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Tonact EZ 20 Tablet
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Tonact EZ 20 Tablet

Manufactured byLUPIN LTD
ContainsAtorvastatin (20 mg) + Ezetimibe (10 mg)
Description
Tonact EZ 20 Tablet is a combination medicine used for the treatment of primary hypercholesterolemia, a condition characterized by high levels of cholesterol in the blood. Patients are advised to maintain a strict exercise and diet regimen along with this medicine for the best possible effect. This medicine is not recommended for use in patients less than 18 years of age.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Tonact EZ 20 Tablet

  • Cough
  • Diarrhea
  • Impaired liver function
  • Joint pain
  • Muscle pain
  • Runny Nose
  • Difficulty in breathing
  • Difficulty in falling or staying asleep
  • Headache
  • Dizziness
  • Sore throat
  • Sneezing
  • Itching
  • Loss of appetite
  • Fever

Uses of Tonact EZ 20 Tablet

What is it prescribed for?

  • Primary Hypercholesterolemia
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women. Your doctor may prescribe a safer alternative based on the clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women. Your doctor may prescribe a safer alternative based on the clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to atorvastatin, ezetimibe, or any other inactive ingredients present along with these medicines.

Active liver disease

This medicine is not recommended for use in patients with active liver diseases or any persistent elevations of transaminases due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women. Your doctor may prescribe a safer alternative based on the clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women. Your doctor may prescribe a safer alternative based on the clinical condition.
General warnings

Cognitive impairment

This medicine may cause forgetfulness, memory loss, and confusion in some patients. These symptoms usually disappear gradually once the use of the medicine is discontinued.

Increase in blood sugar levels

This medicine may cause an increase in the blood glucose levels along with an increase in the Glycated Hemoglobin levels. This risk is especially higher in patients with a history of diabetes mellitus. Close monitoring of blood glucose levels, appropriate corrective measures, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Heavy alcohol consumption

This medicine may cause liver and kidney related problems if you consume alcohol very frequently in large quantities during treatment with this medicine.

Coumarin Anticoagulants

This medicine should be used with extreme caution in patients receiving coumarin anticoagulants such as warfarin due to the increased risk of excessive bleeding. Close monitoring of International Normalized Ratio (INR) is recommended for such patients. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Pediatric use

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Rhabdomyolysis

This medicine may cause rhabdomyolysis, a serious condition characterized by weakness and tenderness of muscles. Any symptoms of muscle pain, tenderness, or weakness should be reported to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition of the patient.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clarithromycin

Erythromycin

Azithromycin

Atazanavir

Cyclosporine

Cholestyramine

Fenofibrate

Fluvoxamine

Disease interactions

Liver Disease

This medicine should be used with extreme caution in patients with a known history of liver diseases due to the increased risk of serious adverse effects. It is not recommended for use in patients with active liver diseases or persistent elevation of transaminases levels. Close monitoring of liver function tests or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Cognitive Impairment

This medicine should be used with caution in patients with a history of cognitive impairment since it may worsen the patient's condition. Close monitoring of the patient for any changes in mood or behavior is recommended. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Diabetes

This medicine should be used with caution in patients with a known history of diabetes due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is recommended for these patients. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with this medicine due to the increased risk of severe adverse effects. These side effects may include muscle pain and weakness, fever, chills, swelling of joints, skin rash, nausea, vomiting, etc.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine as advised by your doctor. It can be taken with or without food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Atorvastatin acts on an enzyme responsible for the production of cholesterol in the blood and reduces the levels of cholesterol in the blood. Ezetimibe works by reducing or stopping the absorption of cholesterol through the small intestine. Their combination is thus better effective than monotherapy for the treatment of primary hypercholesterolemia.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antihyperlipidemic combinations

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2018 [cited 12 March 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/200153s003lbl.pdf

[Internet]. 2017 [cited 23 February 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.2498.latest.pdf

[Internet]. 2017 [cited 23 August 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/12091

[Internet]. Tga.gov.au. 2018 [cited 12 March 2018]. Available from:

https://www.tga.gov.au/sites/default/files/auspar-ezetimbe-atorvastatin-130528-pi.pdf
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Information on this page was last updated on 10 Jul 2018

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