Sibutramine

Description

Sibutramine is an anorexiant used for the treatment of obesity. Patients are advised to follow a proper diet and exercise along with this medicine to control weight. Regular monitoring of liver and kidney function tests is necessary while receiving this medicine.

Side effects

Major & minor side effects for Sibutramine

  • Back pain
  • Dizziness
  • Constipation
  • Increased heartbeat
  • Anxiety
  • Gastritis
  • Abdominal pain
  • Migraine
  • Vomiting
  • Increased cough
  • Acne
  • Urinary retention

Uses of Sibutramine

What is it prescribed for?

  • Obesity
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    Use of this medicine may cause habit-forming tendencies in some cases especially if the usage is for an extended period of time. A gradual withdrawal of the drug i.e. decrease in dosing over a period of time is suggested in such cases.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to sibutramine, or any other inactive ingredients present in the formulation.

Anorexia Nervosa

This medicine is not recommended for use in patients who are suffering from the eating disorder due to the increased risk of worsening of the patient's condition.

Monoamine oxidase inhibitors (MAOI)

This medicine is not recommended for use in patients taking monoamine oxidase inhibitors (MAOI) due to the increased risk of serious and life-threatening side effects. A time gap of at least 14 days should be maintained between stopping therapy with MAOIs and starting therapy with this medicine.

Severe Liver/Kidney Impairment

This medicine is not recommended for use in patients with severe liver or kidney diseases due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Heart Diseases

This medicine should be used with caution in patients with heart diseases due to the increased risk of a rise in blood pressure and heart rate. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Use in Children

This medicine is not recommended for use in patients below 16 years of age since the safety and efficacy of use are not clinically established.

Seizures

This medicine should be used with caution in patients with seizures due to increased risk worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amitriptyline

Ondansetron

Tramadol

Formoterol

Bupropion

Aspirin

Disease interactions

Glaucoma

This medicine should be used with caution in patients with narrow-angle glaucoma due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney/Liver Disease

This medicine should be used with caution in patients with kidney/liver diseases due to the increased risk of adverse effects. Close monitoring of liver or kidney function tests is necessary while taking this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Diabetes Mellitus

This medicine should be used with caution in patients with diabetes due to the increased risk of hypoglycemia. Regular monitoring of blood glucose levels, dose adjustments of antidiabetic agents, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as instructed by the doctor. Do not take in larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by altering the neurotransmitters in the brain that helps in weight loss maintenance.
Legal Status

Banned

Unknown

Unknown

Unknown

Classification

Category

Anorexiants

Schedule

Schedule H

Sibutramine - DrugBank [Internet]. Drugbank.ca. 2019 [cited 27 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB01105

[Internet]. 2018 [cited 27 December 2018]. Available from:

https://www.glowm.com/resources/glowm/cd/pages/drugs/s009.html

[Internet]. Accessdata.fda.gov. 2018 [cited 27 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020632s032lbl.pdf

Sibutramine [Internet]. Pubchem.ncbi.nlm.nih.gov. 2019 [cited 27 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/sibutramine#section=3D-Conformer

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Information on this page was last updated on 27 Aug 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.