Streptomycin

Description

Streptomycin is a broad-spectrum antibiotic which is used as the primary treatment of tuberculosis, a disease which mainly affects the respiratory system, and for certain other infectious diseases which affect the brain, the respiratory system, and the inner tissues of the heart, especially the valves.

Side effects

Major & minor side effects for Streptomycin

  • Allergy
  • Fever
  • Burning or tingling sensation
  • Vertigo
  • Nausea and vomiting
  • Difficult or painful urination
  • Blurred or double vision
  • Hearing impairment
  • Fast/irregular heart beat
  • Increased thirst

Uses of Streptomycin

What is it prescribed for?

  • Tuberculosis
  • Tularaemia
  • Bacterial endocarditis
  • Bacterial Meningitis
  • Plague
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. If this medicine is used, the infant should be monitored closely for adverse effects.

Allergy

This medicine is not recommended for use in patients with a known allergy to streptomycin or other aminoglycosides.

Hearing loss

Streptomycin is not recommended for use in patients with a hearing problem since it may increase the risk of deafness.

Impaired kidney function

Streptomycin is not recommended for use in patients with impaired kidney function since it may increase the risk of kidney injury. The risk is especially higher when high doses of this medicine are used for a prolonged period of time. Suitable dosage adjustments should be made on the basis of creatinine clearance.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. If this medicine is used, the infant should be monitored closely for adverse effects.
General warnings

Drug resistance

Use of Streptomycin without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

Route of administation

Streptomycin should be administered through the intramuscular route only.

Neuromuscular disorders

Streptomycin is not recommended for use in patients with existing neuromuscular diseases like Parkinsonism since it may worsen the condition of the patient.

Missed Dose

If a dose is missed, take the dose as soon as you remember it. If it is almost the time for the next dose, skip the missed dose and take the next dose. Do not double the dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Colistin

Furosemide

Neuromuscular blockers

Antiretroviral drugs

Disease interactions

Dehydration

Consume an adequate amount of water to prevent kidney injury and hearing problems. Fluid status should be monitored closely, especially in patients with severe diarrhea and vomiting who are receiving Streptomycin. Frequent monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments should be made based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
You are advised to take this medicine only in the presence of a trained healthcare professional. Strictly follow the instructions on the label and take Streptomycin only as directed. Drink plenty of water to avoid kidney damage. Do not take more than what is prescribed or share this medication with other people. It is advised that you should inform the doctor about all the medicines or herbal products that you are using and about all your medical conditions before taking this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Streptomycin kills the bacteria by blocking the production of certain proteins that are required for their growth.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Aminoglycosides

Schedule

Schedule H

DailyMed - STREPTOMYCIN- streptomycin injection, powder, lyophilized, for solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 20 July 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abd1f64e-4283-4370-aae8-3666316aa36e&audience=consumer

WHO Model Prescribing Information: Drugs Used in Mycobacterial Diseases: Tuberculosis: Streptomycin [Internet]. Apps.who.int. 2017 [cited 20 July 2017]. Available from:

http://apps.who.int/medicinedocs/en/d/Js5511e/2.6.html

(Streptomycin) dosing, indications, interactions, adverse effects, and more [Internet]. Reference.medscape.com. 2017 [cited 20 July 2017]. Available from:

http://reference.medscape.com/drug/streptomycin-342682

Streptomycin [Internet]. Snomedbrowser.com. 2017 [cited 20 July 2017]. Available from:

http://www.snomedbrowser.com/Codes/Details/387223008

TOXNET [Internet]. Toxnet.nlm.nih.gov. 2017 [cited 20 July 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~sDwmFR:7

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Information on this page was last updated on 28 Jul 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.