Streptokinase

Description

Streptokinase is an antithrombotic agent used to dissolve blood clots. It is used in the management of blood clots affecting the blood vessels of the heart, lungs, etc. This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

Side effects

Major & minor side effects for Streptokinase

  • Skin Rash
  • Flushing
  • Skin blistering
  • Shortness of breath
  • Low blood pressure
  • Nosebleed
  • Headache
  • Muscle pain and weakness
  • Diarrhea
  • Chills
  • Dizziness

Uses of Streptokinase

What is it prescribed for?

  • Acute myocardial infarction
  • Deep Vein Thrombosis
  • Pulmonary Embolism
  • Arterial thrombosis
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Concerns

Commonly asked questions

  • Onset of action
    On intravenous administration, the onset of action of this medicine is immediate.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 4 to 12 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a short period of time, based on your clinical condition. Replacement with a suitable alternative may be necessary in some cases.

Internal bleeding

This medicine is not recommended for use in patients with a known history of active or recent internal bleeding since it may worsen the patient's condition.

Intracranial neoplasm

This medicine is not recommended for use in patients with a known history of an intracranial tumor due to the increased risk of excessive bleeding.

Allergy

This medicine is not recommended for use in patients with a known allergy to streptokinase or any other inactive ingredients present along with it.

Surgery

This medicine is not recommended for use in patients with a recent history of intracranial or intraspinal surgery due to the increased risk of excessive bleeding.

Uncontrolled blood pressure

This medicine is not recommended for use in patients with a known history of uncontrolled blood pressure since it may worsen the patient's condition.

Head trauma

This medicine is not recommended for use in patients with a recent history of head trauma due to the increased risk of excessive bleeding.

Acute pancreatitis

This medicine is not recommended for use in patients with a known history of acute pancreatitis since it may worsen the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a short period of time, based on your clinical condition. Replacement with a suitable alternative may be necessary in some cases.
General warnings

Head injury

This medicine is not recommended for use in patients with a recent history of head injury due to the increased risk of excessive bleeding. Replacement with a suitable alternative should be considered under your doctor's supervision.

Bleeding disorders

This medicine is not recommended for use in patients with a known history of bleeding disorders due to the increased risk of worsening of the patient's condition.

Kidney diseases

This medicine should be used with extreme caution in patients with a known history of kidney diseases due to the increased risk of worsening of the patient's condition. Frequent monitoring of kidney function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Hepatic diseases

This medicine should be used with extreme caution in patients with a known history of hepatic diseases due to the increased risk of worsening of the patient's condition. Frequent monitoring of liver function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Cerebrovascular diseases

This medicine should be used with extreme caution in patients with a known history of cerebrovascular diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Surgey

This medicine is not recommended for use in patients with a recent history of a surgery due to the increased risk of excessive bleeding.

High blood pressure

This medicine should be used with extreme caution in patients with a known history hypertension (high blood pressure) due to the increased risk of worsening of the patient's condition. Frequent monitoring of blood pressure is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Missed Dose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of missing a dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Citalopram

Fluoxetine

Lisinopril

Diclofenac

Anticoagulants

Disease interactions

Lung disease

This medicine should be used with caution in patients with lung diseases since it may worsen the patient's condition. Close monitoring of lung function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Bleeding disorders

This medicine is not recommended for use in patients with bleeding disorders since it may worsen the patient's condition. Replacement with a suitable alternative should be considered under your doctor's supervision.

Uncontrolled hypertension

This medicine is not recommended for use in patients with uncontrolled hypertension since it may worsen the patient's condition. Replacement with a suitable alternative should be considered under your doctor's supervision.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is administered by a qualified healthcare professional in the clinical or hospital setting. Carefully follow all the instructions given by your doctor. Inform the doctor if you have an allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine increases the formation of an enzyme (plasmin) which is responsible for the breakdown of blood clots.
Legal Status

Approved

Unknown

Approved

Unknown

Classification

Category

Thrombolytics

Schedule

Schedule H

[Internet]. 2017 [cited 26 October 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.29056.latest.pdf

[Internet]. 2017 [cited 26 October 2017]. Available from:

http://www.mhra.gov.uk/home/groups/spcpil/documents/spcpil/con1443763131869.pdf

[Internet]. 2017 [cited 26 October 2017]. Available from:

http://www.cslbehring.ca/docs/831/938/Streptase_app%2029mar07.pdf

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Information on this page was last updated on 30 Oct 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.