S-Adenosyl Methionine

Description

S-Adenosyl Methionine is a naturally occurring chemical in the body which is responsible for formation, breakdown, and activation of other chemicals in the body such as proteins, phospholipids, hormones, etc.

Side effects

Major & minor side effects for S-Adenosyl Methionine

  • Headache
  • Feeling anxious or nervous
  • Vomiting
  • Abdominal pain
  • Diarrhea
  • Insomnia
  • Increased sweating
  • Nausea
  • Dizziness

Uses of S-Adenosyl Methionine

What is it prescribed for?

  • Depression
  • Osteoarthritis
  • Alcohol related liver disease
  • Intrahepatic cholestasis
  • Fibromyalgia
Read More
Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this supplement to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this supplement remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This supplement is not recommended for use in patients with a known allergy to S-Adenosyl Methionine or any other components present along with it.

Monoamine oxidase inhibitors (MAO)

This supplement is not recommended for use in patients undergoing treatment with MAO inhibitors such as rasagiline, selegiline, etc. due to the increased risk of serotonin syndrome. A time gap of at least 14 days is recommended between stopping MAO therapy and beginning S-Adenosyl Methionine therapy.

Use in children

S-Adenosyl Methionine is not recommended for use in children and adolescents since the safety and efficacy of use are not clinically established.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Bipolar disorder

S-Adenosyl Methionine should be used with caution in patients with a known history of bipolar disorder due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Renal impairment

S-Adenosyl Methionine should be used with caution in patients with a known history of renal impairment due to the increased risk of adverse effects. Appropriate dose adjustments should be considered under your doctor's supervision.

Elderly patients

S-Adenosyl Methionine should be used with caution in elderly patients due to the increased risk of adverse effects. Appropriate dose adjustments should be considered under your doctor's supervision.

Driving or using machines

This supplement may cause dizziness. It is recommended that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you experience dizziness during treatment with S-Adenosyl Methionine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amitriptyline

Clomipramine

Desvenlafaxine

Levodopa

Sumatriptan

Buspirone

Phenelzine

Procarbazine

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Take S-Adenosyl Methionine with or without food. Do not take in larger or smaller amounts than prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this supplement without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

May cause sleepiness

How it works
S-Adenosyl Methionine works by donating a one-carbon methyl group for metabolic reactions and biosynthesis of various chemicals in the body including DNA, RNA, proteins, phospholipids, and certain hormones. It is used conditions such as depression, osteoarthritis and liver diseases.
Legal Status

Approved

Unknown

Approved

Unknown

Classification

Category

Nutraceutical products

Schedule

N/A

Ademetionine - DrugBank [Internet]. Drugbank.ca. 2017 [cited 12 September 2017]. Available from:

https://www.drugbank.ca/drugs/DB00118

S-Adenosyl-L-Methionine (SAMe): In Depth [Internet]. NCCIH. 2017 [cited 12 September 2017]. Available from:

https://nccih.nih.gov/health/supplements/SAMe

Toxnet [Internet]. Toxnet.nlm.nih.gov. 2017 [cited 12 September 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2

drsertus [Internet]. 2017 [cited 12 September 2017]. Available from:

http://www.drsertus.com/wp-content/uploads/Ademta-EN.pdf

S-adenosylmethionine [Internet]. University of Maryland Medical Center. 2017 [cited 12 September 2017]. Available from:

http://www.umm.edu/health/medical/altmed/supplement/sadenosylmethionine

How will this medicine affect me?

Consult top doctors online and get an answer now
Chat now
Chat now

Looking for a doctor?

Book an appointment with the top doctors near you
Book now
Book now
Something doesn’t feel right?
Report an error

Information on this page was last updated on 14 Sep 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.