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Trilosar 12.5 Tablet

Manufactured byTORRENT PHARMACEUTICALS LTD
ContainsAmlodipine (5 mg) + Losartan (50 mg) + Chlorthalidone (12.5 mg)
Description

Trilosar 12.5 Tablet is a combination medicine used for the treatment of high blood pressure. Frequent monitoring of blood pressure and electrolytes levels is while taking this medicine. Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect. This medicine is not recommended for use in patients below 18 years of age.

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Side effects

Major & minor side effects for Trilosar 12.5 Tablet

  • Stomach pain
  • Chills
  • Difficulty or painful urination
  • Back pain
  • Chest tightness
  • Weakness in arms, hands, legs or feet
  • Nasal congestion
  • Sore throat
  • Drowsiness
  • Cough
  • Low blood sugar levels (hypoglycaemia)
  • Muscle pain
  • Sweating
  • Loss of appetite
  • Nausea
  • Vomiting
  • Headache
  • Dizziness
  • Blurred vision

Uses of Trilosar 12.5 Tablet

What is it prescribed for?

  • Hypertension
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 2 hours of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 24 to 72 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to amlodipine, losartan, chlorthalidone, other sulfonamides, or any other inactive ingredients present in the formulation.

Aliskiren

Coadministration of aliskiren and this combination of medicine is not recommended due to the increased risk of serious adverse effects. This risk is especially higher in the elderly population and in patients with diabetes and kidney diseases.

Anuria

This medicine is not recommended for use in patients with anuria (a condition where the kidney is unable to produce urine) due to the increased risk of worsening of the patient's condition.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment (CrCl < 30 ml/min) due to the increased risk of serious adverse effects.

Severe liver impairment

This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
General warnings

Hypotension

Symptomatic hypotension may occur in patients with volume depletion or patients who are treated with high-dose diuretics. It is advised to correct this condition before initiating treatment with this combination medicine.

Hyperkalemia

This medicine may increase potassium levels in the blood (hyperkalemia). This may cause serious side effects such as fatal cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (ACE inhibitors and potassium supplements) during treatment with this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Driving or operating machinery

Use of this medicine may cause symptoms such as drowsiness, blurred vision, or dizziness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating heavy machinery during treatment with this medicine if you experience any of these symptoms.

Volume and electrolyte disturbances

This medicine may alter the blood volume and electrolyte levels in some patients. This may cause dizziness, dry mouth, and acid-base imbalance. This risk is especially higher in patients suffering from kidney and liver diseases. Close monitoring of blood pressure and electrolyte levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Cisapride

Dexamethasone

Itraconazole

Lithium

Amiodarone

Rifampicin

Captopril

Insulin

Nonsteroidal anti-inflammatory medicines

Benazepril

Ziprasidone

Perindopril

Disease interactions

Congestive heart failure

This medicine should be used with extreme caution in patients with congestive heart failure due to the increased risk of kidney impairment and worsening of the patient's condition. Close monitoring of heart function, blood pressure, and kidney function is recommended for such patients. Replacement with a suitable alternative may be required based on the clinical condition.

Diabetes Mellitus

This medicine should be used with caution in patients with diabetes mellitus due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is advised for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hypotension or cardiogenic shock

This medicine is not recommended for use in patients with hypotension or cardiogenic shock due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Coronary Artery Disease

This medicine should be used with caution in patients with coronary artery disease due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hyperuricemia

This medicine should be used with caution in patients with hyperuricemia since this medicine decreases the uric acid excretion and increase the risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hyperlipidemia

This medicine should be used with caution in patients with hyperlipidemia since it may increase the cholesterol and triglyceride levels. Close monitoring of cholesterol and triglyceride levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with this medicine due to the increased risk of severe adverse effects such as dizziness, headache, etc.
It is recommended to avoid a high potassium diet during treatment with this medicine due to the increased risk of serious adverse effects. Your doctor/dietitian will suggest appropriate changes in your diet to avoid high intake of potassium.
Lab interactions
Information not available.
Take this medicine exactly as advised by your doctor. Do not take in larger amounts than prescribed. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary while taking this medicine. Report any adverse effects to the doctor on priority. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Amlodipine and Losartan both relaxes the blood vessels, thus improving blood flow and reducing blood pressure levels. Chlorthalidone works by increasing the excretion of water and sodium from the kidneys. This helps in bringing down the blood pressure as well as swelling. Their combination is thus effective in treating hypertension.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antihypertensive combinations, Calcium channel blocking agents, Angiotensin receptor blockers, Thiazide diuretics

Schedule

Schedule H

Chlorthalidone: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 19 October 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682342.html

Chlorthalidone - DrugBank [Internet]. Drugbank.ca. 2017 [cited 19 October 2017]. Available from:

https://www.drugbank.ca/drugs/DB00310

DailyMed - Losartan- losartan potassium tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 8 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3cdcf8cc-4964-4c53-e054-00144ff88e88

Losartan: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 8 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a695008.html

DailyMed - Amlodipine - amlodipine tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 7 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1cec7a02-b7a5-49e1-ab64-3a4dab4149d2

Amlodipine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 7 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a692044.html
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Information on this page was last updated on 25 Apr 2019

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.