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Syntran 100 MG Capsule
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Syntran 100 MG Capsule

Manufactured byGlenmark Pharmaceuticals Ltd.
ContainsItraconazole
Description
Syntran 100 MG Capsule is an antifungal medicine used in the treatment of fungal infections in various parts of your body like the lungs, nails, mouth, throat, etc. It works by preventing the growth of fungi that are responsible for causing the infections. Syntran 100 MG Capsule may show some side effects such as diarrhoea, nausea, stomach pain, bloating, dizziness, fatigue, headache, menstrual problems, etc. If you notice any allergic reactions like a skin rash, tingling sensation in your arms and legs, difficulty in breathing, or swelling of your face, lips, tongue, or neck, seek emergency medical attention. Syntran 100 MG Capsule is recommended to be taken with food and plenty of water to ensure maximum absorption. Take it exactly as prescribed by your doctor. Even if your symptoms are relieved after a few days, do not stop taking this medication without consulting your doctor first. Sudden discontinuation may cause your infection to reappear and become resistant to further treatment. Consult your doctor if you do not notice any changes in your condition. Syntran 100 MG Capsule is not recommended if you have a history of heart failure. Inform your doctor if you have any other medical conditions, or if you are taking any medications. Avoid taking this medicine if you are pregnant, especially in the first trimester as it may cause harm to your foetus. If you are breastfeeding, take this medicine only after your doctor's recommendation.
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Side effectsConcernsUsageRelated products

Substitutes

List of substitutes for Syntran 100 MG Capsule

Canditz 100 MG Capsule
Glenmark Pharmaceuticals Ltd.
Sporanox 100 MG Capsule
Janssen India
Fungeeheal 100 mg Capsule
Lupin Ltd.
ITRALASE 100 CAPSULE
Cipla Ltd.
Livafin O 100 Capsule
Zydus Cadila

Side effects

Major & minor side effects for Syntran 100 MG Capsule

  • Diarrhoea
  • Fever
  • Heartburn
  • Gas or bloating
  • Sore or bleeding gums
  • Decreased sexual urge
  • Constipation
  • Dizziness
  • Nervousness
  • Blurred vision
  • Frequent urination
  • Ringing in ears
  • Nausea
  • Stomach pain
  • Problem in menstrual period
  • Headache
  • Fatigue

Uses of Syntran 100 MG Capsule

What is it prescribed for?

  • Blastomycosis
  • Histoplasmosis
  • Invasive Aspergillosis
  • Onychomycosis
  • Vulvovaginal Candidiasis
  • Pityriasis versicolor
  • Dermatophytoses
  • Oral candidiasis
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The time taken by Syntran 100 MG Capsule to show its effect is not clinically known. However, you need to take this medicine for a few months to see improvement in your infection.
  • How long do the effects of this medicine last?
    The time for which Syntran 100 MG Capsule remains in your body is around 6 days.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Syntran 100 MG Capsule.
  • Can this medicine be taken during pregnancy?
    Syntran 100 MG Capsule is not recommended for use in pregnancy, especially during the first trimester. Consult your doctor if you are pregnant, or are planning a pregnancy.
  • Can this medicine be taken while breast-feeding?
    Syntran 100 MG Capsule may be excreted in breast milk in a trace amount. Kindly consult your doctor before taking this medicine.

Allergy

Avoid taking Syntran 100 MG Capsule if you are allergic to Itraconazole or any other components present in the medicine. Seek immediate medical attention if you have symptoms such as skin rashes, itching/swelling (especially of the face/tongue/lips/throat), shortness of breath, etc.

QT interval prolongation

Syntran 100 MG Capsule may cause a problem in your heart rhythm called prolonged QT intervals (an electrical heartbeat disturbance), especially if you are taking it along with your heart medications. It may result in fast, rapid, and irregular heartbeats. Consult your doctor for further guidance in such conditions.

Congestive Heart Failure

Do not take Syntran 100 MG Capsule if you have a history of pre-existing congestive heart failure (a condition in which the heart is unable to pump blood efficiently) or other severe heart conditions as prolonged therapy with itraconazole may worsen your condition.
Warnings for special population

Pregnancy

Syntran 100 MG Capsule is not recommended for use in pregnancy, especially during the first trimester. Consult your doctor if you are pregnant, or are planning a pregnancy.

Breast-feeding

Syntran 100 MG Capsule may be excreted in breast milk in a trace amount. Kindly consult your doctor before taking this medicine.
General warnings

Liver diseases

Syntran 100 MG Capsule can cause moderate to severe side effects on your liver, and in a rare case, it may result in serious liver toxicity. If you have a history of liver problems, inform your doctor beforehand.

Hearing loss

Quinidine is a medicine used to treat irregular heartbeats. The use of Syntran 100 MG Capsule along with Quinidine may result in temporary or permanent hearing loss. When the treatment is discontinued after your doctor's advice, hearing loss usually resolves, but consult your doctor if it persists.

Driving or operating a machine

Therapy with Syntran 100 MG Capsule may cause dizziness, confusion, or disorientation in some cases. Hence, avoid activities such as driving vehicles or operating machines if you experience any of these symptoms.

Immunocompromised patients

If you have a weak or compromised immunity [e.g., in neutropenia (low level of white blood cells), AIDS (acquired immunodeficiency syndrome) or after organ transplantation], Syntran 100 MG Capsule may not be effective enough to treat the infection. Consult your doctor for further guidance in this regard.

Neuropathy

Neuropathy is a condition where there is destruction or dysfunction of one or more nerves, resulting in numbness, muscular weakness, tingling, and pain in the affected region. If you experience these symptoms while taking Syntran 100 MG Capsule, inform your doctor immediately. Discontinue the treatment only on your doctor’s recommendation.

Women of child bearing age

Women of childbearing age should use contraceptive precautions while taking Syntran 100 MG Capsule. Continue the use of contraceptives until the next menstrual cycle even after stopping the treatment.

Missed Dose

If you forget to take a dose of Syntran 100 MG Capsule, make sure that you take it as soon as you remember. However, do not take two doses together to make up for a forgotten dose.

Overdose

Never take more than the prescribed dose. If you suspect that you might have taken an overdose of Syntran 100 MG Capsule, seek immediate medical guidance.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Alprazolam

Erythromycin

Warfarin

Atorvastatin

Disease interactions

Liver Disease

Syntran 100 MG Capsule should be taken with caution if you have liver problems. This medicine is mostly metabolized in the liver, so you will be advised to monitor your liver function regularly.

Achlorhydria

Achlorhydria is a disorder in which your stomach fails to produce hydrochloric acid, a component of the stomach acid that is required for digestion. The absorption of Syntran 100 MG Capsule decreases when stomach acid is decreased. Take this medicine with caution if you are diagnosed with such conditions.
Food interactions
Take Syntran 100 MG Capsule with food as it helps to increase absorption from the stomach thereby giving better efficacy.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Syntran 100 MG Capsule should be taken orally with food exactly as prescribed by your doctor. Do not open, chew, or crush the capsule. Do not exceed the recommended dose. Take the medication at the same time every day. Antacid delays the absorption of this medicine hence, do not take antacids (stomach acid-reducing medicines) within two hours after taking Syntran 100 MG Capsule. If you notice any side effects, report them to your doctor as soon as possible. Your doctor may advise for some liver function tests before starting the treatment with Syntran 100 MG Capsule. If you observe any of the following symptoms like yellowing of the eyes or skin, black urine, or stomach discomfort, inform your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Syntran 100 MG Capsule works by stopping a chemical known as ergosterol, which is responsible for the formation of fungal cell membrane. Thus, by stopping this mechanism this medicine stops the growth and spread of fungal infection.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Azole antifungals

Schedule

Schedule H

Dailymed.nlm.nih.gov. 2021. DailyMed - ITRACONAZOLE- itraconazole capsules capsule. [online] Available at: < [Accessed 1 March 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1e243ffb-31be-39a7-4946-83ce7b839e0a>

Medicines.org.uk. 2021. Itraconazole 100 mg Capsules - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 1 March 2021].

https://www.medicines.org.uk/emc/medicine/32181>

Drugs, H., 2021. Itraconazole: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 1 March 2021].

https://medlineplus.gov/druginfo/meds/a692049.html>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 1 March 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020083s040s041s044lbl.pdf>
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Information on this page was last updated on 29 Aug 2021

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