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Rexace-MR Tablet

Manufactured byAAVHANZR PHARMACEUTICALS PVT. LTD.
ContainsAceclofenac (100 mg) + Paracetamol (325 mg) + Chlorzoxazone (250 mg)
Description
Rexace-MR Tablet is a combination medicine that consists of aceclofenac, paracetamol and chlorzoxazone. It is used for the treatment of pain, swelling, and tenderness associated with muscle injury and muscle spasms. This medicine works by blocking the release of certain chemical messengers that causes pain, swelling and fever. Rexace-MR Tablet may cause side effects like nausea, vomiting, stomach pain, heartburn, loss of appetite and diarrhoea. If any of these side effects persist for a long time or worsen, consult your doctor at the earliest. This medicine may cause dizziness or sleepiness. Avoid driving or operating machines if you feel dizzy or sleepy after taking this medicine. Rexace-MR Tablet should be taken with food to avoid stomach irritation. Adhere to the dose and frequency prescribed by your doctor. You should keep taking the medicine even if you feel better until your doctor says to stop using it. Rexace-MR Tablet may interact with other medicines. Inform your doctor if you have other medical conditions such as liver, kidney or heart conditions, peptic ulcers, etc., before taking Rexace-MR Tablet. Let your doctor know all the other medicines you are using, to make sure this medicine is safe. Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding. Rexace-MR Tablet may cause excessive drowsiness and increase the risk of liver damage if you consume alcohol while on treatment with it. This medicine is most effective when taken along with proper rest and exercise.

Side effects

Major & minor side effects for Rexace-MR Tablet

  • Bloody and cloudy urine
  • Bloody stool
  • Dark urine
  • Dizziness
  • Nausea and vomiting
  • Drowsiness
  • Weakness
  • Stomach pain
  • Tightness of chest
  • Constipation
  • Diarrhoea
  • Skin rash
  • Heartburn
  • Loss of appetite

Uses of Rexace-MR Tablet

What is it prescribed for?

  • Pain due to muscle spasm
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The pain-relieving effect of Rexace-MR Tablet can be observed within one hour of intake.
  • How long do the effects of this medicine last?
    Rexace-MR Tablet remains active in the body for up to 12-16 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol with Rexace-MR Tablet may lower your blood pressure and can cause dizziness, headache, gastrointestinal bleeding, weakness, fatigue, etc.
  • Is this a habit forming medicine?
    Rexace-MR Tablet has no habit forming tendency.
  • Can this medicine be taken during pregnancy?
    Rexace-MR Tablet is not recommended in pregnancy as it may cause miscarriage or may affect foetal heart growth. Discuss the potential benefits and risks with your doctor before starting the therapy.
  • Can this medicine be taken while breast-feeding?
    Rexace-MR Tablet is known to pass into breastmilk. It is recommended to discontinue breastfeeding or taking Rexace-MR Tablet, based on your clinical condition. Discuss all the benefits and risks with your doctor before starting the therapy.

Allergy

Avoid taking Rexace-MR Tablet if you are allergic to it. However, seek immediate medical help if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc.

Kidney diseases

Rexace-MR Tablet is extensively excreted through the kidneys. The damaged kidneys cannot filter out this medicine effectively and this leads to its accumulation. This may worsen the condition of impaired kidneys. Hence, consult your doctor before taking this medicine.

Severe liver impairment

People with liver problems need special consideration while taking Rexace-MR Tablet. The use of this medicine is generally not recommended in severe liver problems because it can increase the risk of liver damage. Hence, consult your doctor before taking this medicine.

Gastrointestinal perforation

Rexace-MR Tablet is not recommended for use in perforation disorders since it may cause stomach and intestinal bleeding and ulcers.

Peptic Ulcer

Avoid taking Rexace-MR Tablet if you have peptic ulcers. It can cause severe swelling and bleed in the stomach, colon, and anus.

Coronary artery bypass surgery

A coronary artery bypass graft (CABG) is a surgical procedure used to treat coronary heart disease. It diverts blood around narrowed or blocked parts of the major blood vessels to improve blood flow and oxygen supply to the heart. Do not take Rexace-MR Tablet for relieving pain due to heart surgery.
Warnings for special population

Pregnancy

Rexace-MR Tablet is not recommended in pregnancy as it may cause miscarriage or may affect foetal heart growth. Discuss the potential benefits and risks with your doctor before starting the therapy.

Breast-feeding

Rexace-MR Tablet is known to pass into breastmilk. It is recommended to discontinue breastfeeding or taking Rexace-MR Tablet, based on your clinical condition. Discuss all the benefits and risks with your doctor before starting the therapy.
General warnings

Chronic Malnutrition

Malnutrition and fasting can increase the risk of Rexace-MR Tablet overdose. Your doctor will adjust the dose depending on your body weight.

Gastro-intestinal toxicity

Long term use of Rexace-MR Tablet can cause damage to the stomach and intestine.

Heart surgery

Rexace-MR Tablet is not recommended for use in peoplewho have undergone recent heart surgery as it may worsen their condition.

Driving or operating machines

Rexace-MR Tablet may cause sleepiness or dizziness. Avoid driving vehicles and operating heavy machines after taking this medicine.

Missed Dose

If you forget to take a dose of Rexace-MR Tablet at the scheduled time, take it as soon as you remember. However, if it is time for your next dose, skip the missed dose. Do not double the dose to make up for the missed one.

Overdose

Never take more than the prescribed dose. If you suspect that you might have taken an overdose of Rexace-MR Tablet, go to the emergency department of your local hospital.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol with Rexace-MR Tablet may lower your blood pressure and can cause dizziness, headache, gastrointestinal bleeding, weakness, fatigue, etc.
Interaction with Medicine

Carbamazepine

Lithium

Phenytoin

Tramadol

Sodium Nitrite

Leflunomide

Prilocaine

Digoxin

Corticosteroids

Antihypertensives

Disease interactions

Liver disease

Do not take Rexace-MR Tablet if you have liver problems as it may cause liver damage.

NSAID-induced asthma

NSAID-induced asthma is an allergic condition of the respiratory system caused by the use of NSAIDs (Non-steroidal Anti-inflammatory Drugs- medicines that are widely used to relieve pain and reduce swelling). In this, there is a narrowing of the airways of your lungs leading to severe breathing difficulty. Rexace-MR Tablet is not recommended for use in this condition.

Kidney diseases

If you take Rexace-MR Tablet in high doses for a prolonged period of time, it may cause kidney problems, such as painful urination and protein or blood in the urine. Hence, close monitoring of kidney function is necessary.
Food interactions
Information not available.
Lab interactions

5-HIAA Urine Test

5-HIAA urine test measures the amount of serotonin (a key hormone that stabilizes our mood, feelings of well-being, and happiness) in the body. Rexace-MR Tablet can interfere with a urine test and may give a false-positive result. Inform your doctor and lab technician about all your current medicines before undergoing any lab test.
Take Rexace-MR Tablet with food to avoid stomach irritation. Drink adequate water for easy swallowing. Never take more than the prescribed dose. Avoid consuming alcohol when taking Rexace-MR Tablet as it may cause excessive drowsiness and increase the risk of liver damage. Older adults may have increased drowsiness, confusion, and a higher risk of falling as a result of taking Rexace-MR Tablet. Do not take Rexace-MR Tablet with any other medicine containing acetaminophen (drugs for pain/fever or cough-and-cold) without asking your doctor first. Take Rexace-MR Tablet at around the same time daily. Do not stop the use of this medicine without consulting your doctor. Do not break, crush or chew the tablet in the mouth. Take it immediately after peeling it from the strip. Keep the medicine out of reach of children and pets. Do not use Rexace-MR Tablet after the expiry date. Ensure that the unused or expired medicine is disposed of properly.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Rexace-MR Tablet is a combination of aceclofenac, paracetamol and chlorzoxazone. Aceclofenac and Paracetamol work by blocking the release of certain chemical substances in your brain that cause pain and swelling and fever. Chlorzoxazone is a muscle relaxant. It works on the centres of the brain and spinal cord to relieve muscle stiffness or spasm, thereby improving muscle movement.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Anti-inflammatory agents, Skeletal muscle relaxants, Miscellaneous analgesics

Schedule

Schedule H

Pubchem.ncbi.nlm.nih.gov. 2021. Aceclofenac. [online] Available at: < [Accessed 7 May 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Aceclofenac>

Pubchem.ncbi.nlm.nih.gov. 2020. Acetaminophen. [online] Available at: < [Accessed 7 May 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Acetaminophen>

Pubchem.ncbi.nlm.nih.gov. 2021. Chlorzoxazone. [online] Available at: < [Accessed 26 May 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Chlorzoxazone>

Dailymed.nlm.nih.gov. 2021. DailyMed - CHLORZOXAZONE tablet. [online] Available at: < [Accessed 14 July 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2f05e8e2-616f-475b-ac9f-c42e1a5dbe81>

Medicines.org.uk. 2021. Aceclofenac 100 mg film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 6 August 2021].

https://www.medicines.org.uk/emc/product/4240/smpc>
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Information on this page was last updated on 6 Oct 2021

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