Spiramycin

Description

Spiramycin is a macrolide antibiotic which is used to treat bacterial and parasitic infections of the respiratory tract, mouth, skin, and soft tissues. It is used to treat toxoplasmosis infection in pregnant women under specific circumstances which are clinically determined. It may also be used to treat gonorrhea in patients who are allergic to penicillin.

Side effects

Major & minor side effects for Spiramycin

  • Nausea and Vomiting
  • Diarrhea
  • Abnormal liver function
  • Skin rash
  • Swelling of eyelids, face, lips, tongue
  • Peeling and blistering of skin
  • Vasculitis
  • Burning and stinging
  • Change in heart rate
  • Abnormal blood counts
  • Fall in blood pressure

Uses of Spiramycin

What is it prescribed for?

  • Bacterial infections
  • Toxoplasmosis
  • Gonorrhea
Read More
Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed within 3-4 hours of administration of an oral dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the potential benefits and risks associated with use must be considered before initiating treatment with this medicine. Your doctor will determine the best course of treatment after clinically evaluating your condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the potential benefits and risks associated with use must be considered before initiating treatment with this medicine. Your doctor will determine the best course of treatment after clinically evaluating your condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to spiramycin, any other antibiotic of the macrolide drug class, or any other inactive ingredients present along with it.

Bacterial Meningitis

This medicine is not recommended for use in patients with bacterial meningitis due to its inefficiency of crossing the blood-brain barrier.

Toxoplasma encephalitis

This medicine is not recommended for use in patients with toxoplasma encephalitis due to its inefficiency of crossing the blood-brain barrier.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the potential benefits and risks associated with use must be considered before initiating treatment with this medicine. Your doctor will determine the best course of treatment after clinically evaluating your condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the potential benefits and risks associated with use must be considered before initiating treatment with this medicine. Your doctor will determine the best course of treatment after clinically evaluating your condition.
General warnings

Other medicines

Report the use of all medicines, including herbs and supplements, to the doctor in order to rule out the chances of drug interactions. Your doctor may suggest appropriate dose adjustments or replacement with suitable alternatives based on the medicines you are currently taking.

Electrolyte disturbances

This medicine should be used with caution in patients with imbalanced levels of electrolytes viz. potassium, magnesium, etc. due to the increased risk of worsening of the patient’s condition. Appropriate dose adjustments, corrective measures, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Heart diseases

This medicine should be used with caution in patients with heart diseases due to the increased risk of severe adverse effects. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition of the patient.

QT prolongation

This medicine should be used with caution in patients with prolonged QT interval or patients who are undergoing therapy with medicines which may prolong the QT interval such as antipsychotics, tricyclic antidepressants, etc. due to the increased risk of worsening of the patient’s condition. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition of the patient.

Use in elderly

This medicine should be used with caution in elderly patients since the risk of severe adverse effects is significantly higher. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Drug resistance

It is advised to continue the usage of this medicine for the prescribed duration even when there is a marked improvement in symptoms. Failure to do so may result in drug resistance and may cause superinfections that are difficult to treat.

Cross resistance

This medicine may not be effective in the treatment of infections where the causative organism has developed a resistance to erythromycin. Instances of cross-resistance should be clinically evaluated before initiation of treatment with this medicine.

Skin reactions

This medicine should be used with caution since it may increase the risk of serious skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, etc. Report any unusual symptoms to the doctor on priority. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Levodopa

Antipsychotics

Quinidine

Chlorpromazine

Warfarin

Carbidopa

Tricyclic Antidepressants

Disease interactions

Impaired liver function

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hemolytic Anemia/G6PD Deficiency

This medicine should be used with extreme caution in patients who are suffering from hemolytic anemia or G6PD Deficiency due to the increased risk of worsening of the patient’s condition. An alternative treatment option may be necessary in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions

ALT, SGPT

Report the use of this medicine to the doctor if you are undergoing this test. A false result may be obtained if this test is performed during treatment with this medicine. It is advised that you report the use of all your current medicines, including any herbs and supplements, to the doctor before undergoing this test. Do not stop the use of any medicine without consulting your doctor.
Take this medicine at least 30 minutes before or 2 hours after the meals. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by interfering with certain vital processes in the cells of the target organism.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Macrolides

Schedule

Schedule H

[Internet]. Pdf.hres.ca. 2018 [cited 17 August 2018]. Available from:

https://pdf.hres.ca/dpd_pm/00044997.PDF

Spiramycin [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 17 August 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/spiramycin#section=Top

Spiramycin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 17 August 2018]. Available from:

https://www.drugbank.ca/drugs/DB06145

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Information on this page was last updated on 24 Dec 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.