Trazodone

Description

Trazodone is used to treat depression associated with anxiety and habitual sleeplessness.

Side effects

Major & minor side effects for Trazodone

  • Blurred vision
  • Dizziness
  • Dry mouth
  • Headache
  • Sweating
  • Shortness of breath
  • Abnormal ejaculation
  • Decreased concentration
  • Feeling of illness
  • Fatigue
  • Nausea and Vomiting
  • Constipation

Uses of Trazodone

What is it prescribed for?

  • Depression
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 2 weeks of administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe side effects such as dizziness, drowsiness, difficulty in concentration, impaired judgment, etc.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to trazodone.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Suicidal tendencies

This medicine should be used with caution due to the increased risk of suicidal tendencies. This risk is especially higher in young patients. Patients should be closely monitored for any change in mood or behavior. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Renal and Liver disease

This medicine should be used with caution in patients with a history of renal or liver diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments may be required based on the clinical condition.

Hypotension

This medicine should be used with caution due to the increased risk of hypotension. Patients are advised to get up slowly from a sitting or a lying position to avoid a sudden drop in the blood pressure. Any symptoms such as fainting, dizziness, lightheadedness, etc. should be reported to the doctor on priority. Close monitoring of blood pressure may be required in some cases. Appropriate dose adjustments may be necessary based on the clinical condition.

Hyponatremia

This medicine should be used with caution due to the increased risk of hyponatremia. This risk is especially higher in elderly patients taking diuretics. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Pediatric use

The safety and efficacy of this medicine have not been clinically established in children.

Bleeding

This medicine should be used with extreme caution in patients receiving nonsteroidal anti-inflammatory medicines and aspirin due to the increased risk of excessive bleeding. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Other Medicines

Trazodone may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Drowsiness

Trazodone may cause drowsiness or sleepiness. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery during treatment with this medicine.

Missed Dose

If a dose of Trazodone is missed, take the dose as soon as you remember it. If it is almost time for the next dose, skip the missed dose and take the next dose. Do not double the dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe side effects such as dizziness, drowsiness, difficulty in concentration, impaired judgment, etc.
Interaction with Medicine

Carbamazepine

Fluoxetine

Ritonavir

Monoamine oxidase inhibitors

Gatifloxacin

Disease interactions

Angle Closure Glaucoma

This medicine should be used with caution in patients with glaucoma due to the increased risk of worsening of the patient's condition. Suitable dose adjustments or an alternative medicine should be considered based on the clinical condition.

Seizures

This medicine should be used with caution in patients with a history of seizure disorder due to the increased risk of recurrent seizures. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Cardiovascular disease

This medicine should be used with caution in patients with a history of cardiovascular diseases due to the increased risk of severe side effects. These side effects may include an increased heart rate, arrhythmias, heart block, and tachycardia. Close monitoring of heart function and vital signs is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Mania

This medicine should be used with caution in patients with a history of mania due to the increased risk of worsening of the patient's condition. Close monitoring of the patients for any changes in mood or behavior is recommended. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Trazodone exactly as instructed by the doctor. Do not take larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken after food

To be taken as instructed by doctor

Causes sleepiness

How it works
Trazodone works by increasing the levels of serotonin in the brain, a natural substance which helps in regulating anxiety, mood, and happiness.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Phenylpiperazine antidepressants

Schedule

Schedule H

[Internet]. 2017 [cited 24 August 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/27176

[Internet]. Toxnet.nlm.nih.gov. 2017 [cited 24 August 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2

DailyMed - Trazodone hydrochloride tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 24 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a699724b-7412-479e-9894-4cf6ec454d8b

Trazodone - DrugBank [Internet]. Drugbank.ca. 2017 [cited 24 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB00656

Trazodone: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 24 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a681038.html

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Information on this page was last updated on 7 Sep 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.