Torisel 25 mg Injection

Manufactured byPfizer Ltd.
ContainsTemsirolimus
Description

Torisel 25 mg Injection is an anticancer medicine which is used in the treatment of a type of kidney cancer. This medicine is not recommended for use in children and adolescents.

Substitutes

List of substitutes for Torisel 25 mg Injection

Genxtor 25 mg Injection
Biocon Ltd.

Side effects

Major & minor side effects for Torisel 25 mg Injection

  • Hypersensitivity
  • Infections
  • Anemia
  • Increased cholesterol and triglycerides
  • Increase in blood glucose level
  • Increase in liver enzyme levels
  • Low potassium
  • Nosebleed
  • Trouble sleeping
  • Acne
  • Diarrhea
  • Nausea and vomiting
  • Loss of appetite

Uses of Torisel 25 mg Injection

What is it prescribed for?

  • Renal cell carcinoma
Read More
Concerns

Commonly asked questions

  • Onset of action
    The time required for this medicine to show its effect is not clinically established.
  • Duration of effect
    This medicine remains active in the body for an average duration of 1 week.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to temsirolimus or any other components present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
General warnings

Hygeine

This medicine may increase the risk of infections. Appropriate safety measures like washing your hands frequently and not coming into contact with people who are sick should be taken to keep away from the infections.

Gastrointestinal perforation

Torisel 25 mg Injection may cause gastrointestinal perforation. It is recommended that any symptoms such as worsening abdominal pain or blood in the stools should be reported to the doctor immediately.

Laboratory monitoring

Laboratory monitoring of patients receiving Torisel 25 mg Injection has to be done frequently and upon doctor's instructions due to an increased risk of bleeding disorders.

Cataract

Combined use of Torisel 25 mg Injection and Interferon alpha may increase the risk of cataracts. Patients should be monitored closely by an ophthalmologist before, during, and after taking this combination to ensure that a cataract has not developed.

Elevated Glucose levels

This medicine may significantly increase blood glucose levels. This risk is especially higher in patients with diabetes. Report any symptoms such as excessive thirst or frequency of urination to the doctor immediately. Close monitoring of blood glucose levels is necessary during treatment with this medicine. Appropriate dose adjustments in either Torisel 25 mg Injection or antidiabetic medicines may be necessary based on the clinical condition of the patient.

Elevated cholesterol and triglycerides levels

Torisel 25 mg Injection may cause significant elevations in blood cholesterol and triglyceride levels. This risk is especially higher in patients with lipid metabolism disorders. Report any unusual symptoms to the doctor immediately. Close monitoring of cholesterol and triglycerides levels is necessary during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.

Missed Dose

If an appointment to take a dose of Torisel 25 mg Injection is missed, call the doctor immediately and take the dose as instructed by the doctor.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Carbamazepine

Leflunomide

Azole antifungal agents

Live vaccines

Fosphenytoin

Anticoagulants

Antibiotics

Disease interactions

Lung dysfunction

Caution is advised while using this medicine in patients with lung diseases due to the increased risk of serious adverse effects. It is advised that patients should undergo baseline radiographic examination of the lung before initiation of this medicine. Close monitoring of lung function is recommended during treatment with this medicine. Any respiratory symptoms should be reported to the doctor on priority. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Renal Diseases

Caution is advised while using this medicine alone or along with any medicine that may increase the risk of kidney dysfunction. Close monitoring of kidney function is necessary during treatment with this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Liver disease

Caution is advised while using this medicine in patients with liver diseases due to the increased risk of severe side effects. Close monitoring of liver function is recommended during treatment with this medicine. Appropriate dose adjustments should be done based on the levels of AST and bilirubin.

Infections

Caution is advised while using this medicine in patients who are at a risk of chronic or severe infections since this medicine further increases the risk of infections. Any signs of infections such as swelling, fever, redness, warmth, sore throat, etc. should be reported to the doctor promptly. If any signs of a new infection occur, it is advised to interrupt the therapy and take appropriate corrective measures.

Wound complications

This medicine may cause delayed wound healing and wound related complications which may require surgery.
Food interactions
It is recommended not to take grapefruit or grapefruit juice during treatment with this medicine due to the increased risk of serious adverse effects.
Lab interactions
Information not available.
Take Torisel 25 mg Injection exactly as advised by your doctor. Do not take in larger amounts than advised or share this medicine with others. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Torisel 25 mg Injection slows down the growth of the cancer cells and prevents them from multiplying.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antineoplastics, Kinase inhibitors

Schedule

Schedule H

DailyMed - TORISEL- temsirolimus [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 7 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=95b7dc92-2180-42f1-8699-3c28f609e674&audience=consumer

Temsirolimus: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 7 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a607071.html

[Internet]. 2017 [cited 7 August 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/21260

Temsirolimus [Internet]. Snomedbrowser.com. 2017 [cited 7 August 2017]. Available from:

http://www.snomedbrowser.com/Codes/Details/427153004

[Internet]. 2017 [cited 7 August 2017]. Available from:

https://gp2u.com.au/static/pdf/T/TORISEL-CMI.pdf

TOXNET [Internet]. Toxnet.nlm.nih.gov. 2017 [cited 7 August 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~jvfUf9:4
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