Trafix MF (250/500 mg) Tablet
Manufactured byI-Med Healthcare Ltd.
ContainsMefenamic acid (250 mg) + Tranexamic Acid (500 mg)
Description
Trafix MF (250/500 mg) Tablet is a combination medicine used in the treatment of heavy menstrual bleeding and acute pain that occurs with menstrual disorders.
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Side effects
Major & minor side effects for Trafix MF (250/500 mg) Tablet
- Diarrhea
- Bloating
- Headache
- Dizziness
- Ringing or buzzing in the ears
- Blurred vision
- Weight gain
- Shortness of breath
- Swelling of face, lips, eyelids, tongue, hands and feet
- Peeling and blistering of skin
- Fast heartbeat
- Unusual bleeding or bruising
- Yellow colored eyes or skin
- Difficult or painful urination
- Bloody and Cloudy urine
- Excessive tiredness
- Sinusitis like symptoms
- Back pain
- Anemia
Uses of Trafix MF (250/500 mg) Tablet
What is it prescribed for?
- Primary Dysmenorrhea
- Menorrhagia
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Concerns
Commonly asked questions
- Onset of actionThe effect of this medicine can be observed within 20 minutes of administration of the dose.
- Duration of effectThe effect of this medicine lasts for an average duration of 6 hours.
- Safe with alcohol?Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, drowsiness, confusion, difficulty in concentrating, a very low blood pressure, severe gastrointestinal bleeding, etc.
- Is it habit forming?No habit-forming tendencies were reported.
- Usage in pregnancy?This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on the clinical condition.
- Usage while breast-feeding?This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on the clinical condition.
Allergy
This medicine is not recommended for use in patients with a known allergy to mefenamic acid, any other NSAIDs, tranexamic acid, or any other ingredients present along with these medicines.
Other allergic conditions
This medicine is not recommended for use in patients with allergic conditions such as asthma or urticaria since it may worsen the patient's condition.
Coronary Artery Bypass Surgery (CABG)
This medicine is not recommended for use before or after a CABG (coronary artery bypass graft) procedure since it may worsen the patient's condition.
Acquired defective color vision
This medicine is not recommended for use in patients with a defective color vision since this condition hinders one endpoint of toxicity determination for the medicine.
Subarachnoid hemorrhage
This medicine is not recommended for use in patients with a subarachnoid hemorrhage due to the increased risk of worsening of the patient's condition.
Obstructive blood clotting disorder
This medicine is not recommended for use in patients having clotting disorders or patients predisposed to clotting disorders since it may worsen the patient's condition.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on the clinical condition.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on the clinical condition.
General warnings
Cardiovascular effects
Use of this medicine for a long duration may cause fluid retention and heart failure. This risk is especially higher in patients with a history of cardiovascular diseases. Appropriate corrective measures, frequent clinical monitoring, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.
Asthma
This medicine is not recommended for use in patients with a known history of aspirin or NSAID-sensitive asthma. Replacement with a suitable alternative should be done under your doctor's supervision.
Peptic ulcer
This medicine should be used with extreme caution in patients suffering from peptic ulcer disease due to the increased risk of severe gastrointestinal bleeding. Report any unusual bleeding or bruising to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Allergic skin reaction
This medicine may cause fatal skin allergies without any warnings which may require immediate medical attention. Signs and symptoms like rashes, hives, fever, or other allergic symptoms should be reported to the doctor without any delay. Appropriate corrective measures or replacement with a suitable alternative may be required based on the clinical condition.
Use of hormonal contraceptives
This medicine is not recommended for use in women who are using hormonal contraceptives (pills, patches, vaginal rings, or injections) due to the increased risk of serious adverse effects.
Clotting disorders
This medicine is not recommended for use in patients having clotting disorders or patients predisposed to clotting disorders since it may worsen the patient's condition.
Ophthalmic disorders
This medicine is not recommended for use in patients with a history of any disease where the blood vessels of the eye are obstructed due to clot formation since it may worsen the patient's condition.
Use in pediatrics
This medicine is not recommended for use in children less than 14 years of age.
Subarachnoid hemorrhage
This medicine is not recommended for use in patients with a subarachnoid hemorrhage since it may worsen the patient's condition.
Missed Dose
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
N/A
Instructions
Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, drowsiness, confusion, difficulty in concentrating, a very low blood pressure, severe gastrointestinal bleeding, etc.
Interaction with Medicine
Glimepiride
Methotrexate
Propranolol
Ramipril
Tacrolimus
Tamoxifen
Warfarin
Ethinyl Estradiol
Furosemide
Aspirin
Ketorolac
Tretinoin
Factor IX complex
Immune globulin (intravenous)
Spironolactone
Disease interactions
Asthma
This medicine is not recommended for use in patients with a known history of aspirin or NSAID-sensitive asthma. Replacement with a suitable alternative should be done under your doctor's supervision.
Fluid Retention and edema
This medicine may cause fluid retention and edema in some patients. Close monitoring of blood pressure, electrolyte levels, and heart function may be required based on the clinical condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases.
Gastro-Intestinal toxicity
This medicine may cause damage to the stomach, intestines, liver, etc., especially on prolonged use. Report any symptoms such as chronic indigestion, blood in stool or vomit, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Skin rash and peeling
This medicine may cause fatal skin allergies without any warnings in some patients. Signs and symptoms such as rashes, hives, fever, or other allergic symptoms should be reported to the doctor without any delay. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.
Impaired kidney function
This medicine should be used with extreme caution in patients with a history of kidney diseases or active kidney diseases. Appropriate dose adjustments, close monitoring of renal function, or replacement with a suitable alternative may be necessary based on the clinical condition.
Impaired liver function
This medicine should be used with caution in patients with a history of liver diseases or active liver diseases. Appropriate dose adjustments, close monitoring of liver function, or replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Diazo test for urinary bile
You may get a false-positive result for this test while taking this medicine. It is advised that you inform the doctor and lab technician about all your current medicines including herbs and supplements before undergoing any lab tests.
Take this medicine as instructed by the doctor. Do not take in larger or smaller quantities than recommended. The dosage and the duration of use of this medicine should be kept as low as possible. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous
How it works
Mefenamic acid provides pain relief by blocking the production of certain chemicals responsible for causing pain and swelling. Tranexamic acid stabilizes the blood clot by inhibiting certain enzymes which break down the clot during a bleeding episode.
Legal Status
Classification
Category
Analgesic combinations, Miscellaneous coagulation modifiers
Schedule
Schedule H
DailyMed - Tranexamic acid injection, solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 11 April 2017]. Available from:
Tranexamic Acid: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 11 April 2017]. Available from:
DailyMed - Mefenamic acid capsule [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 30 May 2017]. Available from:
Mefenamic Acid: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 30 May 2017]. Available from:
Tranexamic Acid + Mefenamic Acid Tablets [Internet]. Neisslabs.com. 2017 [cited 19 September 2017]. Available from:
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Information on this page was last updated on 2 Oct 2017
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