ACE inhibitors and potassium-sparing diuretics should be avoided.

• Can be taken with or without food, as advised by your doctor
• To be taken as instructed by doctor
• May cause sleepiness

• [Internet]. 2017 [cited 5 May 2017]. Available from: https://www.medicines.org.uk/emc/medicine/23205
• Tacrolimus: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 5 May 2017]. Available from: https://medlineplus.gov/druginfo/meds/a601117.html
• DailyMed - tacrolimus capsule [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 5 May 2017]. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bd447ffa-9196-4c3c-accf-5adf29b84665
• Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 5 May 2017]. Available from: https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname
• [Internet]. 2017 [cited 5 May 2017]. Available from: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~zoAykC:1