Teriparatide

Description

Teriparatide is a recombinant form of parathyroid hormone used for the treatment of osteoporosis. It is generally used in patients at a high risk of fractures. It is not recommended for use in patients at an increased risk of osteosarcoma. It is also not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Side effects

Major & minor side effects for Teriparatide

  • Abdominal pain
  • Loss of appetite
  • Weight loss
  • Vomiting
  • Muscle weakness
  • Increased urination
  • Dry mouth
  • Headache
  • Constipation
  • Injection site bruising and red coloration
  • Injection site pain

Uses of Teriparatide

What is it prescribed for?

  • Osteoporosis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before administering/receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to teriparatide or any other inactive ingredients present along with it.

Osteosarcoma

This medicine is not recommended for use in patients at a high risk of osteosarcoma or patients suffering from osteosarcoma (a type of bone cancer) due to the increased risk of worsening of the patient's condition.

Severe renal impairment

This medicine is not recommended for use in patients suffering from a severe impairment of kidney function due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before administering/receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings

Duration of Therapy

Use of this medicine for a duration of more than 2 years (24 months) is not recommended due to the increased risk of serious adverse effects.

Urolithiasis

This medicine should be used with caution in patients with active urolithiasis due to the increased risk of worsening of the patient's condition. Regular monitoring of serum calcium and uric acid levels may be necessary for these patients to safely use this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Renal impairment

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Liver impairment

This medicine should be used with caution in patients with a history of liver diseases due to the increased risk of severe adverse effects. Regular monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Paget's disease

This medicine should be used with caution in patients with a history of Paget's disease due to the increased risk of worsening of the patient's condition. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Driving or Operating machinery

Use of this medicine may cause symptoms such as dizziness, lightheadedness, fainting, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Administration

This medicine should be injected immediately after taking it out of the refrigerator. It is usually injected into the thigh or the abdominal wall. It should be administered when the patient is in a sitting or lying position to prevent orthostatic hypotension, which may cause symptoms such as dizziness, fainting, lightheadedness, etc. Your doctor or a healthcare professional will guide you about the use of the injection at home. If you are unable to understand how to use the injection or unable to self-administer the injection, you may need to visit the clinic/hospital for administration of the injection.

Missed Dose

The missed dose should be administered as soon as possible. It is advisable to skip the missed dose if it is almost time for your next scheduled dose. Do not administer extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Hydrochlorothiazide

Furosemide

Digoxin

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Carefully follow all the instructions given by your doctor and administer this medicine exactly as prescribed. Do not administer in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor. If you do not understand how to use the medicine at home or are unable to self-administer the medicine, you may need to visit the hospital/clinic for the administration of the injection.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by increasing the strength and density of bones. It also stimulates new bone formation in the body.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Parathyroid hormone and analogs

Schedule

Schedule H

Teriparatide (rDNA origin) Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 3 August 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a603018.html

Teriparatide - DrugBank [Internet]. Drugbank.ca. 2018 [cited 3 August 2018]. Available from:

https://www.drugbank.ca/drugs/DB06285

TGA eBS - Product and Consumer Medicine Information Licence [Internet]. Ebs.tga.gov.au. 2018 [cited 3 August 2018]. Available from:

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-CMI-06500-3

[Internet]. Uspl.lilly.com. 2018 [cited 3 August 2018]. Available from:

http://uspl.lilly.com/forteo/forteo.html#pi

Zotide Injection [Internet]. CiplaMed. 2018 [cited 3 August 2018]. Available from:

https://ciplamed.com/content/zotide-injection

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Information on this page was last updated on 22 Aug 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.