Sirolimus
Description
Sirolimus is an immunosuppressant medicine used along with other medicines to prevent the body from rejecting a kidney transplant. This medicine is not recommended for use in children less than 13 years of age.
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Side effects
Major & minor side effects for Sirolimus
- Hypersensitivity
- Unusual bleeding or bruising
- Cough
- Cracked or scaly skin
- Abdominal and stomach pain
- Constipation or diarrhea
- Nausea
- Upper respiratory tract infection
- Urinary tract infection
- Difficulty in breathing
- Jaundice
- Tinnitus
- Nervousness and confusion
Uses of Sirolimus
What is it prescribed for?
- Organ Transplant - Rejection Prophylaxis
- Pulmonary lymphangioleiomyomatosis
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Concerns
Commonly asked questions
- Onset of actionThe amount of time required for this medicine to show its effect is not clinically established.
- Duration of effectSirolimus remains active in the body for up to 24 hours after administration.
- Safe with alcohol?Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is it habit forming?No habit forming tendencies were reported.
- Usage in pregnancy?This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
- Usage while breast-feeding?This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
Allergy
This medicine is not recommended for use in patients with a known allergy to sirolimus or any other components present along with it.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings
Use in pediatrics
This medicine is not recommended for use in children less than 13 years of age.
Blood pressure
This medicine may cause an increase in blood pressure. Close monitoring of blood pressure is necessary during treatment with this medicine.
Use of contraception
Women of childbearing age are advised to use effective contraception prior to, during, and for 12 weeks following treatment with this medicine to avoid pregnancy. This medicine may cause serious side effects in the fetus.
Missed Dose
If you miss a dose of Sirolimus, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Overdose
Seek emergency medical treatment or contact a doctor immediately in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Erythromycin
Rifampicin
Live vaccines
NSAIDs
Antibiotics
Disease interactions
Infections
Caution is advised while using this medicine in patients who are at risk of chronic or severe infections. Patients receiving this medicine should be monitored closely for any signs of infection. It is advised to interrupt the therapy if there are any signs of a new infection and take appropriate corrective measures.
Progressive multifocal leukoencephalopathy
This medicine is not recommended for use in patients with active or a previous history of Progressive multifocal leukoencephalopathy (PML). In patients at risk of developing this condition, this medicine should be used with extreme caution and the patient should be monitored closely for any signs of PML. It is advised to interrupt therapy if any signs of PML appear and take appropriate corrective measures.
Angioedema
Sirolimus should be used with extreme caution in patients who are at increased risk of angioedema. Close monitoring of such patients for any signs of angioedema is recommended.
Hyperlipidemia
Caution is advised while using this medicine in patients with hyperlipidemia since this medicine may further increase the cholesterol and triglycerides levels. Close monitoring of cholesterol levels is necessary for such patients.
Impaired liver function
Caution is advised while using this medicine in patients with impaired liver function due to the increased risk of severe adverse effects. Appropriate dose adjustments should be made based on the severity of the liver impairment. Close monitoring of liver function is necessary for such patients.
Lung dysfunction
Caution is advised while using this medicine in patients with lung diseases due to the increased risk of severe and life-threatening side effects. Close monitoring of pulmonary symptoms and lung function is necessary for such patients. It is advised to interrupt therapy if any signs of adverse lung effects occur and take appropriate corrective measures.
Renal Dysfunction
Caution is advised while using this medicine along with cyclosporine due to the increased risk of severe kidney problems. Close monitoring of kidney function is recommended during treatment with these medicines. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Food interactions
Consumption of grapefruit or grapefruit juice is not recommended during treatment with this medicine due to the increased risk of serious adverse effects.
Lab interactions
Information not available.
Take Sirolimus as advised by your doctor. Do not take in larger amounts than advised or share this medicine with others. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous
How it works
This medicine works by suppressing the immune system which is primarily responsible for organ rejection after a transplant has been completed.
Legal Status
Classification
Category
Immunosuppressive agents
Schedule
Schedule H
Sirolimus: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 7 August 2017]. Available from:
[Internet]. 2017 [cited 7 August 2017]. Available from:
[Internet]. 2017 [cited 7 August 2017]. Available from:
Sirolimus: sirolimus tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 7 August 2017]. Available from:
Sirolimus: DrugBank [Internet]. Drugbank.ca. 2017 [cited 7 August 2017]. Available from:
Sirolimus [Internet]. Snomedbrowser.com. 2017 [cited 7 August 2017]. Available from:
Information on this page was last updated on 11 Aug 2017
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.