Ticagrelor

Description

Ticagrelor is used along with aspirin to prevent or lower the chances of severe and life-threatening problems associated with the heart and blood vessels in patients who have suffered from a heart attack or severe chest pain (angina). It is also used to prevent the formation of blood clots and associated complications in patients with stents.

Side effects

Major & minor side effects for Ticagrelor

  • Difficult and painful breathing
  • Tightness of chest
  • Blurred vision
  • Confusion
  • Dizziness when getting up suddenly from a sitting position
  • Fainting
  • Fast/irregular heart beat
  • Headache
  • Nervousness
  • Ringing or buzzing in the ears
  • Excessive sweating
  • Unusual tiredness or weakness
  • Bleeding gums
  • Black or Tarry stools
  • Unusual bleeding or bruising
  • Increased menstrual flow
  • Swelling of the face, arms, hands, lower legs, or feet
  • Bleeding from nose

Uses of Ticagrelor

What is it prescribed for?

  • Acute Coronary Syndrome
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 30 minutes of administration of the loading dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to ticagrelor or any other inactive ingredient present in the formulation.

Uncontrolled active bleeding

This medicine is not recommended for use in patients with an active bleeding disorder that may be caused due to complications such as a peptic ulcer or hemorrhages in the head region due to the increased risk of worsening of the patient’s condition.

Intracranial bleeding

This medicine is not recommended for use in patients with a history of bleeding inside the skull since the risk of recurrence of severe bleeding is significantly high.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings

Other medicines

Ticagrelor may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Risk of bleeding

Use of this medicine may increase the chances of bleeding, especially in patients with a history of bleeding disorders. It is advised to manage the bleeding without discontinuing the use of this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Maintenance dose of aspirin

This medicine is normally used in a combination with aspirin. The dose of aspirin in a combination with this medicine should not exceed 100 mg.

Dyspnea

Use of this medicine may cause breathing difficulties, especially in patients with a history of dyspnea. If the symptoms of dyspnea become very severe, then the use of this medicine should be discontinued.

Termination of use

Discontinuing the use of this medicine may increase the risk of heart attack, stroke, and other heart-related complications in some patients. If there is a clinical necessity to stop the use of this medicine, then the uptake of this medicine should be resumed as soon as possible.

Heart rhythm abnormalities

Use of this medicine may cause heart rhythm abnormalities in some patients; the likelihood of occurrence is higher in patients with a history of heart-related complications like sick sinus syndrome, 2nd or 3rd degree AV block, bradycardia related syncope not protected by a pacemaker, etc. Additional monitoring may be required in such cases since the risk of adverse events is significantly high. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Liver diseases

This medicine is not recommended for use in patients with severe impairment of liver function unless absolutely necessary. For mild to moderate impairment of liver function, this medicine may be given with appropriate dose adjustments and frequent monitoring of liver function tests.

Use in Children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Driving or Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Atazanavir

Phenobarbital

Dalteparin

Phenytoin

Carbamazepine

Mifepristone

Clarithromycin

Ketoconazole

Rifampicin

Apixaban

Disease interactions

Liver Disease

This medicine should be used with caution in patients with mild to moderate liver diseases and it is not recommended for use in patients with severe liver diseases unless absolutely necessary. Regular monitoring of the liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Bradyarrhythmia/ AV Block

This medicine should be used with caution and monitoring in patients with a history of sick sinus syndrome, 2nd or 3rd degree AV block, or bradycardia-related syncope not protected by a pacemaker since the risk of developing a severe decrease in heart rate is significantly high. An alternative treatment option may be necessary in some cases based on the clinical condition

Dyspnea

This medicine should be used with caution in patients that experience shortness of breath. Use of this medicine may worsen the episodes of dyspnea in some cases and hence, monitoring is advised. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Renal Diseases

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by the doctor. Do not take it in larger or smaller quantities than recommended. Report any heart-related adverse events to the doctor while this medicine is being taken. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine prevents the platelets from forming clots. It thus helps in the prevention of heart attacks or strokes in susceptible patients.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Platelet aggregation inhibitors

Schedule

Schedule H

[Internet]. Azpicentral.com. 2018 [cited 3 September 2018]. Available from:

https://www.azpicentral.com/brilinta/brilinta.pdf#page=1

[Internet]. Accessdata.fda.gov. 2018 [cited 3 September 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/022433s020lbl.pdf

[Internet]. Brilinta.com. 2018 [cited 3 September 2018]. Available from:

https://www.brilinta.com/

[Internet]. Dailymed.nlm.nih.gov. 2018 [cited 3 September 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

Ticagrelor - DrugBank [Internet]. Drugbank.ca. 2018 [cited 3 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB08816

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Information on this page was last updated on 10 Jan 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.