Silver Sulfadiazine

Description

Silver Sulfadiazine is a topical antibiotic used for the prevention and treatment of wound infections in patients with second and third-degree burns. This medicine is not recommended for use in patients less than 18 years of age.

Side effects

Major & minor side effects for Silver Sulfadiazine

  • Burning sensation at the application site
  • Itching of skin
  • Skin rash
  • Yellowing of skin and eyes
  • Redness of skin
  • Dark colored urine

Uses of Silver Sulfadiazine

What is it prescribed for?

  • Burn wound infections
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to silver sulfadiazine, silver, or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Hypersensitivity reactions

This medicine should be used with caution in patients with severe allergies, bronchial asthma, or AIDS due to the increased risk of severe hypersensitivity reactions. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Crystalluria

Use of this medicine may cause crystalluria due to the precipitation of this medicine in the urinary tract. This risk is especially higher in patients suffering from dehydration. Patients are advised to drink an adequate amount of water during treatment with this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency

This medicine should be used with extreme caution in patients with Glucose-6-phosphate dehydrogenase (G6PD) deficiency due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Use in pediatrics

This medicine is not recommended for use in patients less than 18 years of age.

Missed Dose

Use/apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

An overdose of this medicine is not likely to cause severe symptoms. However, ingestion of this medicine may cause harm and immediate medical intervention may be required.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Sodium Nitrite

Prilocaine

Collagenase

Disease interactions

Bone Marrow Depression/Blood Dyscrasias

This medicine should be used with extreme caution in patients with preexisting blood dyscrasias or bone marrow suppression due to the increased risk of worsening of the patient's condition. Report any signs or symptoms such as a fever, sore throat, local infection, bleeding, pallor, dizziness, or jaundice to the doctor immediately. Close monitoring of complete blood counts is recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Porphyria

This medicine should be used with caution in patients suffering from porphyria due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Liver impairment

This medicine should be used with caution in patients with liver impairment due to the increased risk of severe adverse effects. Close monitoring of liver function may be required while using this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Renal impairment

This medicine should be used with caution in patients with renal impairment due to the increased risk of severe adverse effects. Close monitoring of renal function may be required while using this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is meant for external use only. If the medicine is swallowed, seek immediate medical help. Follow all dosing instructions mentioned on the label or the package insert. Do not use this medicine for durations shorter or longer than recommended by your doctor. Ensure that the treatment course is completed. Report any undesired side effects to the doctor immediately. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine acts on the cell wall and cell membrane of the bacteria to cause their death.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Topical antibiotics

Schedule

OTC

Silver Sulfadiazine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 12 April 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a682598.html

DailyMed - Silver sulfadazine cream [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 12 April 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c2b6aaa5-3325-403c-9466-977c4f63f36f

Silver sulfadiazine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 12 April 2018]. Available from:

https://www.drugbank.ca/drugs/DB05245

[Internet]. Accessdata.fda.gov. 2018 [cited 12 April 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/017381s050lbl.pdf

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Information on this page was last updated on 6 Jun 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.