Tri Enselin Tablet

Manufactured byTORRENT PHARMACEUTICALS LTD
ContainsMetformin (500 mg) + Glibenclamide (5 mg) + Rosiglitazone (2 mg)
Description

Tri Enselin Tablet is a combination medicine used to control high blood glucose levels in patients with type 2 diabetes. Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect.

Substitutes

List of substitutes for Tri Enselin Tablet

Side effects

Major & minor side effects for Tri Enselin Tablet

  • Abdominal fullness
  • Yellowing of skin and eyes
  • Dark colored urine
  • Fever or chills
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Unusual bleeding
  • Fast heartbeat
  • Unusual tiredness and weakness
  • Nausea and vomiting
  • Diarrhea
  • Abdominal pain
  • Hypoglycemia
  • Chest discomfort
  • Headache
  • Runny Nose
  • Belching and Heartburn

Uses of Tri Enselin Tablet

What is it prescribed for?

  • Type II Diabetes Mellitus
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 15-60 minutes of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 24 hours.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to rosiglitazone, glibenclamide, any other sulfonylureas, metformin, any other biguanides, or any other inactive ingredients present along with these medicines.

Diabetic ketoacidosis

This medicine is not recommended for use in patients with diabetic ketoacidosis due to the increased risk of worsening of the patient's condition.

Type I Diabetes mellitus

This medicine is not recommended for use in patients with type I diabetes mellitus since it is not effective in treating this condition.

Bosentan

This medicine is not recommended for use in patients taking Bosentan since the risk of severe side effects is extremely high.

Severe kidney impairment

This medicine is not recommended for use in patients with a severe impairment of kidney function due to the increased risk of serious adverse effects.

Metabolic Acidosis

This medicine is not recommended for use in patients with metabolic acidosis since it may worsen the patient's condition.

Active liver disease

This medicine is not recommended for use in patients with an active liver disease or an ALT value 2.5 times the upper limit of normal due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Hypoglycemia

This medicine may cause hypoglycemia in some patients. This risk is especially higher in patients suffering from kidney diseases, malnourishment, pituitary gland diseases, etc. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments may be required based on the clinical condition. Your doctor may advise you to carry a sugar candy to counteract the effects of low blood sugar levels (hypoglycemia).

Stress

Use of this medicine should be discontinued in patients exposed to stressful conditions such as a fever, trauma, surgeries, or accidents since it may not be effective in controlling blood sugar levels in these conditions. Replacement with a suitable alternative should be considered under your doctor's supervision.

Liver disease

This medicine should be used with caution in patients with a known history of liver diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Kidney disease

This medicine should be used with caution in patients with a known history of kidney disease due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Cardiovascular diseases

This medicine should be used with extreme caution in patients with a known history of cardiovascular diseases due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Close monitoring of heart function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Weight gain

This medicine may cause a mild to moderate weight gain in some patients.

Hemolytic anemia

This medicine may cause hemolytic anemia in some patients. This risk is especially higher in patients suffering from a G6PD deficiency. Replacement with a suitable alternative may be required in such patients based on the clinical condition.

Alcohol use

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects.

Change of medications

You may experience some temporary side effects if there is a change in the current medications used for diabetes mellitus. This overlapping effect is because of the change from one medicine to another. Close monitoring of blood sugar levels is recommended in these cases.

Pediatric use

This medicine is not recommended for use in children and adolescents since the safety and efficacy of use are not clinically established.

Lactic Acidosis

This medicine may cause lactic acidosis, which may be fatal, in some patients. This risk is especially higher in patients suffering from heart diseases, kidney diseases, etc. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition.

Diarrhea

This medicine may cause diarrhea when therapy is initiated. In most cases, diarrhea subsides by itself. Contact your doctor if the problem persists for longer durations. Therapy may need to be discontinued in some cases based on the clinical condition.

Vitamin B12 deficiency

This medicine should be used with extreme caution in patients with vitamin B12 deficiency since it may worsen the patient's condition. Appropriate vitamin B12 supplementation and dose adjustments may be required in some cases.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
Interaction with Medicine

Amlodipine

Atenolol

Clarithromycin

Estradiol

Gatifloxacin

Iodinated Contrast Media

Aloe Vera

Ibuprofen

Disease interactions

Heart Disease

This medicine should be administered with extreme caution in patients suffering from a disease of the heart or blood vessels due to the increased risk of serious adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Diabetic Ketoacidosis

This medicine is not recommended for use in patients suffering from diabetic ketoacidosis since the risk of adverse effects is significantly high. Replacement with a suitable alternative should be considered under your doctor's supervision.

Kidney Disease

This medicine should be administered with extreme caution in patients with a known history of renal impairment due to the increased risk of serious adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Liver Disease

This medicine should be used with extreme caution in patients with a known history of liver impairment due to the increased risk of adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Hypoglycemia

This medicine should be used with extreme caution in patients predisposed to hypoglycemic episodes. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments may be required based on the blood glucose levels.

Hemolytic Anemia/G6PD Deficiency

This medicine is not recommended for use in patients suffering from hemolytic anemia or G6PD deficiency since it may worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Lactic Acidosis

This medicine may cause lactic acidosis in some patients. This risk is especially higher in patients with kidney diseases, heart diseases, or septicemia. Close monitoring of blood glucose levels, kidney function, heart function, and liver function may be required for such patients based on the clinical condition. Report any symptoms such as fatigue, breathing difficulty, increased sleep, nausea, vomiting, diarrhea, irregular heartbeat, etc. to the doctor immediately. Appropriate corrective measures and discontinuation of therapy may be required in some cases based on the clinical condition.

Vitamin B12 deficiency

This medicine should be used with extreme caution in patients with vitamin B12 deficiency since it may worsen the patient's condition. Appropriate vitamin B12 supplementation and dose adjustments may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as prescribed by the doctor. It is advised to take this medicine with meals. Your dose is likely to change over time based on therapeutic response and clinical condition. Regular monitoring of blood sugar levels is recommended during treatment with this medicine. You should always carry a sugar candy with you to counteract unexpected lowering of blood sugar levels. Do not change the dose or duration of use without consulting your doctor. This medicine will show better results if you maintain a strict exercise and diet regimen. Consult the doctor if you experience any undesirable side effects.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Metformin decreases absorption of glucose from the intestines and increases the action of insulin in the body. Glibenclamide works by increasing the release of insulin from the pancreas. Rosiglitazone decreases insulin resistance without causing any strain on the pancreas and also promotes the breakdown of glucose and fats in the body. The combination is thus better effective than monotherapy in lowering the blood glucose levels.
Legal Status

Banned

Unknown

Unknown

Unknown

Classification

Category

Antidiabetic combinations

Schedule

Schedule H

DailyMed - Avandamet - rosiglitazone maleate and metformin hydrochloride tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 20 September 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0789dc6b-db34-44a6-8a5d-fdcc8e4ce8fd

FDA [Internet]. 2017 [cited 20 September 2017]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021178s015lbl.pdf

Metformin | C4H11N5 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 1 March 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/4091#section=Top

[Internet]. Medsafe.govt.nz. 2017 [cited 16 November 2017]. Available from:

http://www.medsafe.govt.nz/profs/Datasheet/d/Daoniltab.pdf

Rosiglitazone: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 29 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a699023.html
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