Somatostatin

Description

Somatostatin is a growth hormone-inhibiting hormone used for the symptomatic treatment of acute bleeding from gastrointestinal ulcers. It may also be used in the treatment of acute pancreatitis.

Side effects

Major & minor side effects for Somatostatin

  • Abdominal discomfort
  • Nausea
  • Flushing
  • Slow heart rate
  • Palpitations
  • Vomiting
  • Diarrhea
  • Indigestion
  • Chills
  • Fatigue
  • Injection site pain
  • Skin rash

Uses of Somatostatin

What is it prescribed for?

  • Gastrointestinal haemorrhage
  • Acute pancreatitis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to somatostatin, somatostatin analogs, or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Blood glucose levels

This medicine may alter the blood glucose levels in some patients. This risk is especially high in patients suffering from diabetes mellitus. Close monitoring of blood glucose levels, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Missed Dose

Since this medicine is administered by a qualified healthcare professional, the likelihood of missing a dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Bromocriptine

Phenobarbital

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered only by a qualified healthcare professional. Inform the doctor if you have a known allergy to this medicine. Report to the doctor all your current medicines including herbs and supplements as well as all your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by reducing blood flow in the gastrointestinal tract. It also decreases the secretion of some gastrointestinal hormones and gastric acid. These actions help in controlling bleeding from the gastrointestinal tract.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Growth hormone-inhibiting hormone (GHIH), Peptide hormone

Schedule

Schedule H

Somatostatin - DrugBank [Internet]. [cited 13 April 2018]. Available from:

https://www.drugbank.ca/drugs/DB09099

Somatostatin and Somatostatin Receptors: from Basic Concepts to Clinical Applications. [Internet]. [cited 13 April 2018]. Available from:

http://europepmc.org/abstract/med/20541669

Somatostatin system: molecular mechanisms regulating anterior pituitary hormones. [Internet]. [cited 13 April 2018]. Available from:

http://jme.endocrinology-journals.org/content/53/1/R1.full

Somatostatin [Internet]. Available from: [Internet]. [cited 13 April 2018]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/somatostatin

https://pubchem.ncbi.nlm.nih.gov/compound/somatostatin

Somatostatin in the treatment of acute pancreatitis: a prospective randomised controlled trial. [Internet]. [cited 13 April 2018]. Available from:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1378305/

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Information on this page was last updated on 25 Apr 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.