Ulinastatin

Description

Ulinastatin is a protease inhibitor used for the treatment of severe sepsis and mild to severe acute pancreatitis. This medicine is not recommended for use in patients less than 18 years of age.

Side effects

Major & minor side effects for Ulinastatin

  • Chills
  • Chest pain
  • Nausea
  • Vomiting
  • Abdominal pain
  • Fast or slow heartbeat
  • Rash
  • Itching of skin
  • Shortness of breath
  • Injection site reations (pain,swelling)

Uses of Ulinastatin

What is it prescribed for?

  • Sepsis
  • Acute pancreatitis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required by this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time. Alternatively, your doctor may prescribe a suitable alternative based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to ulinastatin or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time. Alternatively, your doctor may prescribe a suitable alternative based on your clinical condition.
General warnings

Use in Pediatrics

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Intravenous Administration

This medicine is not recommended for administration as a bolus/IV push. It should be administered as an infusion over a period of one hour.

Liver diseases

This medicine should be used with caution in patients with a history of liver diseases due to the increased risk worsening of the patient's condition. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the patient's condition.

Other medicines

This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is recommended that you report to the doctor all your current medicines, including any herbs and supplements, before receiving therapy with this medicine.

Missed Dose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Abacavir

Clomipramine

Clarithromycin

Aminophylline

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered only by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It works by inhibiting certain chemical substances that are responsible for causing pain, swelling, redness, cell damage, etc.
Legal Status

Approved

Unknown

Approved

Unknown

Classification

Category

Protease inhibitors

Schedule

Schedule H

Ulinastatin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 21 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB12038

Ulinastatin [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 21 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Urinastatin#

[Internet]. Bharatserums.com. 2018 [cited 21 September 2018]. Available from:

https://www.bharatserums.com/product/critical/U-Tryp%20(Liquid)%20Common%20Pack%20Insert%20for%20Domestic.pdf

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Information on this page was last updated on 1 Oct 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.