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Trazine-S Tablet
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Trazine-S Tablet

Manufactured bySUN PHARMA LABORATORIES LTD
ContainsTrifluoperazine (5 mg) + Trihexyphenidyl (2 mg)
Description
Trazine-S Tablet is a combination medicine which may be used for the treatment of Schizophrenia, Parkinson's disease, Anxiety, and extrapyramidal symptoms caused by other medicines. This medicine is not recommended for use in patients below 18 years of age.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Trazine-S Tablet

  • Fever
  • Dizziness
  • Headache
  • Confusion
  • Sleeplessness
  • Dry mouth
  • Nausea
  • Vomiting
  • Abdominal pain
  • Constipation
  • Loss of appetite
  • Difficulty in passing urine
  • Skin rash

Uses of Trazine-S Tablet

What is it prescribed for?

  • Schizophrenia
  • Anxiety
  • Parkinson's disease
  • Drug-induced Extrapyramidal Symptoms
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 1 hour of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 6 to 12 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during the treatment with this medicine as it may increase the risk of severe side effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to trifluoperazine, trihexyphenidyl, or any other inactive ingredients present in the formulation.

CNS Depression

This medicine is not recommended for use in patients suffering from severe central nervous system depression or coma due to the increased risk of worsening of the patient's condition.

Narrow-angle glaucoma

This medicine is not recommended for use in patients suffering from narrow-angle glaucoma due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Seizures

This medicine should be used with extreme caution in patients suffering from seizure disorder due to the increased risk of recurrent seizures. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Driving or Operating machinery

Use of this medicine may cause symptoms such as dizziness, blurred vision, confusion, drowsiness, etc. in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Dementia

This medicine is not recommended for use in patients suffering from dementia due to the increased risk of serious adverse effects including death. This risk is especially higher in the elderly patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Neuroleptic Malignant Syndrome

This medicine may cause Neuroleptic Malignant Syndrome (NMS) in patients who discontinued the treatment or reduced the daily recommended dose. Any symptoms of fever, muscle rigidity, altered mental status should be informed to the doctor.

Tardive dyskinesia

This medicine is not recommended for use in patients with tardive dyskinesia which is an involuntary movement of the tongue, lips, and face unless the patient has concomitant Parkinson's disease due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition

Infectious Diarrhea

This medicine decreases the elimination of bacteria that cause diarrhea, therefore, not recommended in patients with infectious diarrhea. Inform the doctor if you are having severe diarrhea or received antibiotics before receiving this medicine.

Hypertension

This medicine should be used with caution in patients with hypertension due to the increased risk of high blood pressure. Regular monitoring of blood pressure is necessary while receiving these medicines. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Withdrawal effect

Do not stop taking this medicine without informing the doctor as it may worsen the disease. Gradual dose reduction should be made, and close monitoring of symptoms is necessary.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during the treatment with this medicine as it may increase the risk of severe side effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
Interaction with Medicine

Atenolol

Clobazam

Bupropion

Citalopram

Clozapine

Amiodarone

Bedaquiline

Ceritinib

Disease interactions

Liver Disease

This medicine should be used with extreme caution in patients suffering from liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Neuroleptic Malignant Syndrome (NMS)

This medicine should be used with extreme caution in patients with a history of neuroleptic malignant syndrome due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with extreme caution in patients suffering from kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Seizure disorders

This medicine should be used with extreme caution in patients suffering from seizure disorder due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Tardive Dyskinesia

This medicine should be used with extreme caution in patients with a history of Tardive Dyskinesia due to the increased risk of recurrent symptoms. This risk is especially higher in elderly female patients. Report any symptoms such as uncontrolled movements of the tongue, mouth, lips, jaw, hands, feet, etc. to your doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Urinary tract obstruction

This medicine is not recommended for use in patients with urinary tract obstruction diseases as it may worsen the condition. Inform the doctor if you are suffering from any urinary tract obstruction diseases, an alternative treatment option should be considered based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as prescribed by your doctor. Follow all the labeled instructions while taking this medicine. Ensure that the right quantity of medicine is consumed for the prescribed duration only. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Trifluoperazine and trihexyphenidyl work by inhibiting the release of certain chemical substances in the brain which are responsible for causing the symptoms of schizophrenia and Parkinson's disease.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Phenothiazine antipsychotics, Anticholinergic antiparkinson agents

Schedule

Schedule H

Trifluoperazine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 14 August 2018]. Available from:

https://www.drugbank.ca/drugs/DB00831

Trihexyphenidyl - DrugBank [Internet]. Drugbank.ca. 2018 [cited 14 August 2018]. Available from:

https://www.drugbank.ca/drugs/DB00376
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Information on this page was last updated on 1 Apr 2019

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.