Triclofos

Description

Triclofos is used in the short-term treatment of insomnia, a condition characterized by difficulty falling and staying asleep. This medicine is mainly used in children for procedural sedation, a technique to manage the pain and anxiety while performing a diagnostic or therapeutic procedure by inducing sleep.

Side effects

Major & minor side effects for Triclofos

  • Nausea and vomiting
  • Drowsiness
  • Abdominal pain
  • Decreased appetite
  • Headache
  • Spinning sensation
  • Confusion
  • Skin rash
  • Diarrhea

Uses of Triclofos

What is it prescribed for?

  • Insomnia
  • Procedural sedation
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 30 minutes of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 7 to 12 hours.
  • Safe with alcohol?
    Consumption of alcohol is not recommended while receiving this medicine due to the increased risk of central nervous system side effects such as dizziness, drowsiness, and difficulty concentrating. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating heavy machinery if you consume alcohol during treatment with this medicine.
  • Is it habit forming?
    This medicine may become habit-forming if used for a prolonged period of time.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to triclofos, or any other inactive ingredients present along with it.

Renal impairment

This medicine is not recommended for use in patients with renal impairment due to the increased risk of worsening of the patient's condition.

Liver impairment

This medicine is not recommended for use in patients with liver impairment due to the increased risk of worsening of the patient's condition.

Severe cardiac disease

This medicine is not recommended for use in patients with severe cardiac diseases due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Concomitant use with opioids

This medicine should be used with extreme caution due to the increased risk of side effects such as profound sedation, respiratory depression, coma, and death. This risk is especially higher if this medicine is used along with opioids. Close monitoring of the patient for any severe side effects is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Withdrawal symptoms

This medicine may cause withdrawal syndrome after discontinuation of therapy. This risk is especially higher if the treatment is discontinued abruptly. Seek emergency medical treatment in case of any unusual symptoms such as extreme anxiety, irritability, muscle pain, confusion, restlessness, etc. Do not stop the use of this medicine without consulting your doctor.

Dependency

This medicine has the tendency to cause dependency and abuse particularly after prolonged use or excessive dosages. Individuals with a history of alcohol or substance abuse should be treated carefully when they are on this medicine. The withdrawal of this medicine should be tapered off gradually.

Depression

This medicine should be used with extreme caution in the patients with the history of depression or a family history of depression due to the risk of worsening of the condition. Any symptoms of mood changes should be reported to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Driving and operating machinery

Use of this medicine may cause dizziness or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember it. It is advised that you do not take this medicine during the daytime. If it is daytime, skip the missed dose and continue with your regular dosing schedule at bedtime. Do not double the dose to make up for a missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while receiving this medicine due to the increased risk of central nervous system side effects such as dizziness, drowsiness, and difficulty concentrating. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating heavy machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Benzodiazepines

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as advised by your doctor. It can be taken with or without food. Do not take in larger amounts than prescribed. Consult the doctor if you experience any undesirable effects. Do not stop the use of this medicine without consulting your doctor. Abrupt discontinuation of this medicine may cause severe withdrawal symptoms.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
It works by decreasing the excitability of brain cells and induces sleep.
Legal Status

Approved

Unknown

Approved

Unknown

Classification

Category

Hypnotic and sedative agent

Schedule

Schedule H

Triclofos [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 6 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/triclofos

Triclofos [Internet]. Old.trickcyclists.co.uk. 2018 [cited 6 September 2018]. Available from:

http://old.trickcyclists.co.uk/pocket_psych/BNF/anxiolytics/triclofos.htm

TRICLOFOS - National Library of Medicine HSDB Database [Internet]. Toxnet.nlm.nih.gov. 2018 [cited 6 September 2018]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+3276

Procedural Sedation in Children� What is Recommended? [Internet]. Indianpediatrics.net. 2018 [cited 6 September 2018]. Available from:

https://www.indianpediatrics.net/may2013/may-517-519.htm

Efficacy and safety of oral triclofos as sedative for children undergoing sleep electroencephalogram: An observational study [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 6 September 2018]. Available from:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991147/

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Information on this page was last updated on 12 Jun 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.