Urokinase

Description

Urokinase is a thrombolytic medicine which is used for lysing or dissolving unwanted blood clots. It is used in the management of deep vein thrombosis (blood clot in the deep veins of the body) and blood clots affecting the blood vessels of the lungs. This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

Side effects

Major & minor side effects for Urokinase

  • Bleeding and bruising at injection site
  • Blurred vision
  • Fast heart rate
  • Bleeding from nose and gums
  • Bloody or tarry stools
  • Red or pink urine
  • Numbness
  • Weakness
  • Severe headache
  • Severe stomach pain
  • Chest tightness
  • Shortness of breath
  • High blood pressure
  • Nausea and vomiting

Uses of Urokinase

What is it prescribed for?

  • Pulmonary embolism
  • Deep Vein Thrombosis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to urokinase or any other inactive ingredients present along with it.

Bleeding

This medicine is not recommended for use in patients who have a current intracranial hemorrhage, subarachnoid hemorrhage, active internal bleeding, or underwent any intracranial or intraspinal surgery or serious head trauma within the past 2 months due to the increased risk of worsening of the patient's condition.

Severe uncontrolled hypertension

This medicine is not recommended for use in patients with severe uncontrolled hypertension due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Severe bleeding

This medicine may increase the risk of bleeding, therefore should be used with caution in patients with any bleeding disorder. Inform the doctor if you have any gastrointestinal diseases, previous history of trauma, surgery, stroke or uncontrolled hypertension. Close monitoring is necessary and therapy should be discontinued in case of any signs of internal bleeding.

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Severe allergic reactions

This medicine may cause severe allergic reactions including anaphylactic reactions such as bronchospasm, urticaria, etc. in some patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Other uses

Your doctor may use this medicine for indications other than those stated above in certain specific circumstances, especially if other medicines are not effective. All the risks and benefits should be discussed with the doctor in such cases.

Cerebrovascular diseases

This medicine should be used with extreme caution in patients with a known history of cerebrovascular diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

High blood pressure

This medicine should be used with extreme caution in patients with severe hypertension (high blood pressure) due to the increased risk of worsening of the patient's condition. Frequent monitoring of blood pressure is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Missed Dose

Since this medicine is administered in the hospital or clinic setting by a qualified healthcare professional, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Escitalopram

Nonsteroidal anti-inflammatory drugs

Angiotensin converting enzyme inhibitors (ACEI's)

Anticoagulants

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional in the clinic or hospital setting. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Effect on sleep is not established

How it works
This medicine increases the formation of an enzyme (plasmin) which is responsible for the breakdown of blood clots.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Thrombolytics, Antithrombotic Agents

Schedule

Schedule H

[Internet]. Drugbank.ca. 2018 [cited 28 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00013

[Internet]. Mhra.gov.uk. 2018 [cited 28 December 2018]. Available from:

http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con108649.pdf

DailyMed - Kinlytic- urokinase injection, powder, lyophilized, for solution [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 15 March 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bfe5cfb9-591d-4df8-12a3-6555cde3185d

Syner-Kinase 100,000 IU - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2019 [cited 15 March 2019]. Available from:

https://www.medicines.org.uk/emc/product/7565/smpc

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Information on this page was last updated on 15 Mar 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.