Tirofiban

Description

Tirofiban is used in combination with heparin for decreasing the risks of major and life-threatening events or new episodes of heart attacks in patients suffering from non-ST elevation acute coronary syndrome (NSTE-ACS). Acute coronary syndrome (ACS) is caused by a sudden reduction or blockage of blood flow to the heart, causing chest pain and heart attacks. This medicine is used in patients who are to be managed medically. It is also used for the reduction of life-threatening adverse events in patients undergoing percutaneous transluminal coronary angioplasty (PTCA) or atherectomy.

Side effects

Major & minor side effects for Tirofiban

  • Unusual bleeding or bruising
  • Abdominal or stomach pain
  • Swelling of the hands, ankles, feet, or lower legs
  • Dizziness and fainting
  • Black or tarry stools
  • Headache
  • Fast or irregular heartbeat
  • Bleeding gums
  • Pinpoint red spots on skin
  • Unusual tiredness or weakness
  • Presence of blood in cough

Uses of Tirofiban

What is it prescribed for?

  • Non-ST Elevated Acute Coronary Syndrome (NSTE-ACS)
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed immediately following an intravenous administration.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 4 to 6 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to tirofiban or any other inactive ingredients present along with it.

Bleeding disorder

This medicine is not recommended for use in patients with a history of bleeding disorders due to blood coagulation issues (bleeding diathesis) or active abnormal bleeding within the previous 30 days due to the increased risk of worsening of the patient’s condition.

Severe hypertension

This medicine is not recommended for use in patients suffering from severe hypertension (high blood pressure levels more than 200/110 mm Hg) that is not adequately controlled using appropriate medication due to the increased risk of worsening of the patient’s condition.

Stroke

This medicine is not recommended for use in patients with a history of stroke within the past 30 days or any history of hemorrhagic stroke (an emergency condition where blood vessels rupture within the brain) due to the increased risk of worsening of the patient’s condition.

Major surgery

This medicine is not recommended for use in patients who have undergone major surgery within the preceding 6 weeks due to the increased risk of worsening of the patient’s condition.

Acute pericarditis

This medicine is not recommended for use in patients with acute pericarditis (inflammation of the protective layer surrounding the heart, pericardium) due to the increased risk of worsening of the patient’s condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.
General warnings

Risk of bleeding

Use of this medicine may increase the chances of bleeding, especially in patients with a history of bleeding disorders. It is advised to manage the bleeding without discontinuing the use of this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Other medicines

Tirofiban may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Hypertension

This medicine should be used with caution and monitoring in patients suffering from hypertension (high blood pressure levels). Use is not recommended if the increase in blood pressure level is very high (severe hypertension) and the patient is not receiving appropriate therapy to correct the blood pressure level.

Surgery

This medicine is not recommended for use in patients who have undergone major surgery, injury, trauma, or any other medical emergency within the past 6 weeks. Inform your doctor in advance so that the dose regimen with this medicine can be appropriately adjusted.

Kidney diseases

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Since this medicine is usually administered by a qualified health care professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is usually administered by a qualified health care professional in the clinical/hospital setting, the likelihood of an overdose is very low. However, emergency medical treatment will be instituted by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Enoxaparin

Alteplase

Clopidogrel

Warfarin

Ibuprofen

Abciximab

Disease interactions

Renal impairment

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine prevents the abnormal formation of blood clots and associated adverse events.
Legal Status

Approved

Unknown

Unknown

Approved

Classification

Category

Glycoprotein platelet inhibitors

Schedule

Schedule H

Tirocip Injection [Internet]. CiplaMed. 2019 [cited 23 April 2019]. Available from:

https://ciplamed.com/content/tirocip-injection

Tirofiban - DrugBank [Internet]. Drugbank.ca. 2018 [cited 20 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00775

[Internet]. Accessdata.fda.gov. 2018 [cited 20 September 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/1998/20912lbl.pdf

Tirofiban 50 micrograms/ml Solution for Infusion - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2019 [cited 23 April 2019]. Available from:

https://www.medicines.org.uk/emc/product/7389/smpc

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Information on this page was last updated on 23 Apr 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.