Tapentadol

Description

Tapentadol is an analgesic which is used to treat mild to severe pain. This medicine may cause addiction hence it should be taken under the supervision of a doctor. Do not take this medicine if you have any gastrointestinal disease or lung disease.

Side effects

Major & minor side effects for Tapentadol

  • Unusual tiredness and weakness
  • Headache
  • Difficulty in breathing
  • Agitation and anxiety
  • Drowsiness
  • Itching or rash
  • Constipation
  • Nausea
  • Decreased appetite
  • Increased sweating
  • Stomach discomfort and pain
  • Changes in vision

Uses of Tapentadol

What is it prescribed for?

  • Pain (Moderate to severe)
  • Neuropathic pain
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Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed in 1.25 hours for an immediate release tablet and 3 to 6 hours for an extended release.
  • Duration of effect
    The effect of this medicine can be observed for an average duration of 12 hours for an immediate release tablet and 15 to 18 hours for an extended release tablet.
  • Safe with alcohol?
    Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Do not perform activities that require mental alertness like driving or operating machinery.
  • Is it habit forming?
    Habit forming tendencies have been reported.
  • Usage in pregnancy?
    This medicine is not recommended for pregnant women unless absolutely necessary. The potential benefits and risks should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended in breastfeeding women.

Allergy

Not recommended in the patients with known allergy to Tapentadol

Lung disease

Not recommended in the patients with known history of lung diseases.

Monoamine oxidase inhibitors

Not recommended in the patients receiving monoamine oxidase inhibitors or who received monoamine oxidase inhibitors within 14 days.
Warnings for special population

Pregnancy

This medicine is not recommended for pregnant women unless absolutely necessary. The potential benefits and risks should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended in breastfeeding women.
General warnings

Addiction

Tapentadol has a high potential for addiction and abuse even at recommended dosages especially with the extended release form. You should be properly counseled about the abuse potential of this medicine. Proper safety monitoring and management of dose quantity is necessary in these cases.

Low blood pressure

Tapentadol can cause a temporary fall in blood pressure which can worsen based on posture (Orthostatic Hypotension). This can happen due to a pre-existing disease or other medications being administered at the same time. Proper clinical monitoring and dose adjustments are recommended in such cases.

Central nervous system depression

Tapentadol may impair the cognitive function. Patients receiving this medicine should be advised not to perform any activities that need mental alertness like driving or operating machinery.

Patients with head injury

Tapentadol should be used with caution in patients with head injury due to increase in the risk of intracranial pressure and coma

Withdrawal symptoms

Withdrawal of Tapentadol should be slow and steady especially with the extended release form of the medicine. Symptoms of withdrawal include tremors, nausea and vomiting, chills and fever, diarrhea and even hallucinations in some cases. The dose reduction should be based on the symptoms and should be properly tapered.

Use in children

Tapentadol is not recommended for use in children below 18 years of age as safety parameters are not established

Missed Dose

Take the missed dose as soon as you remember. The missed dose can be skipped if it is almost time for the next scheduled dose. For extended-release tablet or capsule skip the missed dose and continue with the regular dosing schedule.

Overdose

Seek emergency medical treatment or contact the doctor if any symptoms like sleepiness, slow breathing, loss of consciousness appear.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Consumption of alcohol may cause central nervous depression, impaired thinking due to an additive effect.

Instructions

Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Do not perform activities that require mental alertness like driving or operating machinery.
Interaction with Medicine

Alprazolam

Phenytoin

Codeine

Salmeterol

Disease interactions

Impaired gastrointestinal function

Tapentadol should be used with caution in patients with gastrointestinal disorders. Appropriate treatment should be initiated if any symptoms of constipation, irregular bowel movements have been reported. This medicine is not recommended in the patients with known case of infectious diarrhea.

Seizures

Tapentadol should be used with caution in the patients with the history of seizures. Inform the doctor if you experience any symptoms of seizures. A decision should be taken whether to discontinue the treatment based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Tapentadol with or without food. Do not take in larger amounts than advised. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine without consulting your doctor as it may cause withdrawal symptoms.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by acting on opioid receptors and alters the response of pain receptors.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Narcotic analgesics

Schedule

Schedule H

[Internet]. 2017 [cited 23 April 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/28373

DailyMed - tapentadol hydrochloride tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 23 April 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e35e8385-db1f-41a8-8307-20979569ac72

Tapentadol: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 23 April 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a610006.html

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 23 April 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname

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Information on this page was last updated on 16 Nov 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.