Saxagliptin
Description
Saxagliptin is an antidiabetic medicine used in the treatment of type 2 diabetes in adult patients. Patients are advised to follow a strict diet and exercise regimen along with this medicine for the best possible effect. This medicine is not recommended for use in patients with type 1 diabetes and diabetic ketoacidosis.
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Side effects
Major & minor side effects for Saxagliptin
- Anxiety
- Blurred vision
- Chills
- Confusion
- Nausea
- Headache
- Runny Nose
- Sneezing
- Rapid weight gain
- Fever
- Vomiting
Uses of Saxagliptin
What is it prescribed for?
- Type II Diabetes Mellitus
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Concerns
Commonly asked questions
- Onset of actionThe peak effect of this medicine can be observed after 2 hours of administration.
- Duration of effectThe amount of time for which this medicine remains active in the body is not clinically established.
- Safe with alcohol?Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
- Is it habit forming?No habit forming tendencies were reported.
- Usage in pregnancy?This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
- Usage while breast-feeding?This medicine is not recommended for use in breastfeeding women unless absolutely necessary. If the medicine is used, close monitoring of the infant for any undesired side effects is recommended.
Allergy
This medicine is not recommended for use in patients with a known allergy to saxagliptin.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. If the medicine is used, close monitoring of the infant for any undesired side effects is recommended.
General warnings
Use in children
This medicine is not recommended for use in children and adolescents.
Thiazolidinediones
This medicine should be used with caution in patients receiving thiazolidinediones due to the increased risk of peripheral edema.
Bullous pemphigoid
This medicine should be used with caution due to the increased risk of bullous pemphigoid, a hypersensitivity reaction of the skin. Any unusual symptoms such as skin blisters or skin rashes should be reported to the doctor on priority. Therapy with the medicine may be discontinued based on the clinical condition of the patient.
CYP450 3A4/5 inhibitors
This medicine should be used with caution in patients receiving CYP450 3A4/5 inhibitors due to the increased risk of severe side effects. Appropriate dose adjustments should be done based on the clinical condition of the patient.
Congestive heart failure
This medicine should be used with caution in patients with a known history of congestive heart failure due to the increased risk of worsening of the patient's condition.
Missed Dose
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
N/A
Instructions
Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
Interaction with Medicine
Clozapine
Amiodarone
Captopril
Acetazolamide
Gatifloxacin
Benazepril
Bexarotene
Disease interactions
Pancreatitis
This medicine should be used with extreme caution in patients with a known history of pancreatitis due to the increased risk of recurrent pancreatitis. Report any symptoms such as abdominal pain, nausea, vomiting, etc. to the doctor immediately. Therapy with the medicine may be discontinued based on the clinical condition of the patient.
Renal Dysfunction
This medicine should be used with extreme caution in patients with a history of kidney diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments should be done based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Saxagliptin with or without food. Do not crush or chew the tablet. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous
How it works
Saxagliptin increases insulin and lowers glucagon production. This results in lowering of the blood glucose levels.
Legal Status
Classification
Category
Dipeptidyl peptidase 4 inhibitors
Schedule
Schedule H
DailyMed - ONGLYZA- saxagliptin tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 21 August 2017]. Available from:
EMC [Internet]. 2017 [cited 21 August 2017]. Available from:
Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 21 August 2017]. Available from:
Saxagliptin - DrugBank [Internet]. Drugbank.ca. 2017 [cited 21 August 2017]. Available from:
Saxagliptin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 21 August 2017]. Available from:
TOXNET [Internet]. Toxnet.nlm.nih.gov. 2017 [cited 21 August 2017]. Available from:
Information on this page was last updated on 30 Oct 2017
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.