Tenofovir Disoproxil

Description

Tenofovir Disoproxil is an antiviral medicine which is used in combination with other antiretroviral agents to treat human immunodeficiency virus (HIV). It is also used for the treatment of chronic hepatitis B virus (HBV) infections. This medicine is not a cure for HIV or HBV. Close monitoring of liver function and kidney function is necessary while receiving this medicine.

Side effects

Major & minor side effects for Tenofovir Disoproxil

  • Headache
  • Cough
  • Back pain
  • Nausea and vomiting
  • Troubled breathing
  • swelling of face, finger or lower legs
  • Unusual tiredness or weakness
  • Increased blood pressure
  • Sleepiness
  • Loss of appetite
  • General feeling of discomfort
  • Diarrhea

Uses of Tenofovir Disoproxil

What is it prescribed for?

  • HIV infection
  • Chronic Hepatitis B
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1-2 hours of administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to tenofovir disoproxil or any other inactive ingredients present in the formulation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings

Lactic acidosis

This medicine should be used with caution due to the increased risk of lactic acidosis. Report any unusual symptoms to the doctor on priority. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Decreased bone mineral density

This medicine should be used with caution due to the increased risk of decreased bone mineral density. Report any unusual symptoms to the doctor on priority. Close monitoring of bone mineral density, appropriate corrective measures, and dose adjustments may be required in some cases based on the clinical condition.

Liver Toxicity

This medicine should be used with caution in patients with a history of liver disease and active liver disease due to the increased risk of worsening of the patient's condition. Hepatotoxicity has been reported in rare cases during treatment with this medicine. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to increased risk of severe adverse effects. Report any unusual symptoms to the doctor on priority. Close monitoring of kidney function tests, appropriate dose adjustments, or replacement with a suitable alternative is necessary in some cases based on the clinical condition.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Driving or Operating machinery

Use of this medicine may rarely cause dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any dizziness during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Neomycin

Ranitidine

Cyclosporine

Metformin

Rifabutin

Ibuprofen

Disease interactions

Kidney Disease

This medicine should be used with extreme caution in patients with kidney dysfunction due to increased risk of worsening of the patient's condition. Regular monitoring of kidney function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hepatotoxicity

This medicine should be used with caution in patients with pre-existing liver disease, history of alcohol abuse or hepatitis due to increased risk of worsening of patient's condition. Close monitoring of liver function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as instructed by the doctor. Do not take in larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It works by stopping the human immunodeficiency virus (HIV) and hepatitis B virus (HBV) from multiplying. This helps in reducing the chances of development of acquired immunodeficiency syndrome (AIDS) and other HIV and HBV-related illnesses.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Nucleoside reverse transcriptase inhibitors (NRTIs)

Schedule

Schedule H

[Internet]. Drugbank.ca. 2019 [cited 19 September 2019]. Available from:

https://www.drugbank.ca/drugs/DB00300

[Internet]. 2019 [cited 19 September 2019]. Available from:

https://www.glowm.com/resources/glowm/cd/pages/drugs/t009.html

[Internet]. Accessdata.fda.gov. 2019 [cited 19 September 2019]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022577lbl.pdf

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Information on this page was last updated on 20 Sep 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.