Trimipramine
Description
Trimipramine is a tricyclic antidepressant used to treat depression. It should be started at lower doses and gradually increased. Do not stop taking this medicine suddenly as it may cause withdrawal symptoms like mood changes and irritability.
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Side effects
Major & minor side effects for Trimipramine
- Confusion
- Dizziness
- Sleeplessness
- Headache
- Loss of appetite
- Nausea and vomiting
- Dry mouth
- Constipation
- Ringing or buzzing in the ears
Uses of Trimipramine
What is it prescribed for?
- Depression
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Concerns
Commonly asked questions
- Onset of actionThe amount of time taken by this medicine to show its effect is subject to vary based on the individuals.
- Duration of effectThe amount of time for which this medicine remains effective in the body is subject to vary based on individuals.
- Safe with alcohol?Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
- Is it habit forming?No habit-forming tendencies were reported.
- Usage in pregnancy?This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
- Usage while breast-feeding?This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
Allergy
This medicine is not recommended for use in patients with a known allergy to Trimipramine or any other inactive ingredients present along with it.
Monoamine oxidase inhibitors (MAOI)
This medicine is not recommended for use in patients taking monoamine oxidase inhibitors (MAOI) due to the increased risk of serious and life-threatening side effects. A time gap of at least 14 days should be maintained between the administration of these medicines.
Narrow-angle glaucoma
This medicine is not recommended for use in patients with narrow-angle glaucoma due to the increased risk of worsening of the patient's condition.
Myocardial infarction
This medicine is not recommended for use in patients with a recent myocardial infarction (MI) due to the increased risk of worsening of the patient's condition.
QT Interval Prolonging Drugs
This medicine is not recommended for use in patients who are concomitantly taking medicines or with conditions that prolong the QT interval due to the increased risk of worsening of the patient's condition.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings
Withdrawal symptoms
The use of this medicine should not be discontinued abruptly. You may experience withdrawal symptoms especially if you have been using a high dose for a long duration. Do not stop the use of this medicine without consulting your doctor.
Suicidal tendencies
This medicine should be used with caution due to the increased risk of suicidal tendencies. This risk is especially higher in young patients. Patients should be closely monitored for any change in mood or behavior. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Driving or operating machinery
Use of this medicine may cause dizziness or impair alertness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
Use in children
This medicine is not recommended for use in patients less than 12 years of age since the safety and efficacy of use are not clinically established.
Anticholinergic effects
This medicine should be used with caution in patients with preexisting conditions of anticholinergic activity such as urinary retention, angle-closure glaucoma, gastrointestinal obstructive disorders due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Bone marrow suppression
This medicine should be used with caution in patients with bone marrow suppression due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Missed Dose
Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
N/A
Instructions
Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine
Ondansetron
Bupropion
Ziprasidone
Efavirenz
Cisapride
Ceritinib
Disease interactions
Pheochromocytoma
This medicine should be used with caution in patients with pheochromocytoma (tumor of the adrenal gland) due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Seizure disorders
This medicine should be used with caution in patients with seizure disorders due to the increased risk of worsening of the patient's condition. Using this medicine can cause more frequent and severe episodes of seizures. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Liver impairment
This medicine should be used with caution in patients with liver impairment due to the increased risk of adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Kidney impairment
This medicine should be used with caution in patients with kidney impairment due to the increased risk of adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Cardiovascular disorders
This medicine should be used with extreme caution in patients with severe cardiovascular disorders due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Diabetes
This medicine should be used with caution in patients with diabetes due to the increased risk of worsening of the patient's condition. Close monitoring of blood glucose levels, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Hyperthyroidism
This medicine should be used with caution in patients with hyperthyroidism (a condition where the thyroid gland produces too much thyroid hormones) due to the increased risk of worsening of the patient's condition. Close monitoring of thyroid function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with or without food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking this medicine without informing the doctor as it may cause withdrawal symptoms like nausea and headache.
Miscelleneous
How it works
It works by increasing the amount of a chemical substance in the brain which helps in maintaining the mental balance.
Legal Status
Classification
Category
Tricyclic antidepressants
Schedule
Schedule H
[Internet]. Accessdata.fda.gov. 2018 [cited 7 December 2018]. Available from:
Trimipramine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 7 December 2018]. Available from:
Trimipramine 10mg Tablets - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 7 December 2018]. Available from:
Trimipramine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 7 December 2018]. Available from:
Information on this page was last updated on 28 Mar 2019
Disclaimer
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