Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition
General warnings
Skin and tissue disorders
This medicine should be used with caution since it may increase the risk of serious skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, etc. Report any unusual symptoms to the doctor on priority. Management of dermatological toxicities may include topical therapies for symptomatic relief, temporary treatment discontinuation and/or dose modification, or in severe or persistent cases, permanent discontinuation of the treatment. Patients are recommended to avoid sun exposure and should use sun protection.
Gastrointestinal disorders
Use of this medicine may cause gastrointestinal disorders such as diarrhea, nausea, vomiting, abdominal pain, indigestion, etc. Close monitoring and supportive care should be initiated is recommended in such cases.
Hypertension
This medicine should be used with caution in patients with increased blood pressure since it may worsen the condition. Appropriate dose adjustments and frequent clinical monitoring are advised. An alternative treatment option should be considered in some cases based on the clinical condition.
Haematological disorders
Use of this medicine may cause decreased neutrophil count and platelet counts. This medicine is not recommended for use in patients with lower values of absolute neutrophil count and platelet counts. Monitoring of these levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Cardiac disorders
This medicine may cause cardiovascular events such as heart failure, cardiomyopathy, left ventricular ejection fraction decline to below the lower limit of normal, myocarditis, myocardial ischemia, and heart attack. This medicine should be used with caution in patients who are suffering from heart diseases due to the increased risk of worsening of the patient's condition. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition of the patient.
Thyroid Disorder
Use of this medicine may cause hypothyroidism or hyperthyroidism, hence caution is advised in patients with thyroid dysfunction. Appropriate dose adjustments and frequent clinical monitoring are advised. An alternative treatment option may be necessary in some cases based on the clinical condition of the patient.
Liver toxicity
This medicine should be used with caution in patients with liver diseases due to the increased risk of serious adverse effects. Close monitoring of liver function is recommended for patients on treatment with this medicine. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments and frequent clinical monitoring are advised in such cases. An alternative treatment option may be necessary in some cases based on the clinical condition of the patient.
Hypoglycemia
This medicine may cause decreased blood sugar levels resulting in fainting and hospitalization. This medicine should be used with caution in patients with diabetes mellitus. Appropriate dose adjustments and frequent clinical monitoring are advised.
Kidney Disease
This medicine should be used with caution in patients with kidney diseases since it may worsen the condition. Close monitoring of kidney function tests and urine analysis is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Infections
Use of this medicine may affect the immune system making you susceptible to opportunistic infections from a wide variety of pathogens. It is advised to not use this medicine during an active infection. Use of this medicine should be discontinued after consulting the doctor if a serious infection develops.
Driving or Operating machinery
Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
Use in Children
This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.