Tolvaptan

Description

Tolvaptan is used for the treatment of decreased sodium levels (hyponatremia) and autosomal dominant polycystic kidney disease (ADPKD), a genetic disorder characterized by the growth of numerous cysts in the kidneys. The first few doses of this medicine need to be taken in the hospital, under the supervision of a qualified healthcare professional. It is advised that you do not stop the use of this medicine without consulting your doctor.

Side effects

Major & minor side effects for Tolvaptan

  • Abdominal pain or stomach pain
  • Dry mouth
  • Frequent urination
  • Increased thirst
  • Sweating
  • Dehydration
  • Increased sodium level
  • Dizziness
  • Dry skin

Uses of Tolvaptan

What is it prescribed for?

  • Hyponatremia
  • Autosomal Dominant Polycystic Kidney Disease (ADPKD)
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the medicine or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to tolvaptan or any other inactive ingredients present along with it.

Unable to sense or respond to thirst

This medicine is not recommended for use in patients unable to sense or respond to thirst due to the increased risk of severe dehydration.

Anuria

This medicine is not recommended for use in patients suffering from anuria (inability to produce urine) due to the increased risk of worsening of the patient's condition.

Volume depletion

This medicine is not recommended for use in patients suffering from volume depletion since it may worsen the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the medicine or to discontinue breastfeeding based on your clinical condition.
General warnings

Liver Damage

This medicine should be used with caution due to the increased risk of severe liver injuries. This risk is especially higher if the treatment is continued for more than 30 days. Close monitoring of liver function is recommended during treatment with this medicine. Report any signs and symptoms of liver injuries such as yellowing of the skin or eyes, tiredness, weakness, loss of appetite, etc. to the doctor immediately and discontinue therapy. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Dehydration

This medicine should be used with caution due to the increased risk of severe dehydration. It is advised that you consume an adequate amount of water to prevent dehydration during treatment with this medicine. Close monitoring of clinical condition and electrolyte status, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition of the patient.

Use in Children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Since this medicine is usually taken in a hospital, under medical supervision, the likelihood of a missed dose is very low. If you are taking this medicine in your home, take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical intervention or contact your doctor immediately if you suspect an overdose of this medicine. Symptoms of an overdose may include excessive dehydration, increased thirst, frequent urination, etc.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Phenobarbital

ACE inhibitors

Ketoconazole

Disease interactions

Impaired liver function

This medicine is not recommended for use in patients suffering from liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is recommended during treatment with this medicine. Report any symptoms such as tiredness, loss of appetite, right upper abdominal pain, dark-colored urine, yellowing of eyes or skin, etc. to the doctor immediately and discontinue the treatment immediately. Replacement with a suitable alternative should be considered based on the clinical condition of the patient.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with this medicine due to the increased risk of serious adverse effects such as difficulty swallowing or speaking, muscle weakness, confusion, mood changes, seizures, etc.
Lab interactions
Information not available.
At the beginning of therapy and any time you restart therapy with this medicine, the first few doses will be given in a hospital with close monitoring of your clinical condition. If you are allowed to take this medicine at home, follow all the instructions given by your doctor closely. Report any unusual symptoms such as loss of appetite, tiredness, yellowing of the skin or eyes, etc. to the doctor immediately. You are advised to drink an adequate amount of water/fluids to prevent dehydration during treatment with this medicine.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine increases the amount of water in the urine as well as blocks the passage of sodium through the urine, thus increasing the sodium level in the body.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Vasopressin antagonists

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2018 [cited 27 July 2018]. Available from:

https://www.medicines.org.uk/emc/product/6849/smpc#POSOLOGY

[Internet]. Ebs.tga.gov.au. 2018 [cited 27 July 2018]. Available from:

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2017-PI-01500-1

[Internet]. Medicines.org.uk. 2018 [cited 27 July 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.6635.pdf

[Internet]. Ouh.nhs.uk. 2018 [cited 27 July 2018]. Available from:

https://www.ouh.nhs.uk/patient-guide/leaflets/files/14453Ptolvaptan.pdf

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Information on this page was last updated on 1 Aug 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.