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Synriam Tablet
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Synriam Tablet

Manufactured bySUN PHARMA LABORATORIES LTD
ContainsArterolane (150 mg) + Piperaquine (750 mg)
Description
Synriam Tablet is an antimalarial medicine which is used for the treatment of acute uncomplicated malaria infection due to Plasmodium falciparum.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Synriam Tablet

  • Stomach pain
  • Fatigue
  • Headache
  • Dizziness
  • Nausea and vomiting
  • Loss of appetite
  • Indigestion

Uses of Synriam Tablet

What is it prescribed for?

  • Malaria
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to arterolane, piperaquine, or any other inactive ingredients present along with the formulation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Cardiovascular diseases

This medicine should be used with extreme caution in patients suffering from cardiovascular diseases due to the increased risk of severe adverse effects including an irregular heart rhythm. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Vomiting

Use of this medicine may cause persistent vomiting in some patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in these cases based on the clinical condition.

Liver impairment

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Kidney impairment

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Other medicines

This medicine may interact with many other medicines and may cause adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Disease interactions

Disease

Information not available.
Food interactions
The absorption of this medicine is increased in the presence of fatty food and this may cause severe adverse effects such as an irregular heart rhythm in some patients. Hence, this medicine should be consumed on an empty stomach.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Arterolane gets accumulated in the food vacuole of the parasite and interferes with various processes needed for its survival. This ultimately results in the death of the parasite. Piperaquine works by increasing the concentration of a substance that inhibits the growth of the malarial parasite.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antimalarial agents, 4-Aminoquinolines

Schedule

Schedule H

Patil C. Fixed dose combination of arterolane and piperaquine: A newer prospect in antimalarial therapy. 2018. Available from:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160665/

[Internet]. Citeseerx.ist.psu.edu. 2018 [cited 10 April 2018]. Available from:

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.845.5085&rep=rep1&type=pdf

Arterolane [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 10 April 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Arterolane

Piperaquine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 10 April 2018]. Available from:

https://www.drugbank.ca/drugs/DB13941

Piperaquine: a resurgent antimalarial drug. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2018 [cited 10 April 2018]. Available from:

https://www.ncbi.nlm.nih.gov/pubmed/15610051
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Information on this page was last updated on 25 Jul 2019

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