Risedronate

Description

Risedronate is used to treat or prevent osteoporosis in postmenopausal women. It is also used for the prevention and treatment of osteoporosis in men and women who are on corticosteroid therapy. This medicine can also be used to treat Paget's disease of bone, a condition in which the bones are weak, thin, deformed, and easily fractured. It is not recommended for use in children below 18 years of age.

Side effects

Major & minor side effects for Risedronate

  • Stomach pain
  • Skin Rash
  • Bone pain
  • Eye irritation
  • Nausea
  • Vomiting
  • Eye pain
  • Headache
  • Dizziness

Uses of Risedronate

What is it prescribed for?

  • Osteoporosis
  • Paget's disease
Read More
Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to risedronate or any other inactive ingredients present along with it.

Hypocalcemia

This medicine is not recommended for use in patients with hypocalcemia (low calcium levels in the blood) due to the increased risk of worsening of the patient's condition.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Inability to stand or sit upright for at least 30 minutes

This medicine is not recommended for use in patients who are unable to stand or sit upright for at least 30 minutes.

Use in Children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established. However, your doctor may prescribe this medicine in certain specific circumstances, if the benefits significantly outweigh the risks. In such a case, the patient should be monitored closely for any undesirable side effects.

Severe bone, joint, and/or muscle pain

This medicine may cause severe bone, joint, and/or muscle pain. Report any such symptoms to the doctor on priority. Your doctor may advise you to discontinue therapy based on your clinical condition.

Osteonecrosis of the Jaw

This medicine may rarely cause osteonecrosis of the jaw in some patients. This risk is especially higher in patients undergoing invasive dental procedures. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition

Missed Dose

If you are taking this medicine once daily and miss a dose, do not take it later in the day; skip the dose and follow the regular dosing schedule the next morning. Do not double the dose to make up for the missed one. If the once-weekly or once-monthly dose of this medicine is missed, take the dose the next morning and continue with the regular dosing schedule of one tablet once a week or once monthly. Do not take 2 doses in one day.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amikacin

Deferasirox

Etelcalcetide

Celecoxib

Bromfenac

Diclofenac

Aspirin

Disease interactions

Upper gastrointestinal disorders

This medicine should be used with caution in patients with upper gastrointestinal disorders since it may cause mucosal irritation and increase the risk of gastric ulcers and bleeding. It is advised to take this medicine along with a full glass of water and stand or sit upright for at least 30 minutes after the dose to reduce the chances of gastric irritation. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition. This medicine is not recommended for use in patients with abnormalities of the esophagus.

Renal Dysfunction

This medicine should be used with caution in patients with mild to moderate renal impairment due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients with severe renal impairment due to the increased risk of serious adverse effects.

Asthma

This medicine should be used with extreme caution in patients suffering from asthma due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
The desired effects of Risedronate will not be achieved if it is taken along with food. It is advised to take this medicine first thing in the morning and at least 30 minutes before eating or drinking anything other than plain water.
The combined use of Risedronate and products containing calcium, magnesium, aluminum, or iron may reduce the effectiveness of Risedronate. It is recommended not to take such products for at least 30 minutes after taking Risedronate. It is advised that you inform the doctor about all your medicines including herbs and supplements before beginning treatment with Risedronate to avoid such interactions.
Lab interactions

Bone imaging tests

This medicine may interfere with the effects of imaging agents used for bone imaging tests. It is advised that you inform the doctor and lab technician about all your current medicines including any herbs and supplements before undergoing bone imaging tests or any other lab tests.
Take this medicine exactly as advised by your doctor. Take this medicine with a full glass of plain water and swallow as a whole. Do not chew, crush, or suck the tablet in the mouth. It is advised to take this medicine first thing in the morning and at least 30 minutes before eating or drinking anything. After taking this medicine, do not eat or drink anything other than plain water for at least 30 minutes. After taking this medicine, you have to sit or stand in an upright position; do not lie down for at least 30 minutes. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine increases bone thickness and reduces the chances of bone breakage.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Bisphosphonates

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2018 [cited 27 September 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/020835s018lbl.pdf

[Internet]. Medicines.org.uk. 2018 [cited 27 September 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.3836.pdf

[Internet]. Medsafe.govt.nz. 2018 [cited 27 September 2018]. Available from:

http://www.medsafe.govt.nz/consumers/cmi/r/risedronatesandoz.pdf

Risedronate: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 27 September 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a601247.html

Risedronate - DrugBank [Internet]. Drugbank.ca. 2018 [cited 27 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00884

DailyMed - Actonel- risedronate sodium tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 27 September 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=563c6d6d-56df-43a7-a7aa-709c5ea3cdbe

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Information on this page was last updated on 16 Jan 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.