Trifluoperazine

Description

Trifluoperazine is an antipsychotic medicine that is used to treat symptoms of schizophrenia as well as for the short-term treatment of anxiety. This medicine is not recommended for use in patients less than 6 years of age.

Side effects

Major & minor side effects for Trifluoperazine

  • Fever
  • Dizziness
  • Headache
  • Confusion
  • Sleeplessness
  • Dry mouth
  • Constipation
  • Nausea
  • Vomiting

Uses of Trifluoperazine

What is it prescribed for?

  • Schizophrenia
  • Anxiety
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Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed within 2 to 4 hours of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 4 to 6 hours.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects such as confusion, dizziness, nausea, vomiting, weakness, fainting, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to trifluoperazine, any phenothiazines, or any other inactive ingredients present along with this medicine.

CNS Depression

This medicine is not recommended for use in patients suffering from severe central nervous system depression or coma due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Seizures

This medicine should be used with extreme caution in patients suffering from seizure disorder due to the increased risk of recurrent seizures. Report any unusual symptoms to the doctor immediately. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Use in Pediatrics

This medicine is not recommended for use in patients less than 6 years of age since the safety and efficacy of use are not clinically established.

Driving and Operating machinery

Use of this medicine may cause symptoms such as dizziness, blurred vision, confusion, drowsiness, etc. in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Dementia

This medicine is not recommended for use in patients suffering from dementia due to the increased risk of serious adverse effects including death. This risk is especially higher in the elderly patients. Replacement with a suitable alternative should be considered based on the clinical condition of the patient.

Missed Dose

Oral form: Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one. Injection: Since this medicine is usually administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of missing a dose is very low.

Overdose

Oral form: Seek emergency medical treatment or contact the doctor in case of an overdose. Injection: Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects such as confusion, dizziness, nausea, vomiting, weakness, fainting, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
Interaction with Medicine

Bupropion

Citalopram

Clozapine

Amiodarone

Bedaquiline

Ceritinib

Disease interactions

Liver Disease

This medicine should be used with extreme caution in patients suffering from liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Neuroleptic Malignant Syndrome (NMS)

This medicine should be used with extreme caution in patients with a history of neuroleptic malignant syndrome due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Renal Dysfunction

This medicine should be used with extreme caution in patients suffering from kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Seizure disorders

This medicine should be used with extreme caution in patients suffering from seizure disorder due to the increased risk of worsening of the paitent's condition. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Tardive Dyskinesia

This medicine should be used with extreme caution in patients with a history of Tardive Dyskinesia due to the increased risk of recurrent symptoms. This risk is especially higher in the elderly female patients. Report any symptoms such as uncontrolled movements of the tongue, mouth, lips, jaw, hands, feet, etc. to your doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Oral form: Take this medicine with or without food, as advised by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor. Injection: This medicine should be administered by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines including any herbs and supplements as well as your medical conditions before receiving this medicine.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by inhibiting the release of certain chemical substances in the brain which are responsible for causing anxiety and the symptoms of schizophrenia.
Legal Status

Approved

Approved

Approved

Unknown

Classification

Category

Phenothiazine antipsychotics

Schedule

Schedule H

Trifluoperazine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 26 July 2018]. Available from:

https://www.drugbank.ca/drugs/DB00831

[Internet]. Medicines.org.uk. 2018 [cited 26 July 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.438.pdf

Trifluoperazine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 26 July 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a682121.html

[Internet]. Mhra.gov.uk. 2018 [cited 26 July 2018]. Available from:

http://www.mhra.gov.uk/home/groups/spcpil/documents/spcpil/con1501220904643.pdf

DailyMed - Trifluoperazine hydrochloride tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 26 July 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c2575a86-19e5-44df-8603-ff066bb9c9c5

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Information on this page was last updated on 9 Aug 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.