Tolbutamide

Description

Tolbutamide is an antidiabetic medicine used alone or in combination with other medicines to treat type 2 diabetes. Patients are advised to follow a strict diet and exercise regimen along with this medicine to get the best possible effect.

Side effects

Major & minor side effects for Tolbutamide

  • Hypoglycemia
  • Dizziness
  • Headache
  • Lightheadedness
  • Lethargy
  • Dark colored urine
  • Decreased urine output
  • Muscle pain
  • Confusion
  • Swelling of face, ankles and hands
  • Indigestion
  • Scaly skin
  • Weight loss
  • Itching
  • Irregular heartbeat
  • Nausea and Vomiting

Uses of Tolbutamide

What is it prescribed for?

  • Type 2 diabetes
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is 1 hour.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is 6 to 24 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. If the medicine is used, close monitoring of the infant for any undesired side effects is necessary.

Allergy

This medicine is not recommended for use in patients with a known allergy to tolbutamide.

Type I Diabetes mellitus

This medicine is not recommended for use in patients with type 1 diabetes mellitus.

Diabetic ketoacidosis

This medicine is not recommended for use in patients with diabetic ketoacidosis due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. Discuss all the risks and benefits with your doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. If the medicine is used, close monitoring of the infant for any undesired side effects is necessary.
General warnings

Hemolytic anemia

This medicine should be used with extreme caution in patients with glucose 6-phosphate dehydrogenase deficiency due to the increased risk of hemolytic anemia. Replacement with a suitable alternative should be considered based on the clinical condition of the patient.

Hyponatremia

This medicine may cause hyponatremia in patients who are on other medicines or have medical conditions known to cause hyponatremia. Close monitoring of blood sodium levels is recommended for such patients. Appropriate dose adjustments may be necessary based on the clinical condition.

Missed Dose

If a dose of Tolbutamide is missed, take the dose as soon as you remember it. If it is almost time for the next dose, skip the missed dose. Do not double the dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Miconazole

Beta blockers

Probenecid

Gatifloxacin

Disease interactions

Cardiovascular disease

This medicine should be used with caution in patients with cardiovascular diseases since it may increase the risk of cardiovascular mortality. Close monitoring of heart function is recommended for such patients. An alternative treatment option should be considered based on the clinical condition.

Diabetic Ketoacidosis

This medicine is not recommended for use in patients with diabetic ketoacidosis due to the increased risk of worsening of the patient's condition. An alternative treatment option should be considered based on the clinical condition.

Renal Diseases

This medicine should be used with caution in patients with renal diseases due to the increased risk of severe side effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Hypoglycemia

This medicine should be used with extreme caution in patients who are susceptible to hypoglycemia and patients on other anti-diabetic medications or beta-blockers due to the increased risk of very low blood sugars. Close monitoring of blood glucose levels may be necessary based on the clinical condition of the patient. Appropriate dose adjustments or replacement with a suitable alternative should be considered for such patients.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe side effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Tolbutamide exactly as instructed by the doctor. Do not take larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor. You should always carry a sugar candy with you to overcome unexpected lowering of blood sugar levels.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Tolbutamide works by increasing the levels of insulin. This, in turn, lowers the blood glucose levels.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Sulfonylureas

Schedule

N/A

DailyMed - TOLBUTAMIDE- tolbutamide tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 19 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3995eed8-39ec-ce5e-8cc2-062f93445c8d

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 19 August 2017]. Available from:

http://www.tga.gov.au/prescribing-medicines-pregnancy-database

Tolbutamide - DrugBank [Internet]. Drugbank.ca. 2017 [cited 19 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB01124

Tolbutamide: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 19 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682481.html

TOXNET [Internet]. Toxnet.nlm.nih.gov. 2017 [cited 19 August 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~zV5OED:6

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Information on this page was last updated on 4 Sep 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.