Secukinumab

Description

Secukinumab is an interleukin inhibitor used for the treatment of moderate to severe plaque psoriasis (a skin disease characterized by red, scaly patches on some areas of the body) in adults patients, where the systemic therapy is appropriate. It is also used to treat active psoriatic arthritis and active ankylosing spondylitis in adults. This medicine is not recommended for use in patients below 18 years of age.

Side effects

Major & minor side effects for Secukinumab

  • Headache
  • Muscle pain
  • Fever
  • Chills
  • Cough
  • Unusual tiredness or weakness
  • Runny Nose
  • Sore throat
  • Ear congestion
  • Itching or skin rash
  • Fast heartbeat
  • Severe stomach pain
  • Dizziness

Uses of Secukinumab

What is it prescribed for?

  • Ankylosing Spondylitis
  • Psoriatic Arthritis
  • Plaque Psoriasis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to secukinumab, or any other inactive ingredients present in the formulation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Serious infections

Use of this medicine may affect the immune system, making you susceptible to opportunistic infections from a wide variety of pathogens. Use of this medicine is not recommended if you have an active infection. If a serious infection develops, consult your doctor immediately and discontinue the use of this medicine based on the doctor's advice.

Use of vaccines

Administration of live or live attenuated vaccines is not recommended during treatment with this medicine due to the increased risk of worsening of the patient's condition. Your doctor may advise you to postpone vaccination or may use an appropriate form of vaccination with adequate clinical monitoring to minimize the risk of adverse effects.

Use in Children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low. If you miss an appointment for a scheduled dose of this medicine, contact your doctor immediately for further instructions.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clonazepam

Leflunomide

Live attenuated vaccines and related products

Etanercept

Lidocaine

Infliximab

Adalimumab

Felodipine

Teriflunomide

Dicumarol

Amlodipine

Phenytoin

Clobazam

Certolizumab

Disease interactions

Inflammatory bowel disease

This medicine should be used with caution in patients with inflammatory bowel disease due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor on priority. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Tuberculosis

This medicine should be used with extreme caution in patients who have previously been treated for latent or active tuberculosis. Anti-tuberculosis therapy should be initiated prior to therapy with this medicine if an active infection is confirmed. Appropriate tests should be conducted for the presence of latent tuberculosis in patients before initiating therapy with this medicine.

Infections

This medicine should be used with extreme caution in patients with a history of recurrent infections due to the increased risk of worsening of the patient’s condition. Initiation of therapy with this medicine in patients with active infections is not recommended. Patients susceptible to infections should be monitored closely during treatment with this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines including any herbs and supplements as well as your medical conditions before receiving this medicine. Consult your doctor immediately if you develop any signs and symptoms of an infection.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by blocking the action of certain chemicals in the body which are responsible for the symptoms of psoriasis.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Interleukin inhibitors

Schedule

Schedule H

[Internet]. Ema.europa.eu. 2019 [cited 26 March 2019]. Available from:

https://www.ema.europa.eu/en/documents/product-information/cosentyx-epar-product-information_en.pdf

Cosentyx 150 mg solution for injection in pre-filled pen - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2019 [cited 26 March 2019]. Available from:

https://www.medicines.org.uk/emc/product/3669/smpc#

DailyMed - COSENTYX- secukinumab injection [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 26 March 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=77c4b13e-7df3-42d4-81db-3d0cddb7f67a

Secukinumab - DrugBank [Internet]. Drugbank.ca. 2019 [cited 26 March 2019]. Available from:

https://www.drugbank.ca/drugs/DB09029

Secukinumab Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 26 March 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a615011.html

[Internet]. Accessdata.fda.gov. 2019 [cited 26 March 2019]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/125504s013lbl.pdf

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Information on this page was last updated on 14 Aug 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.