Trastuzumab

Description

Trastuzumab is used for the treatment of a certain type of cancer of the breast and the stomach that has spread to different parts of the body. It is also used to prevent the relapse of certain cancers. It is either used alone or in a combination with other anti-cancer medications.

Side effects

Major & minor side effects for Trastuzumab

  • Fever
  • Headache
  • Nausea and Vomiting
  • Tiredness and weakness
  • Shortness of breath
  • Diarrhea
  • Reduction in blood cell count
  • Infections
  • Muscle and joint pain
  • Increased cough
  • Swelling of mucous membranes
  • Swelling of the face, lips, or tongue
  • Change in taste
  • Sleep disturbances
  • Stomach pain
  • Heartburn and indigestion
  • Depression
  • Unusual bleeding or bruising
  • Pale skin

Uses of Trastuzumab

What is it prescribed for?

  • Adjuvant breast cancer
  • Metastatic breast cancer
  • Metastatic gastric cancer
Read More
Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the condition and potential risks and benefits associated with use.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to trastuzumab or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the condition and potential risks and benefits associated with use.

Breast-feeding

This medicine is not recommended for use in breastfeeding women. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings

Cardiovascular disorders

Usage of this medicine may increase the risk of heart-related complications. Caution is advised while initiating the therapy in patients with any active heart condition. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Infusion reactions

Usage of this medicine may cause symptoms like fever, chills, nausea, vomiting, dizziness, dyspnea, fall in blood pressure, etc. in some patients. Your doctor may decrease the rate of infusion or discontinue the therapy in such cases and symptomatic treatment will be initiated.

Blood cell counts

Usage of this medicine may alter the levels of blood cell components. Hence, caution is advised while initiating the therapy with this medicine in patients with a pre-existing blood cell disorder. Regular monitoring of blood cell components is advised while this medicine is being administered. An alternative treatment option may be necessary in some cases based on the clinical condition.

Lung diseases

Usage of this medicine may worsen the symptoms of a pre-existing chronic lung disorder. Hence, it should be used with caution in such patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

HER2 testing

It is recommended to test the overexpression of human epidermal growth factor receptor (HER2) using appropriate laboratory methods before the administration of this medicine is initiated.

Women of childbearing potential

Usage of this medicine during pregnancy or within 7 months prior to the conception may increase the risk of fetal harm. Hence, appropriate and adequate contraception is advised for women of childbearing potential during the treatment and for 7 months following the last dose of this medicine.

Driving or Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Tumor lysis syndrome

Usage of this medicine may increase the risk of tumor lysis syndrome, especially in patients with bulky metastases. Frequent clinical monitoring is required while receiving this medicine. An alternative treatment may be necessary in some cases based on the clinical condition.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low. If you miss a scheduled appointment for a dose of this medicine, contact your doctor immediately for further instructions.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Leflunomide

Live vaccines

Etanercept

Doxorubicin

Ganciclovir

Adalimumab

Paclitaxel

Warfarin

Baricitinib

Disease interactions

Pulmonary toxicity

This medicine is not recommended for use in patients who are diagnosed with pneumonitis or interstitial lung disease due to the increased risk of worsening of the patient's condition. Report to your doctor if you are having any pulmonary disorders before receiving this medicine. Usage of this medicine may increase the risk of pulmonary toxicity. An alternative treatment option may be necessary in some cases based on the clinical condition.

Cardiovascular disease

This medicine should be used with caution in patients suffering from cardiovascular diseases due to the increased risk of worsening of the patient’s condition. Regular monitoring of heart function and vital signs may be necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Peripheral Neuropathy

This medicine should be used with caution in patients with peripheral neuropathy due to the increased risk of worsening of the patient’s condition. Your doctor may discontinue your therapy if you are diagnosed with grade III or grade IV neuropathy until it is resolved. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition.

Thrombocytopenia

This medicine should be used with caution in patients with decreased platelet counts due to the increased risk of worsening of the patient’s condition. Regular monitoring of platelet count is necessary prior to each dose of this medicine. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. The dose quantity and frequency of administration is very specific and should be adhered to. Certain laboratory tests may be needed before, during, and after the treatment with this medicine. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by stopping the growth of cancer cells in the body.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

HER2 inhibitors

Schedule

Schedule G

[Internet]. Accessdata.fda.gov. 2018 [cited 20 August 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/103792s5250lbl.pdf

DailyMed - Trastuzumab injection, powder, lyophilized, for solution [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 20 August 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=492dbdb2-077e-4064-bff3-372d6af0a7a2

[Internet]. Herceptin.com. 2018 [cited 20 August 2018]. Available from:

https://www.herceptin.com/

How will this medicine affect me?

Consult top doctors online and get an answer now
Chat now

Looking for a doctor?

Book an appointment with the top doctors near you
Book now
Something doesn’t feel right?
Report an error

Information on this page was last updated on 26 Dec 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.