Ticagrelor
Description
Ticagrelor contains Ticagrelor, which is a blood thinner medicine. It is used along with Aspirin to reduce the risk of heart attack or stroke (damage to your brain resulting from reduced/blocked blood supply) or if you have a history of acute coronary syndrome (conditions resulting from reduced blood flow to your heart). It works by preventing the formation of blood clots.
Ticagrelor may cause common side effects such as bleeding, bruising, dizziness, skin rash and itching, blurred vision, etc. Consult your doctor if these symptoms persist or worsen.
Ticagrelor should be taken exactly as directed by your doctor. Take it at the same time every day to maintain a constant level of this medicine in your body.
Ticagrelor should be avoided if you are allergic to it. Inform your doctor if you have pre-existing kidney or liver problems before beginning treatment with this medicine. Close evaluation with respect to your current medicines is necessary to avoid any undesired side effects. If you are pregnant or breastfeeding, or are planning a pregnancy, consult your doctor before taking this medication.
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Side effects
Major & minor side effects for Ticagrelor
- Increased blood uric acid levels
- Bleeding
- Bruising
- Headache
- Dizziness
- Constipation or diarrhoea
- Indigestion
- Nausea
- Skin rash and itching
- Joint pain and swelling
- Lightheadedness
- Blurred vision
- Nose bleed
Uses of Ticagrelor
What is it prescribed for?
- Acute Coronary Syndrome
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Concerns
Commonly asked questions
- Onset of actionTicagrelor begins to show its effect within 30 minutes after intake.
- Duration of effectTicagrelor remains effective for an approximate duration of two to three days after intake.
- Safe with alcohol?Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is it habit forming?No habit-forming tendencies have been reported with Ticagrelor.
- Usage in pregnancy?Due to a lack of safety and efficacy studies in pregnant women, the risk to your developing foetus due to Ticagrelor is not known. This medicine is not recommended during pregnancy unless necessary. If you are pregnant, consult your doctor.
- Usage while breast-feeding?It is not known whether Ticagrelor passes into breastmilk. Hence this medicine is not recommended during breastfeeding unless necessary. If you are breastfeeding, consult your doctor.
Allergy
Avoid Ticagrelor if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of your face/tongue/throat), severe dizziness, breathing difficulty, etc.
Active bleeding
Ticagrelor is not recommended if you have active bleeding in your stomach/intestines or bleeding due to any other conditions due to the increased risk of worsening your condition.
Intracranial haemorrhage
Intracranial haemorrhage is a condition that causes bleeding within your brain. Ticagrelor is not recommended if you have a history of intracranial haemorrhage due to the increased risk of worsening your condition.
Severe Hepatic impairment
Hepatic impairment is a condition with a loss of liver function. Ticagrelor is metabolized and broken down by the liver and is not recommended if you have severe hepatic impairment due to the increased risk of severe side effects, resulting from the accumulation of this medicine in your body.
Warnings for special population
Pregnancy
Due to a lack of safety and efficacy studies in pregnant women, the risk to your developing foetus due to Ticagrelor is not known. This medicine is not recommended during pregnancy unless necessary. If you are pregnant, consult your doctor.
Breast-feeding
It is not known whether Ticagrelor passes into breastmilk. Hence this medicine is not recommended during breastfeeding unless necessary. If you are breastfeeding, consult your doctor.
General warnings
Other medicines
Ticagrelor may interact with other medicines and cause undesired side effects. Hence, inform your doctor about your current medicines including any herbs and supplements before beginning treatment with this medicine.
Bleeding
Ticagrelor may increase your risk for bleeding and should be used with caution if you had recent surgery, have a history of bleeding in your stomach/intestines, have pre-existing liver problems or if you are on treatment with certain medicines (e.g. non-steroidal anti-inflammatory drugs, oral anticoagulants, fibrinolytics) that may increase your risk of bleeding due to the increased risk of further worsening your condition.
Dyspnoea
Ticagrelor may increase your risk of dyspnoea (shortness of breath). This risk is especially higher if you have a history of asthma/chronic obstructive pulmonary disease (lung problems that cause breathing difficulty) and hence caution is required.
Discontinuation of treatment
Discontinuation of treatment with Ticagrelor may increase your risk of myocardial infarction (heart attack), stroke (damage to your brain resulting from reduced/blocked blood supply), or death. Hence it is recommended to continue using this medicine for the duration prescribed by your doctor.
Heart rhythm abnormalities
Ticagrelor may increase your risk of an irregular heart rhythm. This risk is especially higher if you have pre-existing heart problems and hence caution is required. Your electrocardiogram and electrolyte levels need to be closely monitored for the assessment of heart function.
Use in Children
Ticagrelor is not recommended for use in children below 18 years of age due to a lack of safety and efficacy studies.
Driving or Operating machines
Ticagrelor may cause dizziness and blurred vision. If you experience any symptoms that may affect your mental alertness, do not drive vehicles or operate machines.
Surgery
If you are on treatment with Ticagrelor, inform your doctor before planning surgery. Since Ticagrelor may increase your risk of bleeding, it is recommended to discontinue treatment with this medicine at least 5 days before undergoing surgery. However, your doctor may suggest the appropriate time of withdrawal based on your clinical condition.
Increased creatinine levels
Ticagrelor may cause an increase in creatinine levels. It is recommended to periodically monitor your kidney function after beginning treatment with this medicine.
Hyperuricaemia
Ticagrelor may increase your risk of hyperuricaemia (high blood uric acid levels). This medicine should be used with caution if you have a history of hyperuricaemia or gouty arthritis (a type of arthritis resulting from the accumulation of uric acid crystals in joint spaces).
Thrombotic thrombocytopenic purpura
Ticagrelor may increase your risk of thrombotic thrombocytopenic purpura, a rare condition that causes blood clots to form in small blood vessels throughout your body.
Missed Dose
Try not to skip a dose of Ticagrelor. Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one. Do not double the dose to compensate for a missed one.
Overdose
Do not take more than the prescribed dose. Contact your doctor if you suspect an overdose with Ticagrelor.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Atazanavir
Nefazodone
Dalteparin
Phenytoin
Carbamazepine
Mifepristone
Rifampicin
Apixaban
Phenobarbital
Ketoconazole
Clarithromycin
Disease interactions
Liver Disease
Ticagrelor is metabolized and broken down by the liver and should be used with caution if you have pre-existing liver problems (moderate) due to the increased risk of undesired side effects, resulting from the accumulation of this medicine in your body. Your liver function needs to be closely monitored and dose adjustments may be required based on your clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Ticagrelor with or without food. Do not take more or less than the prescribed dose. Do not stop the use of this medicine without consulting your doctor.
Ticagrelor may increase your risk of bleeding. Inform your doctor if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as red/black tarry stools, coughing up or vomiting blood, etc.
Ticagrelor may cause an increase in your blood uric acid levels. Periodic monitoring of your uric acid levels is recommended.
Do not drive vehicles or operate machines if you experience any symptoms that may affect your alertness after taking Ticagrelor.
Miscelleneous
How it works
Ticagrelor belongs to a class of medicines called antiplatelets. It works by preventing platelets (a type of blood cell) from collecting and forming clots and thereby reduces the risk of a heart attack or a stroke (damage to your brain resulting from reduced/blocked blood supply).
Legal Status
Classification
Category
Platelet aggregation inhibitors
Schedule
Schedule H
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Ebs.tga.gov.au. 2021. TGA eBS - Product and Consumer Medicine Information Licence. [online] Available at: < [Accessed 21 December 2021].
Drugs, H., 2021. Ticagrelor: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 21 December 2021].
nhs.uk. 2021. Ticagrelor: an antiplatelet medicine to prevent blood clots. [online] Available at: < [Accessed 21 December 2021].
Information on this page was last updated on 7 Feb 2022
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