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Rifa I-6 Forte Tablet
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Rifa I-6 Forte Tablet

Manufactured byCONCEPT PHARMACEUTICALS LTD
ContainsRifampicin (600 mg) + Isoniazid (300 mg) + Pyridoxine (10 mg)
Description
Rifa I-6 Forte Tablet is a combination medicine which may be used for the treatment of tuberculosis. It is important to continue treatment with this medicine even if you feel better; do not stop the use of this medicine without consulting your doctor.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Rifa I-6 Forte Tablet

  • Clumsiness
  • Unsteady walk
  • Sleepiness
  • Dark urine
  • Loss of appetite
  • Tingling or numbness of the hands and feet
  • Joint pain
  • Skin rash
  • Unusual bleeding or bruising
  • Abdominal pain
  • Headache
  • Yellow colored eyes or skin
  • Nausea or Vomiting
  • Unusual behavior
  • Muscle pain
  • Weakness

Uses of Rifa I-6 Forte Tablet

What is it prescribed for?

  • Tuberculosis
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 2-4 hours of administration of the dose.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended while receiving this medicine due to the increased risk of adverse effects such as unusual bleeding or bruising, joint pain or swelling, fever, chills, skin rash, severe abdominal pain, yellowing of the skin or eyes, etc.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to isoniazid, rifampicin, pyridoxine or any other inactive ingredients present in the formulation.

Antiviral medications

This medicine is not recommended for use in patients receiving antiviral therapy since it may reduce the effects of antiviral medications and may lead to the development of viral resistance.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Liver Disease

This medicine should be used with extreme caution in patients with a known history of liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Liver enzymes

Use of this medicine may elevate liver enzyme levels in some patients. Close monitoring of liver enzyme levels, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Drug-resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug-resistant.

Driving or Operating machinery

Use of this medicine may cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Diabetes

This medicine should be used with caution in patients with a history of diabetes since it may alter blood glucose levels. Close monitoring of blood glucose levels, appropriate patient education, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Skin Reactions

Use of this medicine may cause severe skin reactions including Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in some patients. Report any skin rashes or mucosal lesions to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while receiving this medicine due to the increased risk of adverse effects such as unusual bleeding or bruising, joint pain or swelling, fever, chills, skin rash, severe abdominal pain, yellowing of the skin or eyes, etc.
Interaction with Medicine

Propranolol

Pimozide

Leflunomide

Levodopa

Halothane

Teriflunomide

Phenytoin

Citalopram

Clopidogrel

Warfarin

Altretamine

Phenobarbital

Disease interactions

Liver Disease

This medicine is not recommended for use in patients with acute liver disease or a known history of liver injury due to the use of this medicine. It should be used with caution in patients with a history of liver diseases due to the increased risk of serious liver injuries which may be fatal. Close monitoring of liver function tests is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Gastrointestinal Diseases

This medicine should be used with caution in patients with a history of gastrointestinal diseases, particularly colitis due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
This medicine should be taken on an empty stomach, at least 1-2 hours before or after a meal since food decreases the absorption of this medicine.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine on an empty stomach, either 30 minutes before or 2 hours after a meal. The absorption of this medicine may be reduced if it is taken along with food. Do not consume in larger or smaller amounts than advised. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

May cause sleepiness

How it works
Rifampicin and Isoniazid work by interfering with certain processes that help the bacteria to grow and increase in number; this ultimately leads to the death of the bacteria. Pyridoxine is essential for maintaining various important functions in the body including but not limited to glucose and amino acid metabolism, production of RBCs, proper functioning of the nervous system, etc. Lack of pyridoxine may result in impairment of the immune function, nervous system disorders, fatigue, numbness, etc.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Antituberculosis combinations

Schedule

Schedule H1

Rifampicin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 20 August 2018]. Available from:

https://www.drugbank.ca/drugs/DB01045

Isoniazid - DrugBank [Internet]. Drugbank.ca. 2018 [cited 15 March 2018]. Available from:

https://www.drugbank.ca/drugs/DB00951

Isoniazid [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 20 August 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/3767#

[Internet]. 2017 [cited 29 May 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/21221

Pyridoxine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 16 March 2018]. Available from:

https://www.drugbank.ca/drugs/DB00165

[Internet]. 2019 [cited 11 July 2019]. Available from:

https://apps.who.int/medicinedocs/en/d/Js5511e/2.2.html

DailyMed - Rifampin and isoniazid capsule [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 28 March 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3cc36609-8e2d-4caa-a8e0-c0367e3e52df
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Information on this page was last updated on 12 Jul 2019

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