Tibolone
Description
Tibolone is used for the treatment of estrogen deficiency in postmenopausal women. It is also used for the prevention of osteoporosis in postmenopausal women who are at a high risk of features and intolerant for other medicines approved for the prevention of osteoporosis. This medicine is not recommended for use in patients below 18 years of age.
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Side effects
Major & minor side effects for Tibolone
- Abnormal hair growth
- Lower abdominal pain
- Vaginal discharge
- Breast tenderness
- Genital itching
- Vaginal bleeding
- Pelvic pain
- Weight gain
- Acne
- Abdominal discomfort
- Nipple pain
Uses of Tibolone
What is it prescribed for?
- Oestrogen deficiency
- Prevention of osteoporosis
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Concerns
Commonly asked questions
- Onset of actionThe amount of time required for this medicine to show its action is not clinically established.
- Duration of effectThe amount of time for which this medicine remains effective in the body is not clinically established.
- Safe with alcohol?Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is it habit forming?No habit-forming tendencies were reported.
- Usage in pregnancy?This medicine is not recommended for use in pregnant women.
- Usage while breast-feeding?This medicine is not recommended for use in breastfeeding women.
Breast cancer
This medicine is not recommended for use in patients with known, past or suspected breast cancer due to the increased risk of worsening of the patient's condition.
Endometrial cancer
This medicine is not recommended for use in patients with endometrial cancer due to the increased risk of worsening of the patient's condition.
Genital bleeding
This medicine is not recommended for use if you have abnormal genital bleeding which was not diagnosed due to the increased risk of worsening the patient's condition.
Endometrial hyperplasia
This medicine is not recommended for use in patients with endometrial hyperplasia due to the increased risk of worsening the patient's condition.
Venous thromboembolic events
This medicine is not recommended for use in patients with previous or current thromboembolism due to the increased risk of worsening of the patient's condition.
Arterial thromboembolic disease
This medicine is not recommended for use in patients with a known history of arterial thromboembolic diseases such as angina, stroke, myocardial infarction, etc. due to the increased risk of worsening of the patient's condition.
Acute liver disease
This medicine is not recommended for use in patients having an acute liver disease due to the increased risk of worsening of the patient's condition.
Allergy
This medicine is not recommended for use in patients with a known allergy to tibolone or any other inactive ingredients present along with it.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women.
Breast-feeding
This medicine is not recommended for use in breastfeeding women.
General warnings
Breast cancer
This medicine should not be used in patients with previous history or current symptoms of breast cancer due to the increased risk of recurrence of the disease, especially in postmenopausal women. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Limitations of use
This medicine is recommended for use in postmenopausal women only. It is not intended for contraceptive use.
Kidney Disease
This medicine should be used with caution in patients with kidney diseases due to the increased risk of adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Other medicines
Tibolone may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.
Use in Children
This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.
Missed Dose
Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Phenobarbital
Phenytoin
Carbamazepine
Rifampicin
Warfarin
Disease interactions
Disease
Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with or without food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine before completion of the course/without consulting your doctor.
Miscelleneous
How it works
It works by substituting the deficiency of estrogen in the postmenopausal women and alleviates the undesired effects.
Legal Status
Classification
Category
Anabolic steroid
Schedule
Schedule H
Livial 2.5mg tablets - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 6 October 2018]. Available from:
TGA eBS - Product and Consumer Medicine Information Licence [Internet]. Ebs.tga.gov.au. 2018 [cited 6 October 2018]. Available from:
Tibolone 2.5 mg tablets - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 6 October 2018]. Available from:
Information on this page was last updated on 13 Jun 2019
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.