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Tobamist 300 mg Respules

Manufactured byCipla Ltd.
ContainsTobramycin
Description

Tobamist 300 mg Respules is an antibiotic used for the management of cystic fibrosis (a genetic disorder that affects mostly the lungs but also causes severe damage to the digestive systems) in patients with pneumonia (Pseudomonas aeruginosa infections). It is recommended for use in adults and children aged 6 years and above.

Side effects

Major & minor side effects for Tobamist 300 mg Respules

  • Hearing loss
  • Ringing or buzzing in the ears
  • Headache
  • Nosebleed
  • Difficulty in breathing
  • Hoarseness of voice
  • Unusual tiredness and weakness
  • Fever

Uses of Tobamist 300 mg Respules

What is it prescribed for?

  • Pneumonia with cystic fibrosis
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to tobramycin, any other aminoglycosides, or any other inactive ingredients present along with the formulation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
General warnings

Drug resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of developing bacteria that are drug-resistant.

Hearing loss

This medicine may cause hearing loss and should be used with extreme caution in patients with auditory impairment. Close monitoring of hearing function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Myasthenia gravis

This medicine should be used with extreme caution in patients with a history of myasthenia gravis due to the increased risk of worsening of the patient's condition. Any unusual symptoms should be reported to the doctor on priority. Close monitoring of the clinical condition, appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Use in children

This medicine is not recommended for use in patients less than 6 years of age since the safety and efficacy of use are not clinically established.

Bronchospasm

This medicine may cause bronchospasm (constriction of the bronchial muscles) in some patients upon therapy. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Missed Dose

If a dose is missed, take the dose as soon as you remember it. If it is almost the time for the next dose, skip the missed dose and take the next dose. Do not double the dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Omeprazole

Diuretics

Neuromuscular blockers

Colistin

Disease interactions

Neuromuscular Blockade

This medicine should be used with extreme caution in patients with neuromuscular disorders such as Parkinson's syndrome or myasthenia gravis since it may worsen the condition of the patient. Patients should be closely monitored for any signs of respiratory paralysis, and if any signs occur, the therapy should be discontinued and appropriate corrective measures should be taken immediately.

Impaired kidney function

This medicine should be used with extreme caution in patients with kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is recommended during treatment with this medicine. Any unusual symptoms should be reported to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Administer this medicine exactly as prescribed by your doctor. Follow all the instructions given in the information leaflet/package insert. Do not use in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine kills the bacteria by blocking the production of certain proteins that are required for their growth.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Aminoglycosides, Inhaled anti-infectives

Schedule

Schedule H

Tobamist Solution [Internet]. CiplaMed. 2020 [cited 17 January 2020]. Available from:

https://www.ciplamed.com/content/tobamist-solution

Tobramycin 300 mg/ 5 ml nebuliser solution - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2020 [cited 17 January 2020]. Available from:

https://www.medicines.org.uk/emc/product/2683/smpc

DailyMed - Tobramycin solution [Internet]. Dailymed.nlm.nih.gov. 2020 [cited 17 January 2020]. Available from:

https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c5f65e5b-c851-45da-a0e8-215d9a4e6ad3

[Internet]. Accessdata.fda.gov. 2020 [cited 17 January 2020]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/050753s022lbl.pdf
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Information on this page was last updated on 17 Jan 2020

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