Terlipressin

Description

Terlipressin is used for the treatment of bleeding esophageal varices (dilated blood vessels of the esophagus) and type 1 hepatorenal syndrome (progressive kidney failure in people with severe liver damage). This medicine is not recommended for use in children.

Side effects

Major & minor side effects for Terlipressin

  • Headache
  • Abdominal cramps
  • Nausea
  • Diarrhea
  • Pale skin
  • Chest pain
  • Shortness of breath
  • Vomiting
  • Irregular heartbeat
  • Increased blood sugar levels

Uses of Terlipressin

What is it prescribed for?

  • Bleeding Esophageal Varices
  • Type 1 Hepatorenal Syndrome
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to terlipressin or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Septic shock

This medicine should be used with extreme caution in patients with septic shock due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Chronic kidney impairment

This medicine should be used with extreme caution in patients with an impaired kidney function due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Heart disorders

This medicine should be used with caution in patients with heart disorders such as arrhythmias, acute coronary syndrome, or recent myocardial infarction, etc due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Cerebral or peripheral vascular disorders

This medicine should be used with caution in patients with cerebral or peripheral vascular disorders due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Use in elderly

This medicine should be used with caution in patients aged above 70 years due to the increased risk of adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Use in children

This medicine is not recommended for use in children below 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of a missed dose is very less.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Aliskiren

antihistamines

Propofol

Erythromycin

Tricyclic Antidepressants

Class IA & III Antiarrythmic agents

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It works by narrowing the affected blood vessels and restricts the blood flow.
Legal Status

Approved

Unknown

Unknown

Approved

Classification

Category

Vasoconstrictor

Schedule

Schedule H

Terlipressin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 20 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB02638

Terlipressin acetate 0.12 mg/ml solution for injection - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 20 September 2018]. Available from:

https://www.medicines.org.uk/emc/product/2115/smpc

Terlipressin [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 20 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Terlipressin

[Internet]. Tga.gov.au. 2018 [cited 20 September 2018]. Available from:

https://www.tga.gov.au/sites/default/files/auspar-terlipressin-acetate-121126-pi.pdf

[Internet]. Medsafe.govt.nz. 2018 [cited 20 September 2018]. Available from:

http://www.medsafe.govt.nz/profs/Datasheet/g/Glypressin01mgmlFerringinj.pdf

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Information on this page was last updated on 16 May 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.