Saxagliptin

Description

Saxagliptin is an antidiabetic medicine used in the treatment of type 2 diabetes in adult patients. Patients are advised to follow a strict diet and exercise regimen along with this medicine for the best possible effect. This medicine is not recommended for use in patients with type 1 diabetes and diabetic ketoacidosis.

Side effects

Major & minor side effects for Saxagliptin

  • Anxiety
  • Blurred vision
  • Chills
  • Confusion
  • Nausea
  • Headache
  • Runny Nose
  • Sneezing
  • Rapid weight gain
  • Fever
  • Vomiting

Uses of Saxagliptin

What is it prescribed for?

  • Type II Diabetes Mellitus
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Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed after 2 hours of administration.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. If the medicine is used, close monitoring of the infant for any undesired side effects is recommended.

Allergy

This medicine is not recommended for use in patients with a known allergy to saxagliptin.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. If the medicine is used, close monitoring of the infant for any undesired side effects is recommended.
General warnings

Use in children

This medicine is not recommended for use in children and adolescents.

Thiazolidinediones

This medicine should be used with caution in patients receiving thiazolidinediones due to the increased risk of peripheral edema.

Bullous pemphigoid

This medicine should be used with caution due to the increased risk of bullous pemphigoid, a hypersensitivity reaction of the skin. Any unusual symptoms such as skin blisters or skin rashes should be reported to the doctor on priority. Therapy with the medicine may be discontinued based on the clinical condition of the patient.

CYP450 3A4/5 inhibitors

This medicine should be used with caution in patients receiving CYP450 3A4/5 inhibitors due to the increased risk of severe side effects. Appropriate dose adjustments should be done based on the clinical condition of the patient.

Congestive heart failure

This medicine should be used with caution in patients with a known history of congestive heart failure due to the increased risk of worsening of the patient's condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
Interaction with Medicine

Clozapine

Amiodarone

Captopril

Acetazolamide

Gatifloxacin

Benazepril

Bexarotene

Disease interactions

Pancreatitis

This medicine should be used with extreme caution in patients with a known history of pancreatitis due to the increased risk of recurrent pancreatitis. Report any symptoms such as abdominal pain, nausea, vomiting, etc. to the doctor immediately. Therapy with the medicine may be discontinued based on the clinical condition of the patient.

Renal Dysfunction

This medicine should be used with extreme caution in patients with a history of kidney diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments should be done based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Saxagliptin with or without food. Do not crush or chew the tablet. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Saxagliptin increases insulin and lowers glucagon production. This results in lowering of the blood glucose levels.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Dipeptidyl peptidase 4 inhibitors

Schedule

Schedule H

DailyMed - ONGLYZA- saxagliptin tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 21 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c5116390-e0fe-4969-94cb-e9de5165fbab

EMC [Internet]. 2017 [cited 21 August 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/22315

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 21 August 2017]. Available from:

http://www.tga.gov.au/prescribing-medicines-pregnancy-database

Saxagliptin - DrugBank [Internet]. Drugbank.ca. 2017 [cited 21 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB06335

Saxagliptin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 21 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a610003.html

TOXNET [Internet]. Toxnet.nlm.nih.gov. 2017 [cited 21 August 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2

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Information on this page was last updated on 30 Oct 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.