Trimipramine

Description

Trimipramine is a tricyclic antidepressant used to treat depression. It should be started at lower doses and gradually increased. Do not stop taking this medicine suddenly as it may cause withdrawal symptoms like mood changes and irritability.

Side effects

Major & minor side effects for Trimipramine

  • Confusion
  • Dizziness
  • Sleeplessness
  • Headache
  • Loss of appetite
  • Nausea and vomiting
  • Dry mouth
  • Constipation
  • Ringing or buzzing in the ears

Uses of Trimipramine

What is it prescribed for?

  • Depression
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time taken by this medicine to show its effect is subject to vary based on the individuals.
  • Duration of effect
    The amount of time for which this medicine remains effective in the body is subject to vary based on individuals.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to Trimipramine or any other inactive ingredients present along with it.

Monoamine oxidase inhibitors (MAOI)

This medicine is not recommended for use in patients taking monoamine oxidase inhibitors (MAOI) due to the increased risk of serious and life-threatening side effects. A time gap of at least 14 days should be maintained between the administration of these medicines.

Narrow-angle glaucoma

This medicine is not recommended for use in patients with narrow-angle glaucoma due to the increased risk of worsening of the patient's condition.

Myocardial infarction

This medicine is not recommended for use in patients with a recent myocardial infarction (MI) due to the increased risk of worsening of the patient's condition.

QT Interval Prolonging Drugs

This medicine is not recommended for use in patients who are concomitantly taking medicines or with conditions that prolong the QT interval due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Withdrawal symptoms

The use of this medicine should not be discontinued abruptly. You may experience withdrawal symptoms especially if you have been using a high dose for a long duration. Do not stop the use of this medicine without consulting your doctor.

Suicidal tendencies

This medicine should be used with caution due to the increased risk of suicidal tendencies. This risk is especially higher in young patients. Patients should be closely monitored for any change in mood or behavior. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Driving or operating machinery

Use of this medicine may cause dizziness or impair alertness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Use in children

This medicine is not recommended for use in patients less than 12 years of age since the safety and efficacy of use are not clinically established.

Anticholinergic effects

This medicine should be used with caution in patients with preexisting conditions of anticholinergic activity such as urinary retention, angle-closure glaucoma, gastrointestinal obstructive disorders due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Bone marrow suppression

This medicine should be used with caution in patients with bone marrow suppression due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Ondansetron

Bupropion

Ziprasidone

Efavirenz

Cisapride

Ceritinib

Disease interactions

Pheochromocytoma

This medicine should be used with caution in patients with pheochromocytoma (tumor of the adrenal gland) due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Seizure disorders

This medicine should be used with caution in patients with seizure disorders due to the increased risk of worsening of the patient's condition. Using this medicine can cause more frequent and severe episodes of seizures. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Liver impairment

This medicine should be used with caution in patients with liver impairment due to the increased risk of adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Kidney impairment

This medicine should be used with caution in patients with kidney impairment due to the increased risk of adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Cardiovascular disorders

This medicine should be used with extreme caution in patients with severe cardiovascular disorders due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Diabetes

This medicine should be used with caution in patients with diabetes due to the increased risk of worsening of the patient's condition. Close monitoring of blood glucose levels, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Hyperthyroidism

This medicine should be used with caution in patients with hyperthyroidism (a condition where the thyroid gland produces too much thyroid hormones) due to the increased risk of worsening of the patient's condition. Close monitoring of thyroid function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with or without food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking this medicine without informing the doctor as it may cause withdrawal symptoms like nausea and headache.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by increasing the amount of a chemical substance in the brain which helps in maintaining the mental balance.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Tricyclic antidepressants

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2018 [cited 7 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/016792s037lbl.pdf

Trimipramine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 7 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00726

Trimipramine 10mg Tablets - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 7 December 2018]. Available from:

https://www.medicines.org.uk/emc/product/2961/smpc

Trimipramine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 7 December 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a602010.html

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Information on this page was last updated on 28 Mar 2019

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.