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Thromboparin 5000 IU Injection

Manufactured by: Chandra Bhagat Pharma Pvt. Ltd.
Prescription Required: Yes
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Description

Thromboparin 5000 IU Injection is an anticoagulant used to prevent the formation and growth of blood clots in patients with certain specific medical conditions. It is also used to prevent blood clots that may potentially form during certain medical procedures. It also helps in preventing the formation of blood clots in catheters that are placed in veins for a prolonged period of time.

Side effects

Major & minor side effects for Thromboparin 5000 IU Injection

  • Abdominal and stomach pain
  • Back pain
  • Bleeding gums
  • Easy Bruising and bleeding
  • Severe and continuing headaches
  • Constipation
  • Bloody stool
  • Chest pain and discomfortrare
  • Nausea or Vomitingrare
  • Injection site Thrombophlebitis
  • Skin rash and peelingrare
  • Change in visionrare
  • Puffing or swelling of eyelids
  • Ulcers at the injection siterare
  • Osteoporosissevererare
  • Increased liver enzyme levelssevererare
SEVERE
Contact your doctor immediately if any of these symptoms are experienced on a regular basis.
RARE
Observed in a small fraction of population.
This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Highlights

Commonly asked questions for Thromboparin 5000 IU Injection

Onset of action

The effect of this medicine can be observed immediately after intravenous administration. Upon subcutaneous administration, the effect can be observed within 20-60 minutes.

Duration of effect

The time duration for which this medicine remains effective is subject to vary based on the intended use, dose strength, and route of administration.

Safe with alcohol?

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Is it habit forming?

No habit forming tendencies were reported.

Usage in pregnancy?

This medicine is recommended for use in pregnant women only when absolutely necessary and the potential benefits outweigh the risks involved. Preservative free forms are recommended for administration.

Usage while breast-feeding?

This medicine is recommended for use in breastfeeding women only when absolutely necessary and the potential benefits outweigh the risks involved. Preservative free forms are recommended for administration.

Substitutes

List of substitutes for Thromboparin 5000 IU Injection

Below is the list of medicines, which have the same composition, strength and form as Thromboparin 5000 IU Injection, and hence can be used as its substitute.
Beparine 5000 IU Injection
Biological E. Ltd.
Lofh 5000 IU Injection
Abbott Healthcare Pvt. Ltd.
Neporin 5000 IU Injection
Biocon Ltd.
Prevaclot 5000 IU Injection
Biological E. Ltd.
Thinla 5000 IU Injection
Biocon Ltd.

What is it prescribed for?

Uses of Thromboparin 5000 IU Injection

  • Deep Vein Thrombosis

    This medicine is used for the prevention and treatment of blood clot formation in a deep vein, most commonly in the legs.

  • Thromboembolism in Atrial Fibrillation

    This medicine is used for the treatment and prevention of the formation of obstructive clots (Thromboembolism) in blood vessels, associated with atrial fibrillation.

  • Pulmonary Embolism

    This medicine is used for the treatment and prevention of pulmonary embolism, a condition where one or more arteries in the lungs become blocked by a clot. The blood clot is normally formed elsewhere and migrates to the lung via blood.

  • Disseminated intravascular coagulation

    This medicine is used for the treatment of both short and long-term formation of blood clots in the small blood vessels throughout the body which may cause damage to multiple organs.

  • Venous thromboembolic events

    This medicine is used to treat and prevent the formation of blood clots in veins, which could potentially break loose and migrate to other locations, causing further complications.

  • Prevention of clots during surgeries

    This medicine is used to prevent clot formation during complex surgeries of the heart and the blood vessels. It is also used for the prevention of reocclusion of blood vessels in the heart after correctional surgery is performed.

  • Blood transfusion

    This medicine is used for the prevention of clot formation during the blood transfusion process.

  • Maintenance of patency of implanted intravenous devices

    This medicine is used in small quantities to prevent the formation of blood clots in devices/catheters that are left in the veins for a period of time (maintenance of patency).

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When not to use?

Contraindications of Thromboparin 5000 IU Injection

  • Allergy

    This medicine is not recommended for use in patients with a known allergy to heparin or any other inactive ingredient present along with it.

  • Uncontrolled active bleeding

    This medicine is not recommended for use in patients having uncontrolled active bleeding except when it is associated with Disseminated intravascular coagulation.

  • Inability to perform coagulation tests

    This medicine is not recommended for use in patients who cannot undergo coagulation tests at appropriate intervals. This is generally applicable for patients receiving full dose therapy, not for those on a fixed low-dose therapy.

  • Thrombocytopenia

    This medicine is not recommended for use in patients with a known history of thrombocytopenia associated with the use of heparin.

Dosage

  • Missed Dose

    This medicine is usually administered in a clinical or hospital setup. However, if you are administering it at home and miss a scheduled dose, then call your doctor immediately for further instructions.

  • Overdose

    Seek emergency medical attention in case of an overdose or suspected overdose. Symptoms of an overdose may include nosebleed, unusual bruising and bleeding, and the presence of blood in stool or urine.

Interactions

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

  • Description

    - Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Instructions

    - Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Disease interactions

  • Peptic ulcer disease

    severe
    Use of this medicine is not recommended in patients with an active peptic ulcer disease due to the increased risk of severe internal bleeding and hemorrhage which may be fatal.

  • Active bleeding disorder

    severe
    Use of this medicine is not recommended in patients with an active bleeding disorder due to the increased risk of excessive bleeding which may be fatal. However, this medicine can be used for treating patients diagnosed with disseminated intravascular coagulation.

  • Kidney disease

    severe
    This medicine should be used with extreme caution in patients having a kidney disease or impairment of normal renal function due to the increased risk of excessive bleeding. Appropriate dose adjustments and close monitoring of kidney function are recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition.

  • Thrombocytopenia

    severe
    This medicine should be used with extreme caution in patients with Thrombocytopenia due to the increased risk of worsening of the patient's condition. Appropriate tests including blood platelet counts must be done before starting therapy and at regular intervals during therapy to safely use this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition.

  • Hyperkalemia

    moderate
    This medicine should be used with caution due to the increased risk of hyperkalemia (increased serum potassium levels) which may cause severe side effects such as an irregular heart rhythm, muscle paralysis, etc. This risk is especially higher in elderly patients with heart diseases, kidney diseases, or diabetes mellitus. Appropriate tests must be conducted to determine the potassium levels before and during treatment with this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition.

Food interactions

  • This medicine should be used with caution with fish oil or other food products containing omega-3 polyunsaturated fatty acids due to the increased risk of bleeding. Contact your doctor immediately if you experience any unusual bleeding or bruising, dizziness, weakness, and the presence of blood in sputum/urine/stool. Your doctor/dietitian may suggest appropriate changes in your diet to avoid this interaction.
  • This medicine should be used with caution with ginger/garlic due to the increased risk of bleeding. Contact your doctor immediately if you experience any unusual bleeding or bruising, dizziness, weakness, and the presence of blood in sputum/urine/stool. Your doctor/dietitian may suggest appropriate changes in your diet to avoid this interaction.

Lab interactions

  • Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

General Instructions

Administer Thromboparin 5000 IU Injection exactly as instructed by the doctor. It should not be injected into the muscles. It is advised to administer this medicine under the supervision of a doctor in a clinical setup with regular monitoring of blood clotting time and other related parameters. Your doctor may ask you to undergo certain tests to determine the safety of use of this medicine.

Warnings

Warnings for special population

  • Pregnancy

    - This medicine is recommended for use in pregnant women only when absolutely necessary and the potential benefits outweigh the risks involved. Preservative free forms are recommended for administration.

  • Breast-feeding

    - This medicine is recommended for use in breastfeeding women only when absolutely necessary and the potential benefits outweigh the risks involved. Preservative free forms are recommended for administration.

General warnings

  • Hemorrhage and risk factors

    - Use of this medicine should be initiated only after internal bleeding or hemorrhage and associated risk factors are ruled out. All the underlying causes of bleeding such as peptic ulcer disease, hemophilia, impaired hemostasis, etc. should also be ruled out before the administration of this medicine.

  • Thrombocytopenia

    - Use of this medicine may cause low levels of platelets (thrombocytopenia). It is advised to monitor the blood platelet levels at regular intervals while this medicine is administered. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

  • Use in elderly

    - This medicine should be used with extreme caution in the elderly population since the risk of adverse effects is significantly high. Appropriate dose adjustments and frequent clinical monitoring are advised for such patients to safely use this medicine.

  • Benzyl alcohol as preservative

    - Dosage forms containing benzyl alcohol as a preservative should not be administered to neonates, infants, and pregnant or breastfeeding women. Benzyl alcohol may cause a fatal adverse event known as Gasping syndrome in neonates and infants.

  • Liver/kidney disease

    - This medicine should be used with caution in patients having an impairment of normal liver/kidney function. Appropriate dose adjustments and frequent clinical monitoring are recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition.

  • Hyperkalemia

    - Use of this medicine may cause an increase in blood potassium levels (hyperkalemia) and associated complications. Close monitoring of potassium levels may be necessary based on the clinical condition.

  • Osteoporosis

    - Use of this medicine in high doses for a prolonged duration may cause osteoporosis and associated complications.

  • Other medicines

    - This medicine may interact with many other medicines and may cause severe side effects. Hence, you are advised to report the use of all medicines including herbs and supplements to the doctor before beginning treatment with this medicine.

  • Occurrence of side effects

    - It is possible that you may experience certain side effects after the use of this medicine has been stopped. Report any instances of unusual symptoms to the doctor immediately.

  • Smoking and use of tobacco products

    - Inform the doctor about your smoking habits or use of tobacco in any form before treatment with this medicine is initiated. Use of tobacco products may decrease the effectiveness of this medicine.

  • Injection incompatibility

    - The intravenous form of this medicine should not be mixed with certain diluents and medicines due to incompatibility. Caution should be exercised while picking the diluent and other medicines at the time of administration.

Other details

  • Usage does not depend on food timings
  • To be taken as instructed by doctor
  • Does not cause sleepiness

How it works

This medicine works by interfering with the normal clotting process and decreasing the clot forming ability of the blood.

Legal Status

Approved
Approved
Approved
Approved

Classification

Category
Heparins
Schedule
Schedule H

References

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Information on this page was last updated on 29 Aug 2017

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Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.